medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2013-12-50-54medsovet-1163Research ArticleНЕРВНО-ПСИХИЧЕСКИЕ РАССТРОЙСТВАNEUROPSYCHIATRIC DISORDERSНекоторые аспекты базовой симптоматической терапии когнитивных нарушений разной степени тяжестиSome aspects of the background symptomatic treatment of cognitive impairment of various severity typesПреображенскаяИ. С.PreobrazhenskayaI. S.noemail@neicon.ruМГМУ им. И.М. СеченоваРоссияFirst MSMU named after I.M.SechenovRussian Federation2013301220130125054Copyright © Преображенская И.С., 20132013Преображенская И.С.Preobrazhenskaya I.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/1163

В представленном обзоре литературы отмечается роль глутаматергических нарушений в патогенезе когнитивных расстройств. Приводятся данные об эффективности антагониста глутаматных NMDA-рецепторов мемантина у пациентов с различными деменциями: болезнью Альцгеймера, деменцией с тельцами Леви, сосудистой и смешанной деменцией. Описан собственный положительный опыт применения препарата Акатинол Мемантин при различных деменциях. Обсуждаются возможности применения этого лекарственного препарата у пациентов с умеренными когнитивными нарушениями; приведены результаты многоцентрового регионального исследования. Отмечается эффективность и безопасность применения Акатинола Мемантина в качестве средства, улучшающего когнитивные функции.

This literature review outlines the role of glutamatergic disturbances in the pathogenesis of cognitive disorders. There is data on the effectiveness of the glutamate NMDA-receptors antagonist - memantine - in patients with various dementias: Alzheimer's disease, dementia with Lewy bodies, vascular and mixed dementia. The authors share own positive experience with the drug Akatinol Memantine at various dementias. Options for administration of the drug in patients with mild cognitive impairment are discussed; results of a multicenter regional study are provided. The efficacy and safety of Akatinol Memantine as a medication to improve cognitive function is highlighted.

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The authors declare that there are no conflicts of interest present.