medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2026-014medsovet-10104Research ArticleКОМОРБИДНЫЙ ПАЦИЕНТCOMORBID PATIENTКоморбидность заболеваний пародонта и болезни АльцгеймераComorbidity of periodontal diseases and Alzheimer’s diseasehttps://orcid.org/0000-0002-1597-1876ТруханД. И.TrukhanD. I.

Трухан Дмитрий Иванович, д.м.н., доцент, профессор кафедры поликлинической терапии и внутренних болезней

644043, Омск, ул. Ленина, д. 12

Dmitry I. Trukhan, Dr. Sci. (Med.), Associate Professor, Professor of the Chair of Polyclinic Therapy and Internal Diseases

12, Lenin St., Omsk, 644043

dmitry_trukhan@mail.ruhttps://orcid.org/0009-0004-3249-3425СулимовА. Ф.SulimovA. F.

Сулимов Анатолий Филиппович, д.м.н., профессор, заведующий кафедрой челюстно-лицевой хирургии

644043, Омск, ул. Ленина, д. 12

Anatoly F. Sulimov, Dr. Sci. (Med.), Professor, Head of the Department of Maxillofacial Surgery

12, Lenin St., Omsk, 644043

afsulimov@yandex.ruhttps://orcid.org/0000-0002-4721-6605ТруханЛ. Ю.TrukhanL. Yu.

Трухан Лариса Юрьевна, к.м.н., врач-стоматолог, ассистент кафедры челюстно-лицевой хирургии

644043, Омск, ул. Ленина, д. 12

Larisa Yu. Trukhan, Cand. Sci. (Med.), Dentist, Assistant Professor of the Department of Maxillofacial Surgery

12, Lenin St., Omsk, 644043

larissa_trukhan@mail.ruhttps://orcid.org/0000-0002-7695-149XРожковаМ. Ю.RozhkovaM. Yu.

Рожкова Мария Юрьевна, к.м.н., доцент кафедры поликлинической терапии и внутренних болезней

644043, Омск, ул. Ленина, д. 12

Mariia Yu. Rozhkova, Cand. Sci. (Med.), Associate Professor of the Department of Polyclinic Therapy and Internal Diseases

12, Lenin St., Omsk, 644043

marroj@mail.ruОмский государственный медицинский университетРоссияOmsk State Medical UniversityRussian Federation202631052026205270280Copyright © Трухан Д.И., Сулимов А.Ф., Трухан Л.Ю., Рожкова М.Ю., 20262026Трухан Д.И., Сулимов А.Ф., Трухан Л.Ю., Рожкова М.Ю.Trukhan D.I., Sulimov A.F., Trukhan L.Y., Rozhkova M.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/10104

Заболевания пародонта относятся к числу наиболее распространенных заболеваний человека. В начале XXI в. сформировалась концепция «пародонтальной медицины», рассматривающая взаимосвязи патологии пародонта с другими заболеваниями организма. Сегодня с патологией пародонта связано более 50 различных системных заболеваний. Болезнь Альцгеймера является наиболее распространенной формой первичных дегенеративных деменций позднего возраста. К 2050 г. в мире число случаев достигнет уровня 140 млн. Анатомическая близость полости рта и головного мозга предполагает наличие связи между заболеваниями пародонта и патологией ЦНС. Авторы провели поиск источников в информационной базе Pubmed, опубликованных до 19.10.2025, в которых рассматривалась взаимосвязь патологии пародонта и болезни Альцгеймера. Было найдено 630 публикаций. В настоящем исследовании авторы проанализировали 121 публикацию из 423 источников, опубликованных за последние 5 лет. Полученные в ходе анализа данные свидетельствуют о связи болезни Альцгеймера с заболеваниями пародонта, наличии эпидемиологических и генетических параллелей, патогенетических взаимосвязях, подтвержденных клиническими и экспериментальными исследованиями. Porphyromonas gingivalis, посредством множества факторов вирулентности, выступает в качестве ключевого патогена при болезни Альцгеймера и пародонтите. Выполненный анализ исследований, проведенных учеными за последние 5 лет, позволяет сделать вывод о важности междисциплинарных подходов в понимании системных последствий заболеваний пародонта и их потенциального влияния на здоровье мозга. Взаимосвязь заболеваний пародонта и болезни Альцгеймера позволяет рассматривать здоровье полости рта как важный фактор в профилактике и в лечении болезни Альцгеймера.

Periodontal diseases are among the most common human ailments. At the beginning of the 21st century, the concept of “periodontal medicine” emerged, examining the relationship between periodontal pathology and other diseases of the body. Today, periodontal pathology is associated with more than 50 different systemic diseases. Alzheimer's disease is the most common form of primary degenerative dementia in late life. By 2050, the number of cases worldwide will reach 140 million. The anatomical proximity of the oral cavity and brain suggests a link between periodontal disease and CNS pathology. The authors searched the Pubmed database for sources published before October 19, 2025, that examined the relationship between periodontal pathology and Alzheimer's disease. A total of 630 publications were identified. In the present study, the authors analyzed 121 publications out of 423 sources published over the past 5 years. The data obtained during the analysis demonstrate a link between Alzheimer's disease and periodontal disease, the presence of epidemiological and genetic parallels, and pathogenetic relationships confirmed by clinical and experimental studies. Porphyromonas gingivalis, through multiple virulence factors, acts as a key pathogen in Alzheimer's disease and periodontitis. The analysis of research conducted by scientists over the past five years suggests the importance of interdisciplinary approaches in understanding the systemic consequences of periodontal disease and its potential impact on brain health. The relationship between periodontal disease and Alzheimer's disease suggests that oral health is an important factor in the prevention and treatment of Alzheimer's disease.

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The authors declare that there are no conflicts of interest present.