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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2026-119</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-10053</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GYNECOLOGY</subject></subj-group></article-categories><title-group><article-title>Прогнозирование преэклампсии у беременных с коморбидными состояниями</article-title><trans-title-group xml:lang="en"><trans-title>Prediction of preeclampsia in pregnant women with comorbid conditions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-1264-2931</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Руденко</surname><given-names>Д. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudenko</surname><given-names>D. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Руденко Дарья Борисовна, соискатель кафедры акушерства-гинекологии с курсом перинатологии</p><p>117198, Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Daria B. Rudenko, Candidate of the Department of Obstetrics and Gynecology with the Course of Perinatology</p><p>6, Miklukho-Maklai St., Moscow, 117198</p></bio><email xlink:type="simple">dariarudenko16@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6711-1563</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьева</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Solovyeva</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соловьева Алина Викторовна, д.м.н., профессор кафедры акушерства-гинекологии с курсом перинатологии</p><p>117198, Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Alina V. Solovyeva, Dr. Sci. (Med.), Professor at the Department of Obstetrics and Gynecology with the Course of Perinatology</p><p>6, Miklukho-Maklai St., Moscow, 117198</p></bio><email xlink:type="simple">av_soloveva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-3745-0042</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Спицына</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Spitsyna</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Спицына Мария Александровна, аспирант кафедры акушерства и гинекологии с курсом перинатологии</p><p>117198, Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Maria A. Spitsyna, Postgraduate Student of the Department of Obstetrics and Gynecology with the Course of Perinatology</p><p>6, Miklukho-Maklai St., Moscow, 117198</p></bio><email xlink:type="simple">lotyreva31@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3331-4033</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мамчич</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Mamchich</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мамчич Дарья Сергеевна, аспирант кафедры акушерства и гинекологии с курсом перинатологии</p><p>117198, Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Daria S. Mamchich, Postgraduate Student of the Department of Obstetrics and Gynecology with the Course of Perinatology</p><p>6, Miklukho-Maklai St., Moscow, 117198</p></bio><email xlink:type="simple">dasha.mamchich@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет дружбы народов имени Патриса Лумумбы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>RUDN University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>31</day><month>05</month><year>2026</year></pub-date><volume>20</volume><issue>5</issue><fpage>120</fpage><lpage>127</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Руденко Д.Б., Соловьева А.В., Спицына М.А., Мамчич Д.С., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Руденко Д.Б., Соловьева А.В., Спицына М.А., Мамчич Д.С.</copyright-holder><copyright-holder xml:lang="en">Rudenko D.B., Solovyeva A.V., Spitsyna M.A., Mamchich D.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/10053">https://www.med-sovet.pro/jour/article/view/10053</self-uri><abstract><sec><title>Введение</title><p>Введение. Преэклампсия является грозным осложнением беременности и одной из основных причин материнской и перинатальной заболеваемости и смертности. Важно выявлять женщин с высоким риском развития преэклампсии в I триместре беременности с целью своевременного терапевтического вмешательства. На данный момент не наблюдается значительного прогресса в области прогнозирования и профилактики данного осложнения беременности.</p></sec><sec><title>Цель</title><p>Цель. Составить прогноз возникновения преэклампсии у беременных с коморбидностью.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Был проведен ретроспективный анализ обменных карт и историй родов 158 жительниц Ставропольского края. Исследование проводилось на базе Ставропольского краевого клинического перинатального центра. Беременные (n = 158) были разделены на три группы: 1-я группа (n = 58) – беременные с избыточной массой тела или ожирением; 2-я группа (n = 70) – беременные с железодефицитной анемией (ЖДА) и избыточной массой тела или ожирением; 3-я группа (n = 60) – беременные с железодефицитной анемией и нормальной массой тела.</p></sec><sec><title>Результаты</title><p>Результаты. Беременные с ожирением и анемией имели более высокий риск возникновения вульвовагинального кандидоза (χ2 = 8,015, р = 0,019), преждевременных родов (χ2 = 7,431 р = 0,025) и преэклампсии (χ2 = 6,456, р = 0,040). Для беременных с ожирением наиболее значимыми факторами прогноза преэклампсии явились: первая беременность, уровень АЧТВ в III триместре. Для беременных с ЖДА факторы прогноза развития преэклампсии: первая беременность, табакокурение, уровень гемоглобина в I триместре. Для беременных с ожирением и ЖДА одновременно прогностическими критериями преэклампсии явились первая беременность и показатель тромбинового времени в III триместре.</p></sec><sec><title>Выводы</title><p>Выводы. Выявление прогностических критериев при отдельных факторах риска преэклампсии позволяет более точно оценить вероятность возникновения преэклампсии и своевременно решить вопрос о профилактике и начале терапии, а также способствовать устранению модифицируемых факторов риска преэклампсии, таких как ожирение и анемия.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Preeclampsia is a serious complication of pregnancy and one of the main causes of maternal and perinatal morbidity and mortality. It is important to identify women at high risk of developing preeclampsia in the first trimester of pregnancy in order to provide timely therapeutic intervention. At the moment, there is no significant progress in predicting and preventing this complication of pregnancy.</p></sec><sec><title>Aim</title><p>Aim. To predict the occurrence of preeclampsia in pregnant women with comorbidity.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A retrospective analysis of the exchange cards and birth histories of 158 residents of the Stavropol Territory was conducted. The study was conducted on the basis of the Stavropol Regional Clinical Perinatal Center in Stavropol, Stavropol Territory. Pregnant women (n = 158) were divided into three groups: the first group (n = 58) – pregnant women with overweight or obesity; group 2 (n = 70) – pregnant women with iron deficiency anemia and overweight or obesity; group 3 (n = 60) – pregnant women with iron deficiency anemia and normal body weight.</p></sec><sec><title>Results</title><p>Results. Pregnant women with obesity and anemia had a higher risk of vulvovaginal candidiasis (χ2 = 8.015, p = 0.019), premature birth (χ2 = 7.431, p = 0.025) and preeclampsia (χ2 = 6.456, p = 0.040). For obese pregnant women, the most significant factors in the prognosis of preeclampsia were: the first pregnancy, the APTT level in the third trimester. For pregnant women with IDA, factors predicting the development of preeclampsia: first pregnancy, smoking, hemoglobin levels in the first trimester. For pregnant women with obesity and IDA, the prognostic criteria for preeclampsia were: the first pregnancy, and the indicator of thrombin time in the third trimester.</p></sec><sec><title>Conclusions</title><p>Conclusions. The identification of prognostic criteria for individual risk factors for preeclampsia makes it possible to more accurately assess the likelihood of preeclampsia and timely resolve the issue of prevention and initiation of therapy and contribute to the elimination of modifiable risk factors for preeclampsia, such as obesity and anemia.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>беременность</kwd><kwd>преэклампсия</kwd><kwd>железодефицитная анемия</kwd><kwd>ожирение</kwd><kwd>коморбидность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pregnancy</kwd><kwd>preeclampsia</kwd><kwd>iron deficiency anemia</kwd><kwd>obesity</kwd><kwd>comorbidity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Roberts JM. Preeclampsia epidemiology(ies) and pathophysiology(ies). 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