medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2016-10-66-72medsovet-1407Research ArticleОнкологияOncologyПервый клинический опыт применения афатиниба в РоссииTHE FIRST CLINICAL EXPERIENCE WITH AFATINIB IN RUSSIAN FEDERATIONЛАКТИОНОВК. К.LAKTIONOVК. К.

д.м.н.

Москва

MD

ПЕРЕГУДОВАМ. В.PEREGUDOVAМ. V.

к.м.н

Москва

PhD in medicine

БРЕДЕРВ. В.BREDERV. V.

к.м.н

Москва

PhD in medicine

РЕУТОВАЕ. В.REUTOVAE. V.

к.м.н

Москва

PhD in medicine

ПЕРЕГУДОВД. А.PEREGUDOVD. A.

Москва

АРДЗИНБАМ. С.ARDZINBAM. S.

к.м.н.

Москва

PhD in medicine

ЧЕРНЕНКОП. А.CHERNENKOP. A.

к.м.н.

Москва

PhD in medicine

МАРИНОВД. Т.MARINOVD. T.

Москва

Российский онкологический научный центр им. Н.Н. Блохина Минздрава РоссииРоссияFSBSI «Russian Cancer Research Center n.a. N.N. Blokhin»Russian Federation2016301220160106672Copyright © ЛАКТИОНОВ К.К., ПЕРЕГУДОВА М.В., БРЕДЕР В.В., РЕУТОВА Е.В., ПЕРЕГУДОВ Д.А., АРДЗИНБА М.С., ЧЕРНЕНКО П.А., МАРИНОВ Д.Т., 20162016ЛАКТИОНОВ К.К., ПЕРЕГУДОВА М.В., БРЕДЕР В.В., РЕУТОВА Е.В., ПЕРЕГУДОВ Д.А., АРДЗИНБА М.С., ЧЕРНЕНКО П.А., МАРИНОВ Д.Т.LAKTIONOV К.К., PEREGUDOVA М.V., BREDER V.V., REUTOVA E.V., PEREGUDOV D.A., ARDZINBA M.S., CHERNENKO P.A., MARINOV D.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/1407

Результаты рандомизированных клинических исследований доказали преимущество неселективного ингибитора тирозинкиназы гена EGFR 2-го поколения афатиниба по сравнению с платиносодержащей химиотерапией у EGFR-позитивных больных аденокарциномой легкого как в первой, так и во второй линиях лечения. Показано достоверное улучшение выживаемости без прогрессирования (ВБП) в сравнении с платиносодержащей терапией и гефитинибом в 1-й линии лечения. Преимущество в общей выживаемости (ОВ) продемонстрировано в подгруппе больных с Del19 в крупных рандомизированных исследованиях. По данным ФГБУ «РОНЦ им. Н.Н. Блохина», объективный эффект (ОЭ) терапии афатинибом составил 62,7% при контроле роста опухоли 94,1%. Медиана ВБП – 18,0 мес. Наиболее частыми нежелательными явлениями являлись сыпь, паронихии и диарея, требующие редукции дозы препарата до 30 и 20 мг/сут у 34,5 и 16,4% пациентов соответственно. В целом отмечен благоприятный токсический профиль и улучшение качества жизни больных.

Randomized clinical trials results have shown the advantage of non-selective EGFR tyrosine kinase inhibitor 2nd generation – afatinib compared with platinum-based chemotherapy in adenocarcinoma EGFR-positive patients in both the first and second-line of treatment. Shown significant improvement in PFS compared with standard platinum contain regimen and gefitinib in the first line of treatment. Also afatinib demonstrated the efficacy in the second line of treatment of squamous cell carcinoma of lung. The advantage of OS demonstrated in the subgroup of patients with Del19 in the global randomized clinical trials. According to the local experience FSBSI «Russian Cancer Research Center n.a. N.N.Blokhin» ORR afatinib therapy was 62.7% in the tumor growth control 94.1%. Median PFS – 18.0 months. The most common adverse events observed a rash, paronychia, and diarrhea requiring dose reduction of up to 30 and 20 mg / day, 34.5% and 16.4% of patients, espectively. On the whole, marked by a favorable toxicity profile and improve the quality of patients life.

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The authors declare that there are no conflicts of interest present.