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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2016-9-124-129</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-1395</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Практика</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Practice</subject></subj-group></article-categories><title-group><article-title>Применение адеметионина в терапии хронических заболеваний печени</article-title><trans-title-group xml:lang="en"><trans-title>ADEMETIONINE THERAPY IN CHRONIC LIVER DISEASES</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ТОПЧИЙ</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>TOPCHIY</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>Cand. Med. Sc.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ТОПОРКОВ</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>TOPORKOV</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>Cand. Med. Sc.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>КУЗЕНКОВА</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>KUZENKOVA</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет дружбы народов, Москва; Ассоциация врачей общей практики (семейных врачей) РФ; Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples’ Friendship University of Russia; Association of General Practitioners (Family Practitioners) of the Russian Federation; Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Ассоциация врачей общей практики (семейных врачей) РФ; Первый Московский государственный медицинский университет им. И.М. Сеченова; Городская поликлиника №68 Департамента здравоохранения г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Association of General Practitioners (Family Practitioners) of the Russian Federation; Sechenov First Moscow State Medical University; City Outpatient Clinic No 68 of the Department of Public Health, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Российский университет дружбы народов, Москва; Городская поликлиника №68 Департамента здравоохранения г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples’ Friendship University of Russia; City Outpatient Clinic No 68 of the Department of Public Health, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>9</issue><fpage>124</fpage><lpage>129</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; ТОПЧИЙ Н.В., ТОПОРКОВ А.С., КУЗЕНКОВА Н.Н., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">ТОПЧИЙ Н.В., ТОПОРКОВ А.С., КУЗЕНКОВА Н.Н.</copyright-holder><copyright-holder xml:lang="en">TOPCHIY N.V., TOPORKOV A.S., KUZENKOVA N.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/1395">https://www.med-sovet.pro/jour/article/view/1395</self-uri><abstract><p>Лекарственно-индуцированные и алкогольные поражения занимают видное место среди хронических заболеваний печени. В течение последних 10 лет в России для их лечения применяются препараты адеметионина, оказывающие антиоксидантное и детоксицирующее действие, нормализующие проницаемость клеточных мембран, ускоряющие регенерацию клеток печени и замедляющие развитие фиброза. Согласно результатам многочисленных исследований, их применение приводит к улучшению белково-синтетической функции печени, уменьшению выраженности нарушений липидного обмена, положительной динамике биохимических показателей сыворотки крови (ЩФ, ГГТП, АЛТ, АСТ, билирубина), а также к регрессу клинических проявлений астено-вегетативного и диспептического синдромов при хорошей переносимости препарата [15, 17, 18].</p></abstract><trans-abstract xml:lang="en"><p>Drug- and alcohol-induced liver injuries are the most common reason for the chronic liver diseases. For the past 10years, in Russia ademetionine products have been used in treatment of such diseases to provide detoxification and antioxidant effects, normalize the permeability of the cell membranes, accelerate regeneration of liver cells and slow down the development of fibrosis. The numerous studies showed that the use of ademetionine improves a protein synthesis in the liver, reduces the severity of lipid exchange violations, contributes to positive dynamics of serum biochemical parameters (ALP, GGTP, ALT, AST, bilirubin) and regresses clinical manifestations of the astenovegetative and dyspeptic syndromes, while tolerability of ademetionine is favorable [15, 17, 18].</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лекарственно-индуцированные поражения печени</kwd><kwd>гепатотоксичность</kwd><kwd>адеметионин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>drug-induced liver injury</kwd><kwd>hepatotoxicity</kwd><kwd>ademetionine</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Абдурахманов Д.Т., Моисеев С.В. Лекарственные поражения печени. Фарматека. 2011, 17: 67-73. / Abdurakhmanov D.T., Moiseyev S.V. Drug-induced liver injuries. 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