<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2026-084</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-10017</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РЕПРОДУКТИВНОЕ ЗДОРОВЬЕ И ВРТ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REPRODUCTIVE HEALTH AND ART</subject></subj-group></article-categories><title-group><article-title>Актуальный подход к лечению воспалительных заболеваний органов малого таза у женщин в амбулаторных условиях</article-title><trans-title-group xml:lang="en"><trans-title>An up-to-date approach to the treatment of pelvic inflammatory diseases in women on an outpatient basis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1462-4987</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тихомиров</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Tikhomirov</surname><given-names>A. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тихомиров Александр Леонидович, д.м.н., профессор, профессор кафедры акушерства, гинекологии и репродуктивной медицины лечебного факультета</p><p>127006, Россия, Москва, ул. Долгоруковская, д. 4</p></bio><bio xml:lang="en"><p>Aleksander L. Tikhomirov, Dr. Sci. (Med.), Professor, Professor of the Department of Obstetrics, Gynecology  and Reproductive Medicine, Faculty of Medicine</p><p>4, Dolgorukovskaya St., Moscow, 127006, Russia</p></bio><email xlink:type="simple">tikhomiroval@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1599-0399</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Казенашев</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kazenashev</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Казенашев Виктор Викторович, к.м.н., ассистент кафедры акушерства, гинекологии и репродуктивной медицины лечебного факультета</p><p>127006, Россия, Москва, ул. Долгоруковская, д. 4</p></bio><bio xml:lang="en"><p>Victor V. Kazenashev, Cand. Sci. (Med.), Assistant Professor of the Department of Obstetrics, Gynecology  and Reproductive Medicine, Faculty of Medicine</p><p>4, Dolgorukovskaya St., Moscow, 127006, Russia</p></bio><email xlink:type="simple">vkazenashev@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-6707-4164</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маминова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Maminova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маминова Мария Владимировна, врач-ординатор по специальности акушерство и гинекология</p><p>127006, Россия, Москва, ул. Долгоруковская, д. 4</p></bio><bio xml:lang="en"><p>Maria V. Maminova, Resident Physician in Obstetrics and Gynecology</p><p>4, Dolgorukovskaya St., Moscow, 127006, Russia</p></bio><email xlink:type="simple">mv_maminova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-2318-1377</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гараева</surname><given-names>Л. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Garaeva</surname><given-names>L. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гараева Лилия Рашитовна, к.м.н., врач – акушер-гинеколог, заведующая отделением гинекологии, </p><p>140181, Россия, Московская обл., Жуковский, ул. Фрунзе, д. 1 </p></bio><bio xml:lang="en"><p>Liliya R. Garaeva,Cand. Sci. (Med.), Obstetrician-Gynecologist, Head of the Gynecology Department</p><p>1, Frunze St., Zhukovsky, Moscow Region, 140180, Russia </p></bio><email xlink:type="simple">garaevlil@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет медицины (РосУниМед)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian University of Medicine (ROSUNIMED)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Жуковская областная клиническая больница</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Zhukovsky Regional Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>11</day><month>05</month><year>2026</year></pub-date><volume>0</volume><issue>4</issue><fpage>25</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Тихомиров А.Л., Казенашев В.В., Маминова М.В., Гараева Л.Р., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Тихомиров А.Л., Казенашев В.В., Маминова М.В., Гараева Л.Р.</copyright-holder><copyright-holder xml:lang="en">Tikhomirov A.L., Kazenashev V.V., Maminova M.V., Garaeva L.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/10017">https://www.med-sovet.pro/jour/article/view/10017</self-uri><abstract><p>В настоящий момент воспалительные заболевания верхних отделов репродуктивного тракта являются одной из самых распространенных гинекологических проблем в мире: ежегодно регистрируется около 448 млн новых случаев воспалительных заболеваний органов малого таза (ВЗОМТ), что составляет до 60% от общего числа гинекологических заболеваний. Пик заболеваемости (4–12%) приходится на возраст 17–28 лет, что связано с сексуальной активностью и низкой частотой использования барьерных методов контрацепции. ВЗОМТ представляют собой серьезную проблему здравоохранения, оказывающую значительное влияние на здоровье женщин репродуктивного возраста. Эта группа заболеваний занимает лидирующее положение в структуре гинекологической заболеваемости и является наиболее частой причиной госпитализации женщин. Целью статьи явилось всестороннее рассмотрение проблемы ВЗОМТ у женщин репродуктивного возраста с позиции междисциплинарного подхода. В статье приведен клинический случай лечения пациентки с диагнозом: ВЗОМТ, двусторонний сальпингоофорит. Пациентка ранее получала антибактериальную терапию в стационаре, куда обратилась в связи с острыми симптомами (тянущие боли внизу живота, желтые выделения из половых органов). Симптомы появились у нее после незащищенного полового акта. В связи с тем, что при лечении в стационаре у пациентки не учли такие возможные этиологические факторы развития ВЗОМТ, как инфицирование хламидиями и микоплазмами, при повторном обращении до получения результатов ПЦР-исследований была назначена эмпирическая терапия: доксициклина моногидрат 100 мг 2 раза в сутки в течение 14 дней. К концу 2-го дня назначенного лечения пациентка отметила улучшение состояния: дискомфорт и тянущие боли внизу живота не беспокоят. Менструация в срок, безболезненная, выделения умеренные. Эффективность лечения оценена через 21 день после завершения 14-дневного курса терапии с использованием препарата Доксициклин ЭКСПРЕСС: отмечено клиническое и микробиологическое излечение.</p></abstract><trans-abstract xml:lang="en"><p>Currently, pelvic inflammatory diseases (PID) are one of the most common gynecological problems in the world, with more than 448 million new cases reported annually (up to 60% of the total number of gynecological diseases). The peak of the disease (4–12%) occurs at the age of 17–28, which is associated with sexual activity and a low frequency of using barrier methods of contraception. PID represent a serious health problem that has a significant impact on the health of women of reproductive age. This group of diseases occupies a leading position in the structure of gynecological morbidity and is the most common cause of hospitalization in women. The aim of this article is to provide a comprehensive review of the issue of PID in women of reproductive age from an interdisciplinary perspective. This article presents a clinical case of a patient diagnosed with PID and bilateral salpingoophoritis. The patient had previously received antibiotic therapy in the hospital, where she sought medical help due to acute symptoms (pulling pain in the lower abdomen, yellow vaginal discharge). The symptoms appeared after unprotected sex. As during hospital treatment, potential etiological factors contributing to the onset of PID in the patient such as exposure to chlamydia and mycoplasma were not taken into account, empirical therapy with doxycycline monohydrate (100 mg twice daily for 14 days) was prescribed at patient’s follow-up visit before the results from the PCR test were available. By the end of the second day of prescribed therapy, the patient noted that her well-being was improved: discomfort and pulling pain in the lower abdomen disappeared. Periods were regular, pain-free, with moderate menstrual flow. The treatment efficacy was evaluated 21 days after completion of a 14-day course of Doxycycline EXPRESS, which showed that the patient achieved clinical and microbiological cure.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инфекции</kwd><kwd>передающиеся половым путем</kwd><kwd>хроническая тазовая боль</kwd><kwd>бесплодие</kwd><kwd>эктопическая беременность</kwd><kwd>доксициклин</kwd><kwd>Доксициклин ЭКСПРЕСС</kwd><kwd>диспергируемые антибиотики</kwd></kwd-group><kwd-group xml:lang="en"><kwd>sexual transmitted disease</kwd><kwd>chronic pelvic pain</kwd><kwd>infertility</kwd><kwd>ectopic pregnancy</kwd><kwd>endometriosis</kwd><kwd>doxycycline</kwd><kwd>Doxycycline EXPRESS</kwd><kwd>dispersible antibiotics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Frock-Welnak DN, Tam J. Identification and Treatment of Acute Pelvic Inflammatory Disease and Associated Sequelae. Obstet Gynecol Clin North Am. 2022;49(3):551–579. https://doi.org/10.1016/j.ogc.2022.02.019.</mixed-citation><mixed-citation xml:lang="en">Frock-Welnak DN, Tam J. Identification and Treatment of Acute Pelvic Inflammatory Disease and Associated Sequelae. Obstet Gynecol Clin North Am. 2022;49(3):551–579. https://doi.org/10.1016/j.ogc.2022.02.019.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Marcinkowski KA, Mehta V, Mercier R, Berghella V. Pelvic inflammatory disease in pregnancy: a systematic review focusing on perinatal outcomes. Am J Obstet Gynecol MFM. 2022;4(4):100643. https://doi.org/10.1016/j.ajogmf.2022.100643.</mixed-citation><mixed-citation xml:lang="en">Marcinkowski KA, Mehta V, Mercier R, Berghella V. Pelvic inflammatory disease in pregnancy: a systematic review focusing on perinatal outcomes. Am J Obstet Gynecol MFM. 2022;4(4):100643. https://doi.org/10.1016/j.ajogmf.2022.100643.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Workowski KA, Bolan GA. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR-3):1–137. Available at: https://www.cdc.gov/mmwr/preview/mmwrhtml/rr6403a1.htm.</mixed-citation><mixed-citation xml:lang="en">Workowski KA, Bolan GA. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR-3):1–137. Available at: https://www.cdc.gov/mmwr/preview/mmwrhtml/rr6403a1.htm.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Shroff S. Infectious Vaginitis, Cervicitis, and Pelvic Inflammatory Disease. Med Clin North Am. 2023;107(2):299–315. https://doi.org/10.1016/j.mcna.2022.10.009.</mixed-citation><mixed-citation xml:lang="en">Shroff S. Infectious Vaginitis, Cervicitis, and Pelvic Inflammatory Disease. Med Clin North Am. 2023;107(2):299–315. https://doi.org/10.1016/j.mcna.2022.10.009.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ross J, Guaschino S, Cusini M, Jensen J. 2017 European guideline for the management of pelvic inflammatory disease. Int J STD AIDS. 2018;29(2):108–114. https://doi.org/10.1177/0956462417744099.</mixed-citation><mixed-citation xml:lang="en">Ross J, Guaschino S, Cusini M, Jensen J. 2017 European guideline for the management of pelvic inflammatory disease. Int J STD AIDS. 2018;29(2):108–114. https://doi.org/10.1177/0956462417744099.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Савельева ГМ, Сухих ГТ, Серов ВН, Радзинский ВЕ, Манухин ИБ (ред.). Гинекология: национальное руководство. 2-е изд., перераб. и доп. М.: ГЭОТАР-Медиа; 2017. 1008 с. Режим доступа: https://www.rosmedlib.ru/book/ISBN9785970441527.html.</mixed-citation><mixed-citation xml:lang="en">Савельева ГМ, Сухих ГТ, Серов ВН, Радзинский ВЕ, Манухин ИБ (ред.). Гинекология: национальное руководство. 2-е изд., перераб. и доп. М.: ГЭОТАР-Медиа; 2017. 1008 с. Режим доступа: https://www.rosmedlib.ru/book/ISBN9785970441527.html.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Munro K, Gharaibeh A, Nagabushanam S, Martin C. Diagnosis and management of tubo-ovarian abscesses. Obstet Gynaecol. 2018;20(1):11–19. https://doi.org/10.1111/tog.12447.</mixed-citation><mixed-citation xml:lang="en">Munro K, Gharaibeh A, Nagabushanam S, Martin C. Diagnosis and management of tubo-ovarian abscesses. Obstet Gynaecol. 2018;20(1):11–19. https://doi.org/10.1111/tog.12447.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Hillier SL, Bernstein KT, Aral S. A Review of the Challenges and Complexities in the Diagnosis, Etiology, Epidemiology, and Pathogenesis of Pelvic Inflammatory Disease. J Infect Dis. 2021;224(12 Suppl. 2):S23–S28. https://doi.org/10.1093/infdis/jiab116.</mixed-citation><mixed-citation xml:lang="en">Hillier SL, Bernstein KT, Aral S. A Review of the Challenges and Complexities in the Diagnosis, Etiology, Epidemiology, and Pathogenesis of Pelvic Inflammatory Disease. J Infect Dis. 2021;224(12 Suppl. 2):S23–S28. https://doi.org/10.1093/infdis/jiab116.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ravel J, Moreno I, Simón C. Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease. Am J Obstet Gynecol. 2021;224(3):251–257. https://doi.org/10.1016/j.ajog.2020.10.019.</mixed-citation><mixed-citation xml:lang="en">Ravel J, Moreno I, Simón C. Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease. Am J Obstet Gynecol. 2021;224(3):251–257. https://doi.org/10.1016/j.ajog.2020.10.019.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Хоффман БЛ, Шордж ДжО, Хальворсон ЛМ, Хамид ША, Кортон ММ, Шаффер ДжИ (ред.). Гинекология по Уильямсу. М.: ГЭОТАР-Медиа; 2023. 1280 с.</mixed-citation><mixed-citation xml:lang="en">Хоффман БЛ, Шордж ДжО, Хальворсон ЛМ, Хамид ША, Кортон ММ, Шаффер ДжИ (ред.). Гинекология по Уильямсу. М.: ГЭОТАР-Медиа; 2023. 1280 с.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Simms I, Eastick K, Mallinson H, Thomas K, Gokhale R, Hay P et al. Associations between Mycoplasma genitalium, Chlamydia trachomatis and pelvic inflammatory disease. J Clin Pathol. 2003;56(8):616–618. https://doi.org/10.1136/jcp.56.8.616.</mixed-citation><mixed-citation xml:lang="en">Simms I, Eastick K, Mallinson H, Thomas K, Gokhale R, Hay P et al. Associations between Mycoplasma genitalium, Chlamydia trachomatis and pelvic inflammatory disease. J Clin Pathol. 2003;56(8):616–618. https://doi.org/10.1136/jcp.56.8.616.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Brunham RC, Gottlieb SL, Paavonen J. Pelvic inflammatory disease. N Engl J Med. 2015;372(21):2039–2048. https://doi.org/10.1056/NEJMra1411426.</mixed-citation><mixed-citation xml:lang="en">Brunham RC, Gottlieb SL, Paavonen J. Pelvic inflammatory disease. N Engl J Med. 2015;372(21):2039–2048. https://doi.org/10.1056/NEJMra1411426.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Curry A, Williams T, Penny ML. Pelvic Inflammatory Disease: Diagnosis, Management, and Prevention. Am Fam Physician. 2019;100(6):357–364. Available at: https://www.aafp.org/pubs/afp/issues/2019/0915/p357.html.</mixed-citation><mixed-citation xml:lang="en">Curry A, Williams T, Penny ML. Pelvic Inflammatory Disease: Diagnosis, Management, and Prevention. Am Fam Physician. 2019;100(6):357–364. Available at: https://www.aafp.org/pubs/afp/issues/2019/0915/p357.html.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Hunt S, Vollenhoven B. Pelvic inflammatory disease and infertility. Aust J Gen Pract. 2023;52(4):215–218. https://doi.org/10.31128/AJGP-09-22-6576.</mixed-citation><mixed-citation xml:lang="en">Hunt S, Vollenhoven B. Pelvic inflammatory disease and infertility. Aust J Gen Pract. 2023;52(4):215–218. https://doi.org/10.31128/AJGP-09-22-6576.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Darville T. Pelvic Inflammatory Disease Due to Neisseria gonorrhoeae and Chlamydia trachomatis: Immune Evasion Mechanisms and Pathogenic Disease Pathways. J Infect Dis. 2021;224(Suppl. 2):S39–S46. https://doi.org/10.1093/infdis/jiab031.</mixed-citation><mixed-citation xml:lang="en">Darville T. Pelvic Inflammatory Disease Due to Neisseria gonorrhoeae and Chlamydia trachomatis: Immune Evasion Mechanisms and Pathogenic Disease Pathways. J Infect Dis. 2021;224(Suppl. 2):S39–S46. https://doi.org/10.1093/infdis/jiab031.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Zheng X, O’Connell CM, Zhong W, Nagarajan UM, Tripathy M, Lee D et al. Discovery of Blood Transcriptional Endotypes in Women with Pelvic Inflammatory Disease. J Immunol. 2018;200(8):2941–2956. https://doi.org/10.4049/jimmunol.1701658.</mixed-citation><mixed-citation xml:lang="en">Zheng X, O’Connell CM, Zhong W, Nagarajan UM, Tripathy M, Lee D et al. Discovery of Blood Transcriptional Endotypes in Women with Pelvic Inflammatory Disease. J Immunol. 2018;200(8):2941–2956. https://doi.org/10.4049/jimmunol.1701658.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Handing JW, Ragland SA, Bharathan UV, Criss AK. The MtrCDE Efflux Pump Contributes to Survival of Neisseria gonorrhoeae From Human Neutrophils and Their Antimicrobial Components. Front Microbiol. 2018;9:2688. https://doi.org/10.3389/fmicb.2018.02688.</mixed-citation><mixed-citation xml:lang="en">Handing JW, Ragland SA, Bharathan UV, Criss AK. The MtrCDE Efflux Pump Contributes to Survival of Neisseria gonorrhoeae From Human Neutrophils and Their Antimicrobial Components. Front Microbiol. 2018;9:2688. https://doi.org/10.3389/fmicb.2018.02688.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson MB, Criss AK. Neisseria gonorrhoeae phagosomes delay fusion with primary granules to enhance bacterial survival inside human neutrophils. Cell Microbiol. 2013;15(8):1323–1340. https://doi.org/10.1111/cmi.12117.</mixed-citation><mixed-citation xml:lang="en">Johnson MB, Criss AK. Neisseria gonorrhoeae phagosomes delay fusion with primary granules to enhance bacterial survival inside human neutrophils. Cell Microbiol. 2013;15(8):1323–1340. https://doi.org/10.1111/cmi.12117.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Kobayashi H. Similarities in Pathogenetic Mechanisms Underlying the Bidirectional Relationship between Endometriosis and Pelvic Inflammatory Disease. Diagnostics. 2023;13(5):868. https://doi.org/10.3390/diagnostics13050868.</mixed-citation><mixed-citation xml:lang="en">Kobayashi H. Similarities in Pathogenetic Mechanisms Underlying the Bidirectional Relationship between Endometriosis and Pelvic Inflammatory Disease. Diagnostics. 2023;13(5):868. https://doi.org/10.3390/diagnostics13050868.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Koninckx PR, Ussia A, Tahlak M, Adamyan L, Wattiez A, Martin DC, Gomel V. Infection as a potential cofactor in the genetic-epigenetic pathophysiology of endometriosis: a systematic review. Facts Views Vis Obgyn. 2019;11(3):209–216. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC7020943/.</mixed-citation><mixed-citation xml:lang="en">Koninckx PR, Ussia A, Tahlak M, Adamyan L, Wattiez A, Martin DC, Gomel V. Infection as a potential cofactor in the genetic-epigenetic pathophysiology of endometriosis: a systematic review. Facts Views Vis Obgyn. 2019;11(3):209–216. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC7020943/.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Liu W, Zhang Z, Li D. Primary ovarian abscess in virginal young woman with huge endometriosis cyst: A case report. Medicine. 2022;101(21):e29463. https://doi.org/10.1097/MD.0000000000029463.</mixed-citation><mixed-citation xml:lang="en">Liu W, Zhang Z, Li D. Primary ovarian abscess in virginal young woman with huge endometriosis cyst: A case report. Medicine. 2022;101(21):e29463. https://doi.org/10.1097/MD.0000000000029463.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Veale R, Hughes C, Woolley I. A novel case of bilateral tubo-ovarian abscesses attributed to Ruminococcus gnavus without gastrointestinal involvement. Anaerobe. 2021;67:102312. https://doi.org/10.1016/j.anaerobe.2020.102312.</mixed-citation><mixed-citation xml:lang="en">Veale R, Hughes C, Woolley I. A novel case of bilateral tubo-ovarian abscesses attributed to Ruminococcus gnavus without gastrointestinal involvement. Anaerobe. 2021;67:102312. https://doi.org/10.1016/j.anaerobe.2020.102312.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Tai FW, Chang CY, Chiang JH, Lin WC, Wan L. Association of Pelvic Inflammatory Disease with Risk of Endometriosis: A Nationwide Cohort Study Involving 141,460 Individuals. J Clin Med. 2018;7(11):379. https://doi.org/10.3390/jcm7110379.</mixed-citation><mixed-citation xml:lang="en">Tai FW, Chang CY, Chiang JH, Lin WC, Wan L. Association of Pelvic Inflammatory Disease with Risk of Endometriosis: A Nationwide Cohort Study Involving 141,460 Individuals. J Clin Med. 2018;7(11):379. https://doi.org/10.3390/jcm7110379.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Zografou Themeli M, Nirgianakis K, Neumann S, Imboden S, Mueller MD. Endometriosis is a risk factor for recurrent pelvic inflammatory disease after tubo-ovarian abscess surgery. Arch Gynecol Obstet. 2023;307(1):139–148. https://doi.org/10.1007/s00404-022-06743-6.</mixed-citation><mixed-citation xml:lang="en">Zografou Themeli M, Nirgianakis K, Neumann S, Imboden S, Mueller MD. Endometriosis is a risk factor for recurrent pelvic inflammatory disease after tubo-ovarian abscess surgery. Arch Gynecol Obstet. 2023;307(1):139–148. https://doi.org/10.1007/s00404-022-06743-6.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Clarizia R, Capezzuoli T, Ceccarello M, Zorzi C, Stepniewska A, Roviglione G et al. Inflammation calls for more: Severe pelvic inflammatory disease with or without endometriosis. Outcomes on 311 laparoscopically treated women. J Gynecol Obstet Hum Reprod. 2021;50(3):101811. https://doi.org/10.1016/j.jogoh.2020.101811.</mixed-citation><mixed-citation xml:lang="en">Clarizia R, Capezzuoli T, Ceccarello M, Zorzi C, Stepniewska A, Roviglione G et al. Inflammation calls for more: Severe pelvic inflammatory disease with or without endometriosis. Outcomes on 311 laparoscopically treated women. J Gynecol Obstet Hum Reprod. 2021;50(3):101811. https://doi.org/10.1016/j.jogoh.2020.101811.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Maksym RB, Hoffmann-Młodzianowska M, Skibińska M, Rabijewski M, Mackiewicz A, Kieda C. Immunology and Immunotherapy of Endometriosis. J Clin Med. 2021;10(24):5879. https://doi.org/10.3390/jcm10245879.</mixed-citation><mixed-citation xml:lang="en">Maksym RB, Hoffmann-Młodzianowska M, Skibińska M, Rabijewski M, Mackiewicz A, Kieda C. Immunology and Immunotherapy of Endometriosis. J Clin Med. 2021;10(24):5879. https://doi.org/10.3390/jcm10245879.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Tang F, Deng M, Xu C, Yang R, Ji X, Hao M et al. Unraveling the microbial puzzle: exploring the intricate role of gut microbiota in endometriosis pathogenesis. Front Cell Infect Microbiol. 2024;14:1328419. https://doi.org/10.3389/fcimb.2024.1328419.</mixed-citation><mixed-citation xml:lang="en">Tang F, Deng M, Xu C, Yang R, Ji X, Hao M et al. Unraveling the microbial puzzle: exploring the intricate role of gut microbiota in endometriosis pathogenesis. Front Cell Infect Microbiol. 2024;14:1328419. https://doi.org/10.3389/fcimb.2024.1328419.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Jiang I, Yong PJ, Allaire C, Bedaiwy MA. Intricate Connections between the Microbiota and Endometriosis. Int J Mol Sci. 2021;22(11):5644. https://doi.org/10.3390/ijms22115644.</mixed-citation><mixed-citation xml:lang="en">Jiang I, Yong PJ, Allaire C, Bedaiwy MA. Intricate Connections between the Microbiota and Endometriosis. Int J Mol Sci. 2021;22(11):5644. https://doi.org/10.3390/ijms22115644.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Li H, Zhao Y, Chang XH, Wang Y, Zhu HL. Clinical characteristics, treatment status and complications in women with tube ovarian abscess and endometriosis: a retrospective study. BMC Womens Health. 2021;21(1):109. https://doi.org/10.1186/s12905-020-01119-x.</mixed-citation><mixed-citation xml:lang="en">Li H, Zhao Y, Chang XH, Wang Y, Zhu HL. Clinical characteristics, treatment status and complications in women with tube ovarian abscess and endometriosis: a retrospective study. BMC Womens Health. 2021;21(1):109. https://doi.org/10.1186/s12905-020-01119-x.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Syed Khaja AS, Saleem M, Zafar M, Moursi S, Mohammed GEY, Shahid SMA et al. Association between pelvic inflammatory disease and risk of ovarian, uterine, cervical, and vaginal cancers-a meta-analysis. Arch Gynecol Obstet. 2024;310(5):2577–2585. https://doi.org/10.1007/s00404-024-07748-z.</mixed-citation><mixed-citation xml:lang="en">Syed Khaja AS, Saleem M, Zafar M, Moursi S, Mohammed GEY, Shahid SMA et al. Association between pelvic inflammatory disease and risk of ovarian, uterine, cervical, and vaginal cancers-a meta-analysis. Arch Gynecol Obstet. 2024;310(5):2577–2585. https://doi.org/10.1007/s00404-024-07748-z.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Jonsson S, Jonsson H, Lundin E, Häggström C, Idahl A. Pelvic inflammatory disease and risk of borderline ovarian tumors: A national population-based case-control study in Sweden. Int J Cancer. 2025;156(3):529–537. https://doi.org/10.1002/ijc.35180.</mixed-citation><mixed-citation xml:lang="en">Jonsson S, Jonsson H, Lundin E, Häggström C, Idahl A. Pelvic inflammatory disease and risk of borderline ovarian tumors: A national population-based case-control study in Sweden. Int J Cancer. 2025;156(3):529–537. https://doi.org/10.1002/ijc.35180.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Адамян ЛВ, Андреева ЕН. Редкие формы эндометриоза. Проблемы репродукции. 2022;(1):45–53. https://doi.org/10.17116/repro20222801145.</mixed-citation><mixed-citation xml:lang="en">Adamyan LV, Andreeva EN. The rarest forms of endometriosis. Russian Journal of Human Reproduction. 2022;(1):45–53. (In Russ.) https://doi.org/10.17116/repro20222801145.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Адамян ЛВ, Протасова АЭ, Асатурова АВ, Раскин ГА. Эндометриоз-ассоциированные заболевания, эндометриоз и рак: что общего? Проблемы репродукции. 2022;28(1):65–74. https://doi.org/10.17116/repro20222801165.</mixed-citation><mixed-citation xml:lang="en">Adamyan LV, Protasova AE, Asaturova AV, Raskin GA. Endometriosis associated diseases, endometriosis and cancer: what is in common? Russian Journal of Human Reproduction. 2022;28(1):65–74. (In Russ.) https://doi.org/10.17116/repro20222801165.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Chang CY, Lin KY, Huang CC, Lin WC. Association of pelvic inflammatory disease (PID) with ovarian cancer: a nationwide population-based retrospective cohort study from Taiwan. BMC Womens Health. 2021;21(1):274. https://doi.org/10.1186/s12905-021-01413-2.</mixed-citation><mixed-citation xml:lang="en">Chang CY, Lin KY, Huang CC, Lin WC. Association of pelvic inflammatory disease (PID) with ovarian cancer: a nationwide population-based retrospective cohort study from Taiwan. BMC Womens Health. 2021;21(1):274. https://doi.org/10.1186/s12905-021-01413-2.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Workowski KA, Bachmann LH, Chan PA, Johnston CM, Muzny CA, Park I et al. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recomm Rep. 2021;70(4):1–187. https://doi.org/10.15585/mmwr.rr7004a1.</mixed-citation><mixed-citation xml:lang="en">Workowski KA, Bachmann LH, Chan PA, Johnston CM, Muzny CA, Park I et al. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recomm Rep. 2021;70(4):1–187. https://doi.org/10.15585/mmwr.rr7004a1.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Brun JL, Castan B, de Barbeyrac B, Cazanave C, Charvériat A, Faure K et al. Pelvic inflammatory diseases: Updated French guidelines. J Gynecol Obstet Hum Reprod. 2020;49(5):101714. https://doi.org/10.1016/j.jogoh.2020.101714.</mixed-citation><mixed-citation xml:lang="en">Brun JL, Castan B, de Barbeyrac B, Cazanave C, Charvériat A, Faure K et al. Pelvic inflammatory diseases: Updated French guidelines. J Gynecol Obstet Hum Reprod. 2020;49(5):101714. https://doi.org/10.1016/j.jogoh.2020.101714.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Адамян ЛВ, Андреева ЕН, Артымук НВ, Белокриницкая ТЕ, Беженарь ВФ, Сутурина ЛВ и др. Воспалительные болезни женских тазовых органов. Клинические рекомендации. Акушерство и гинекология. 2025;(S7):4. https://doi.org/10.18565/aig.2025.182.</mixed-citation><mixed-citation xml:lang="en">Adamyan LV, Andreeva EN, Artymuk NV, Belokrinitskaya TE, Bezhenar VF, Suturina LV et al. Inflammatory Diseases of the Female Pelvic Organs. Clinical Guidelines. Akusherstvo i Ginekologiya (Russian Federation). 2025;(S7):4. (In Russ.) https://doi.org/10.18565/aig.2025.182.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Зырянов СК, Байбулатова ЕА. Использование новых лекарственных форм антибиотиков как путь повышения эффективности и безопасности антибактериальной терапии. Антибиотики и химиотерапия. 2019;64(3-4):81–91. Режим доступа: https://www.antibiotics-chemotherapy.ru/jour/article/view/132.</mixed-citation><mixed-citation xml:lang="en">Zyryanov SK, Baibulatova EA. The Use of New Dosage Forms of Antibiotics as a Way to Improve the Effectiveness and Safety of Antibiotic Therapy. Antibiotiki i Khimioterapiya. 2019;64(3-4):81–91. (In Russ.) Available at: https://www.antibiotics-chemotherapy.ru/jour/article/view/132.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Мухина МА, Леонова МВ. Новые пероральные лекарственные формы антибиотиков. Лечебное дело. 2012;(1):16–22. Режим доступа: https://elibrary.ru/oxbmrh.</mixed-citation><mixed-citation xml:lang="en">Mukhina MA, Leonova MV. New Oral Dosage Forms of Antibiotics. Lechebnoe Delo. 2012;(1):16–22. (In Russ.) Available at: https://elibrary.ru/oxbmrh.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Тихомиров АЛ, Казенашев ВВ, Маминова МВ, Давыденко НЛ. Оптимизация лечения вагинальной атрофии. Медицинский cовет. 2025;19(17):123–126. https://doi.org/10.21518/ms2025-452.</mixed-citation><mixed-citation xml:lang="en">Tikhomirov AL, Kazenashev VV, Maminova MV, Davydenko NL. Optimizing vaginal atrophy treatment. Meditsinskiy Sovet. 2025;19(17):123–126. (In Russ.) https://doi.org/10.21518/ms2025-452.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
