medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2016-13-99-101medsovet-1371Research ArticleДИССЕРТАНТDISSERTANTУчастие микроорганизма Helicobacter pylori в развитии сердечно-сосудистой патологииPARTICIPATION OF THE MICROORGANISM HELICOBACTER PYLORI IN THE DEVELOPMENT OF CARDIOVASCULAR DISEASEАХМЕДОВВ. А.AKHMEDOVV. A.

д.м.н., профессор

MD, professor

ГАУСО. В.GAUSO. V.

Assistant of the Department

Омский государственный медицинский университетРоссияOmsk State Medical UniversityRussian Federation20163012201601399101Copyright © АХМЕДОВ В.А., ГАУС О.В., 20162016АХМЕДОВ В.А., ГАУС О.В.AKHMEDOV V.A., GAUS O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/1371

Представлен обзор литературы по актуальным вопросам факторов формирования поражения сердечно-сосудистой системы у лиц, инфицированных микроорганизмом Helicobacter pylori. Проведена оценка влияние инфицирования на различные клинические проявления атеросклероза, артериальной гипертензии, фибрилляции предсердий, инфаркта миокарда.

A review of the literature dedicated to topical issues of the factors forming the defeat of the cardiovascular system in individuals infected with the microorganism Helicobacter pylori. The evaluation of the impact of infection on the various clinical manifestations of atherosclerosis, hypertension, atrial fibrillation, myocardial infarction were made.

Helicobacter pyloriсердечно-сосудистая патологияатеросклерозHelicobacter pyloricardiovascular diseaseatherosclerosisReferencesCook P.J., Lip G.Y. Infectious agents and atherosclerotic vascular disease. QJM 1996; 89: 727-735.Cook P.J., Lip G.Y. Infectious agents and atherosclerotic vascular disease. QJM 1996; 89: 727-735.Zhang S., Guo Y., Ma Y., Teng Y. Cytotoxinassociated gene-A-seropositive virulent strains of Helicobacter pylori and atherosclerotic diseases: a systematic review. Chin Med J (Engl) 2008; 121: 946-951.Zhang S., Guo Y., Ma Y., Teng Y. Cytotoxinassociated gene-A-seropositive virulent strains of Helicobacter pylori and atherosclerotic diseases: a systematic review. Chin Med J (Engl) 2008; 121: 946-951.Saton H., Saijo Y., Yoshioka E., Tsutsui H. Helicobacter Pylori infection is a significant risk for modified lipid profile in Japanese male subjects. J Atheroscler Thromb 2010; 17: 1041-1048.Saton H., Saijo Y., Yoshioka E., Tsutsui H. Helicobacter Pylori infection is a significant risk for modified lipid profile in Japanese male subjects. J Atheroscler Thromb 2010; 17: 1041-1048.Kucukazman M., Yavuz B., Sacikara M. et al. The relationship between updated Sydney System score and LDL cholesterol levels in patients infected with Helicobacter pylori. Dig Dis Sci 2009; 54: 604-607.Kucukazman M., Yavuz B., Sacikara M. et al. The relationship between updated Sydney System score and LDL cholesterol levels in patients infected with Helicobacter pylori. Dig Dis Sci 2009; 54: 604-607.Pellicano R., Oliaro E., Fagoonee S. et al. Clinical and biochemical parameters related to cardiovascular disease after Helicobacter pylori eradication. Int Angiol 2009; 28: 469-473.Pellicano R., Oliaro E., Fagoonee S. et al. Clinical and biochemical parameters related to cardiovascular disease after Helicobacter pylori eradication. Int Angiol 2009; 28: 469-473.Lindquist S., Craig E.A. The heat-shock proteins. Annu Rev Genet 1988; 22: 631-677.Lindquist S., Craig E.A. The heat-shock proteins. Annu Rev Genet 1988; 22: 631-677.Lenzi C., Palazzuolia A., GiorrdanoI N. et al. H. pylori infection and systemic antibodies to CagA and heat shock protein 60 in patients with coronary heart disease. World. J. Gastroenterol. 2006; 12: 7815-7820.Lenzi C., Palazzuolia A., GiorrdanoI N. et al. H. pylori infection and systemic antibodies to CagA and heat shock protein 60 in patients with coronary heart disease. World. J. Gastroenterol. 2006; 12: 7815-7820.Niccoli G., Franceschi F., Cosentino N. et al. Coronary atherosclerotic burden in patients with infection by CagA-positive strains of Helicobacter pylori. Coron Artery Dis 2010; 21: 217-221.Niccoli G., Franceschi F., Cosentino N. et al. Coronary atherosclerotic burden in patients with infection by CagA-positive strains of Helicobacter pylori. Coron Artery Dis 2010; 21: 217-221.Antobiades C., Antonopoulos A.S., Tousoulis D. et al. Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J 2009; 30: 6- 15.Antobiades C., Antonopoulos A.S., Tousoulis D. et al. Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J 2009; 30: 6- 15.Torisu T., Takata Y., Ansai T. et al. Possible association of atrophic gastritis and arterial stiffness in healthy middleaged Japanese. J Atheroscler Thromb 2009; 16: 691-697.Torisu T., Takata Y., Ansai T. et al. Possible association of atrophic gastritis and arterial stiffness in healthy middleaged Japanese. J Atheroscler Thromb 2009; 16: 691-697.Senmaru T., Fukui M., Tanaka M. et al. Atrophic gastritis is associated with coronary artery disease. J Clin Biochem Nutr 2012; 51: 39-41.Senmaru T., Fukui M., Tanaka M. et al. Atrophic gastritis is associated with coronary artery disease. J Clin Biochem Nutr 2012; 51: 39-41.Yoshikawa H., Aida K., Mori A. et al. Involvement of Helicobacter pylori infection and impaired glucose metabolism in the increase of brachial-ankle pulse wave velocity. Helicobacter 2007; 12: 559-566.Yoshikawa H., Aida K., Mori A. et al. Involvement of Helicobacter pylori infection and impaired glucose metabolism in the increase of brachial-ankle pulse wave velocity. Helicobacter 2007; 12: 559-566.de Luis D.A., Lahera M., Cantón R. et al. Association of Helicobacter pylori infection with cardiovascular and cerebrovascular disease in diabetic patients. Diabetes Care 1998; 21: 1129-1132.de Luis D.A., Lahera M., Cantón R. et al. Association of Helicobacter pylori infection with cardiovascular and cerebrovascular disease in diabetic patients. Diabetes Care 1998; 21: 1129-1132.Gen R., Demir M., Ataseven H. Effect of Helicobacter pylori eradication on insulin resistance, serum lipids and low-grade inflammation. South Med J. 2010; 103: 190-196.Gen R., Demir M., Ataseven H. Effect of Helicobacter pylori eradication on insulin resistance, serum lipids and low-grade inflammation. South Med J. 2010; 103: 190-196.Naja F., Nasreddine L., Hwalla N. et al. Association of H. pylori infection with insulin resistance and metabolic syndrome among Lebanese adults. Helicobacter 2012; 17: 444- 451.Naja F., Nasreddine L., Hwalla N. et al. Association of H. pylori infection with insulin resistance and metabolic syndrome among Lebanese adults. Helicobacter 2012; 17: 444- 451.Adachi K., Arima N., Takashima T. et al. Pulsewave velocity and cardiovascular risk factors on subjects with Helicobacter pylori infection. J Gastroenterol Hepatol 2003; 18: 771-777. 17. Migneco A., Ojetti V., Specchia L. et al. Eradication of Helicobacter pylori infection improves blood pressure values in patients affected by hypertension. Helicobacter 2003; 8: 585-589.Adachi K., Arima N., Takashima T. et al. Pulsewave velocity and cardiovascular risk factors on subjects with Helicobacter pylori infection. J Gastroenterol Hepatol 2003; 18: 771-777. 17. Migneco A., Ojetti V., Specchia L. et al. Eradication of Helicobacter pylori infection improves blood pressure values in patients affected by hypertension. Helicobacter 2003; 8: 585-589.Danesh J., Youngman L., Clark S. et al. Helicobacter pylori infection and early onset myocardial infarction: case-control and sibling pairs study. BMJ 1999; 319: 1157-1162.Danesh J., Youngman L., Clark S. et al. Helicobacter pylori infection and early onset myocardial infarction: case-control and sibling pairs study. BMJ 1999; 319: 1157-1162.Alkout A.M., Ramsay E.J., Mackenzie D.A. et al, Quantitative assessment of IgG antibodies to Helicobacter pylori and outcome of ischaemic heart disease. FEMS Immunol Med Microbiol 2000; 29: 271-274.Alkout A.M., Ramsay E.J., Mackenzie D.A. et al, Quantitative assessment of IgG antibodies to Helicobacter pylori and outcome of ischaemic heart disease. FEMS Immunol Med Microbiol 2000; 29: 271-274.Kinjo K., Sato H., Sato H. et al. Prevalence of Helicobacter pylori infection and its link to coronary risk factors in Japanese patients with acute myocardial infarction. Circ J 2002; 66: 805-810.Kinjo K., Sato H., Sato H. et al. Prevalence of Helicobacter pylori infection and its link to coronary risk factors in Japanese patients with acute myocardial infarction. Circ J 2002; 66: 805-810.Gabrielli M., Santoliquido A., Cremonini F. et al. CagA-positive cytotoxic H. pylori strains as a link between plaque instability and atherosclerotic stroke. Eur Heart J 2004; 25: 64-68.Gabrielli M., Santoliquido A., Cremonini F. et al. CagA-positive cytotoxic H. pylori strains as a link between plaque instability and atherosclerotic stroke. Eur Heart J 2004; 25: 64-68.De Bastiani R., Gabrielli M., Ubaldi E. et al. High prevalence of Cag-A positive H. pylori strains in ischemic stroke: a primary care multicenter study. Helicobacter 2008; 13: 274-277.De Bastiani R., Gabrielli M., Ubaldi E. et al. High prevalence of Cag-A positive H. pylori strains in ischemic stroke: a primary care multicenter study. Helicobacter 2008; 13: 274-277.Kowalski M. Helicobacter pylori (H. pylori) infection in coronary artery disease: influence of H. pylori eradication on coronary artery lumen after percutaneous transluminal coronary angioplasty. The detection of H. pylori specific DNA in human coronary atherosclerotic plaque. J Physiol Pharmacol 2001; 52: 3-31.Kowalski M. Helicobacter pylori (H. pylori) infection in coronary artery disease: influence of H. pylori eradication on coronary artery lumen after percutaneous transluminal coronary angioplasty. The detection of H. pylori specific DNA in human coronary atherosclerotic plaque. J Physiol Pharmacol 2001; 52: 3-31.Bloemenkamp D.G., Mali W.P., Tanis B.C. et al. Chlamydia pneumoniae, Helicobacter pylori and cytomegalovirus infections and the risk of peripheral arterial disease in young women. Atherosclerosis 2002; 163: 149-156.Bloemenkamp D.G., Mali W.P., Tanis B.C. et al. Chlamydia pneumoniae, Helicobacter pylori and cytomegalovirus infections and the risk of peripheral arterial disease in young women. Atherosclerosis 2002; 163: 149-156.Sawayama Y., Hamada M., Otaguro S. et al. Chronic Helicobacter pylori infection is associated with peripheral arterial disease. J Infect Chemother 2008; 14: 250-254.Sawayama Y., Hamada M., Otaguro S. et al. Chronic Helicobacter pylori infection is associated with peripheral arterial disease. J Infect Chemother 2008; 14: 250-254.Wang D., Chen W., Yang S. Et al. Helicobacter pylori infection in Chinese patients with atrial fibrillation. Clinical Interventions in Aging 2015:10 813–819.Wang D., Chen W., Yang S. Et al. Helicobacter pylori infection in Chinese patients with atrial fibrillation. Clinical Interventions in Aging 2015:10 813–819.Pirat B., Atar I., Ertan C. et al. Comparison of C-reactive protein levels in patients who do and do not develop atrial fibrillation during electrophysiologic study. Am J Cardiol. 2007; 100: 1552–1555.Pirat B., Atar I., Ertan C. et al. Comparison of C-reactive protein levels in patients who do and do not develop atrial fibrillation during electrophysiologic study. Am J Cardiol. 2007; 100: 1552–1555.Sharma D., Li G., Xu G et al. Atrial remodeling in atrial fibril lation and some related microRNAs. Cardiology. 2011;120:111–121.Sharma D., Li G., Xu G et al. Atrial remodeling in atrial fibril lation and some related microRNAs. Cardiology. 2011;120:111–121.Ki M.R., Shin D.G., Park J.S. et al. Frequency of vacuolating cytotoxin A (VacA)-positive Helicobacter pylori seropositivity and TGF-β1 decrease in atrial fibrillation. Int J Cardiol. 2010; 145: 345–346.Ki M.R., Shin D.G., Park J.S. et al. Frequency of vacuolating cytotoxin A (VacA)-positive Helicobacter pylori seropositivity and TGF-β1 decrease in atrial fibrillation. Int J Cardiol. 2010; 145: 345–346.Ameriso S.F., Fridman E.A., Leiguarda R.C. et al. Detection of Helicobacter pylori in human carotid atherosclerotic plaques. Stroke 2001; 32: 385-391.Ameriso S.F., Fridman E.A., Leiguarda R.C. et al. Detection of Helicobacter pylori in human carotid atherosclerotic plaques. Stroke 2001; 32: 385-391.Izadi M., Fazel M., Sharubandi S.H. et al. Helicobacter species in the atherosclerotic plaques of patients with coronary artery disease. Cardiovasc Pathol 2012; 21: 307-311.Izadi M., Fazel M., Sharubandi S.H. et al. Helicobacter species in the atherosclerotic plaques of patients with coronary artery disease. Cardiovasc Pathol 2012; 21: 307-311.

The authors declare that there are no conflicts of interest present.