<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2014-14-18-21</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-1232</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АЛЛЕРГОЛОГИЯ И ИММУНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ALLERGOLOGY AND IMMUNOLOGY</subject></subj-group></article-categories><title-group><article-title>Профилактика респираторных инфекций у детей</article-title><trans-title-group xml:lang="en"><trans-title>Prevention of respiratory infections in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колосова</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolosova</surname><given-names>N. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>the First Moscow State Medical University named after I.M. Sechenov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2014</year></pub-date><volume>0</volume><issue>14</issue><fpage>18</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Колосова Н.Г., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Колосова Н.Г.</copyright-holder><copyright-holder xml:lang="en">Kolosova N.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/1232">https://www.med-sovet.pro/jour/article/view/1232</self-uri><abstract><p>Респираторные инфекции остаются серьезной проблемой педиатрии в связи с их широкой распространенностью и наносимым экономическим ущербом как отдельным лицам, так и обществу в целом, поскольку в структуре инфекционной заболеваемости на их долю приходится от 60 до 90% всей детской инфекционной заболеваемости. Они регистрируются повсеместно и в любое время года, но массовый характер приобретают во время сезонного подъема заболеваемости с октября по март. Хотя большинство острых респираторных заболеваний (ОРЗ) имеет легкое течение и не дает осложнений, они ухудшают самочувствие детей, препятствуют их повседневной активности [<xref ref-type="bibr" rid="cit3">3</xref>].</p></abstract><trans-abstract xml:lang="en"><p>Respiratory infections remain a challenge in pediatrics because of their high prevalence and economic burden both for individuals and society as a whole, as they account for 60 to 90% of all infectious diseases in children among infectious diseases. They are recorded everywhere and all year round, reaching epidemic proportions during the seasonal morbidity rise from October to March. Although the majority of acute respiratory infections (ARI) are mild course and cause no complications, they impair well being of children and hinder their daily activities [<xref ref-type="bibr" rid="cit3">3</xref>].</p></trans-abstract><kwd-group xml:lang="ru"><kwd>респираторные инфекции</kwd><kwd>дети</kwd><kwd>профилактика</kwd><kwd>бактериальные иммуномодуляторы</kwd><kwd>Рибомунил</kwd><kwd>respiratory infections</kwd><kwd>children</kwd><kwd>prevention</kwd><kwd>bacterial immunomodulators</kwd><kwd>Ribomunyl</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Афиногенова В.П., Лукачев И.В., Костинов М.П. Иммунотерапия: механизм действия и клиническое применение иммунокорригирующих препаратов. Лечащий врач, 2010, 4.</mixed-citation><mixed-citation xml:lang="en">Афиногенова В.П., Лукачев И.В., Костинов М.П. Иммунотерапия: механизм действия и клиническое применение иммунокорригирующих препаратов. Лечащий врач, 2010, 4.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Богомолова И.К., Носков КГ. Эффективность вакцинотерапии рибомунилом у больных бронхиальной астмой. Забайкальский медицинский вестник, 2010, 1: 3-5.</mixed-citation><mixed-citation xml:lang="en">Богомолова И.К., Носков КГ. Эффективность вакцинотерапии рибомунилом у больных бронхиальной астмой. Забайкальский медицинский вестник, 2010, 1: 3-5.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Волков И.К., Геппе Н.А., Фролкова Е.В., Шахназарова М.Д. Применение рибосомальной вакцины (Рибомунил) в профилактике респираторных заболеваний у детей. Фарматека, 2014, 3: 66-71.</mixed-citation><mixed-citation xml:lang="en">Волков И.К., Геппе Н.А., Фролкова Е.В., Шахназарова М.Д. Применение рибосомальной вакцины (Рибомунил) в профилактике респираторных заболеваний у детей. Фарматека, 2014, 3: 66-71.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Коровина Н.А., Чебуркин А.В., Заплатников А.Л., Захарова И.Н. Иммунокорригирующая терапия часто и длительно болеющих детей.</mixed-citation><mixed-citation xml:lang="en">Коровина Н.А., Чебуркин А.В., Заплатников А.Л., Захарова И.Н. Иммунокорригирующая терапия часто и длительно болеющих детей.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Опыт применения Рибомунила в российской педиатрической практике. Сборник научных трудов. Под ред. Н.А. Коровиной. М., 2002.</mixed-citation><mixed-citation xml:lang="en">Опыт применения Рибомунила в российской педиатрической практике. Сборник научных трудов. Под ред. Н.А. Коровиной. М., 2002.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Пикуза О.И., Закирова А.М., Хакимова А.Ф. Клинико-иммунологическая эффективность бактериальных лизатов у часто болеющих детей. РМЖ, 2012, 96(2): 45-47.</mixed-citation><mixed-citation xml:lang="en">Пикуза О.И., Закирова А.М., Хакимова А.Ф. Клинико-иммунологическая эффективность бактериальных лизатов у часто болеющих детей. РМЖ, 2012, 96(2): 45-47.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bellami JA, Olivieri D, Seranno E. Ribosomal immunostimulation: assessment of studies evaluating its clinical relevance in the prevention ol upper and lower respiratory tract infections in children and adults. BioDrugs, 2003, 17: 355-367.</mixed-citation><mixed-citation xml:lang="en">Bellami JA, Olivieri D, Seranno E. Ribosomal immunostimulation: assessment of studies evaluating its clinical relevance in the prevention ol upper and lower respiratory tract infections in children and adults. BioDrugs, 2003, 17: 355-367.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bousquet J, Fiocchi A. Prevention of recurrent respiratory tract infections in children using a ribosomal immunotherapeutic agent: a clinical review. Paediatr. Drugs. 2006, 8(4): 235-43.</mixed-citation><mixed-citation xml:lang="en">Bousquet J, Fiocchi A. Prevention of recurrent respiratory tract infections in children using a ribosomal immunotherapeutic agent: a clinical review. Paediatr. Drugs. 2006, 8(4): 235-43.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Boyle P, Bellanto JA, Robertson C. Mela-analysis of published clinical trials of a ribosomal vaccine (Ribomunyl® in prevention of respiratory infections. BioDrugs. 2000, 14: 389-408.</mixed-citation><mixed-citation xml:lang="en">Boyle P, Bellanto JA, Robertson C. Mela-analysis of published clinical trials of a ribosomal vaccine (Ribomunyl® in prevention of respiratory infections. BioDrugs. 2000, 14: 389-408.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Cahot E, Libon C, Kernels S el al. Translocation of ribosomal immuno-stimulant through an in vitro-reconstituted digestive barrier containing M-like cells. Scand.J. Immunol. 2000, 52: 588-94.</mixed-citation><mixed-citation xml:lang="en">Cahot E, Libon C, Kernels S el al. Translocation of ribosomal immuno-stimulant through an in vitro-reconstituted digestive barrier containing M-like cells. Scand.J. Immunol. 2000, 52: 588-94.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Del-Rio-Navarro BE, Espinosa-Rosales FJ, Flenady V, Sienra-Monge JJL Immunostimulants for preventing respiratory tract infection in children. Cochrane Database Systematic Rev. 2006, Issue 4: CD004974.</mixed-citation><mixed-citation xml:lang="en">Del-Rio-Navarro BE, Espinosa-Rosales FJ, Flenady V, Sienra-Monge JJL Immunostimulants for preventing respiratory tract infection in children. Cochrane Database Systematic Rev. 2006, Issue 4: CD004974.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Jongmans W, Tiemessen DM, van Vlodrop IJ et al. Th1-polarizing capacity of clinical-grade dendritic cells triggered by Ribomunyl but is compromised by PGE2.J. Immunother. 2005, 28: 480-87.</mixed-citation><mixed-citation xml:lang="en">Jongmans W, Tiemessen DM, van Vlodrop IJ et al. Th1-polarizing capacity of clinical-grade dendritic cells triggered by Ribomunyl but is compromised by PGE2.J. Immunother. 2005, 28: 480-87.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Zanib C, Bene MC, Perruchet AM et al. Bacterial crude extracts of ribosomes are recognized similary by peripheral and mucosal B cells. PPMS Immunol. Med. Microbiol. 1994, 10: 11-8.</mixed-citation><mixed-citation xml:lang="en">Zanib C, Bene MC, Perruchet AM et al. Bacterial crude extracts of ribosomes are recognized similary by peripheral and mucosal B cells. PPMS Immunol. Med. Microbiol. 1994, 10: 11-8.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
