medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2026-062medsovet-10093Research ArticleЭНДОКРИНОЛОГИЯENDOCRINOLOGYНовые данные по постковидному синдрому у пациентов с сахарным диабетом 2-го типаEmerging evidence on post-COVID syndrome in patients with type 2 diabeteshttps://orcid.org/0000-0002-7080-8713СухановC. А.SukhanovS. A.

Суханов Сергей Александрович, ассистент кафедры терапии и общей врачебной практики

603005, Нижний Новгород, площадь Минина и Пожарского, д. 10/1

Sergey A. Sukhanov, Assistent of the Department of Therapy and General Medical Practice

0/1, Minin and Pozharsky Square, Nizhny Novgorod, 60395

sukhanov.aleck@yandex.ruhttps://orcid.org/0000-0003-1830-3600ЗанозинаО. В.ZanozinaO. V.

Занозина Ольга Владимировна, д.м.н., доцент, профессор кафедры терапии и общей врачебной практики, Приволжский исследовательский медицинский университет; заведующая эндокринологическим отделением, Нижегородская областная клиническая больница имени Н.А. Семашко

603005, Нижний Новгород, площадь Минина и Пожарского, д. 10/1,

603126, Нижний Новгород, ул. Родионова, д. 190

Olga V. Zanozina, Dr. Sci. (Med.), Associate Professor, Professor of the Department of Therapy and General Medical Practice, Privolzhsky Research Medical University; Head of the Endocrinology Department, Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko

10/1, Minin and Pozharsky Square, Nizhny Novgorod, 603950,

190, Rodionov St., Nizhny Novgorod, 603126

zwx2@mail.ruСорокинаЮ. А.SorokinaYu. A.

Сорокина Юлия Андреевна, к.б.н., доцент кафедры общей и клинической фармакологии

603005, Нижний Новгород, площадь Минина и Пожарского, д. 10/1

Yulia A. Sorokina, Cand. Sci. (Biol.), Associate Professor of the Department of General and Clinical Pharmacology

0/1, Minin and Pozharsky Square, Nizhny Novgorod, 60395

ЛагонскаяВ. Н.LagonskayaV. N.

Лагонская Вероника Николаевна, к.б.н., заведующая отделением клинико-лабораторной диагностики

603126, Нижний Новгород, ул. Родионова, д. 190

Veronika N. Lagonskaya, Cand. Sci. (Biol.), Head of the Department of Clinical Laboratory Diagnostics

190, Rodionov St., Nizhny Novgorod, 603126

КобалаваМ. В.KobalavaM. V.

Кобалава Мери Вепхиаевна, врач-биолог отделения клинико-лабораторной диагностики

603126, Нижний Новгород, ул. Родионова, д. 190

Meri V. Kobalava, Biologist, Department of Clinical Laboratory Diagnostics

190, Rodionov St., Nizhny Novgorod, 603126

mery.mery@mail.ruПриволжский исследовательский медицинский университетРоссияPrivolzhsky Research Medical UniversityRussian FederationПриволжский исследовательский медицинский университет; Нижегородская областная клиническая больница имени Н.А. СемашкоРоссияPrivolzhsky Research Medical University; Nizhny Novgorod Regional Clinical Hospital named after N.A. SemashkoRussian FederationНижегородская областная клиническая больница имени Н.А. СемашкоРоссияNizhny Novgorod Regional Clinical Hospital named after N.A. SemashkoRussian Federation202631052026205174182Copyright © Суханов C.А., Занозина О.В., Сорокина Ю.А., Лагонская В.Н., Кобалава М.В., 20262026Суханов C.А., Занозина О.В., Сорокина Ю.А., Лагонская В.Н., Кобалава М.В.Sukhanov S.A., Zanozina O.V., Sorokina Y.A., Lagonskaya V.N., Kobalava M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/10093

Пандемия новой коронавирусной инфекции, затронувшая мир, прошла, но проблемы сохранились до сих пор. Долгосрочные последствия COVID-19 остаются недостаточно изученными в настоящее время. Термин «постковидный синдром» (ПКС) в настоящее время имеет временную составляющую, клинико-лабораторную составляющую, определены некоторые биомолекулярные маркеры, факторы риска развития данного осложнения после перенесенной коронавирусной инфекции, уточняется генетическая составляющая постковидного синдрома. Вместе с тем относительно постковидного синдрома у пациентов с сахарным диабетом 2-го типа (СД2) данные разноречивые: например, данные по распространенности постковидных нарушений очень отличаются даже в пределах одной страны. В среднем в Европе частота ПКС у пациентов с СД2 – 66,8%, причем максимальная частота – в возрасте 50 лет. Появляются новые биомаркеры постковидного синдрома у пациентов с СД2, разрабатываются прогностические критерии его развития у данной категории пациентов. Показано, что у пациентов с СД2 и постковидным синдромом длина теломер была достоверно меньше, чем у лиц без постковидных нарушений. Критерием данного синдрома могут служить высокие уровни подоцит-специфических белков и нейтрофильной эластазы. Нами оценена значимость некоторых лейкоцитарных индексов в диагностике и мониторировании последствий перенесенной новой коронавирусной инфекции у пациентов с СД2. Однако остается еще много нерешенных вопросов, в частности, есть ли генетическая предрасположенность к развитию хронического ковида у пациентов с сахарным диабетом. Ранее нами был проведен аналитический обзор по наличию ПКС у пациентов с СД2. Целью настоящей публикации явилось желание обобщить появившиеся в литературе новые данные по основным пунктам, изложенным ранее, и представить собственные результаты.

The novel coronavirus pandemic that ravaged the world has passed, but challenges remain. The long-term consequences of COVID-19 are remain poorly understood. The term “post-COVID syndrome” currently has a temporal component, a clinical and laboratory component, some biomolecular markers have been identified, risk factors for the development of this complication after a coronavirus infection have been determined, and the genetic component of post-COVID syndrome is being clarified. However, regarding post-COVID syndrome in patients with type 2 diabetes, the data are conflicting. Data on the prevalence of post-COVID disorders vary widely, even within a single country. On average, in Europe, the frequency of PCOS in patients with type 2 diabetes is 66.8%, with the maximum frequency being at the age of 50 years. New biomarkers of post-COVID syndrome in patients with type 2 diabetes are emerging, and prognostic criteria for its development in this category of patients are being developed. It was shown that the telomere length was significantly shorter in patients with type 2 diabetes mellitus and post-COVID syndrome than in individuals without post-COVID disorders. High levels of podocyte-specific proteins and neutrophil elastase can serve as criteria for this syndrome. We assessed the significance of some leukocyte indices in the diagnosis and monitoring of the consequences of a new coronavirus infection in patients with type 2 diabetes. However, many unanswered questions remain, in particular, whether there is a genetic predisposition to the development of chronic COVID-19 in patients with diabetes. We previously conducted an analytical review of the presence of PCS in patients with type 2 diabetes. The purpose of this publication was to summarize new data in the literature on the main points outlined previously and to present our own results.

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The authors declare that there are no conflicts of interest present.