medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2016-10-84-92medsovet-1409Research ArticleОнкологияOncologyИпилимумаб в лечении метастатической меланомыIPILIMUMAB IN THERAPY OF METASTATIC MELANOMAСАМОЙЛЕНКОИ. В.SAMOILENKOI. V.

к.м.н.

Москва

PhD in medicine

Moscow

ХАРКЕВИЧГ. Ю.KHARKEVICHG. Y.

к.м.н.

Москва

PhD in medicine

Moscow

ДЕМИДОВЛ. В.DEMIDOVL. V.

д.м.н., профессор

Москва

MD, Prof

Moscow

Российский онкологический научный центр им. Н.Н. БлохинаРоссияBlokhin Russian Oncologic Scientific CenterRussian Federation2016301220160108492Copyright © САМОЙЛЕНКО И.В., ХАРКЕВИЧ Г.Ю., ДЕМИДОВ Л.В., 20162016САМОЙЛЕНКО И.В., ХАРКЕВИЧ Г.Ю., ДЕМИДОВ Л.В.SAMOILENKO I.V., KHARKEVICH G.Y., DEMIDOV L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/1409

Метастатическая меланома остается заболеванием, трудно поддающимся лечению. Большой прогресс в лечении пациентов с метастатической меланомой был достигнут за последние пять лет. Принципиально новым направлением в лекарственной терапии опухолей стала таргетная иммунотерапия – избирательное воздействие на сигнальные молекулы лимфоцитов. Ипилимумаб – первый препарат данного класса, который продемонстрировал клиническую эффективность у больных метастатической меланомой. В данной статье приводится обзор наиболее актуальных данных международных исследований и собственный клинический опыт применения ипилимумаба у больных метастатической меланомой.

Metastatic melanoma remains a refractory disease. Great progress in therapy of metastatic melanoma patients has been made in the recent five years. Targeted immunotherapy – a selective effect on lymphocytes signal molecules - became a principally new trend in the drug therapy of tumors. Ipilimumab is the first drug of this class that demonstrated clinical effectiveness in metastatic melanoma patients. This article deals with a review of the latest data of internal studies and own clinical experience of ipilimumab application in metastatic melanoma patients.

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The authors declare that there are no conflicts of interest present.