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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2016-10-98-102</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-1411</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КАРДИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CARDIOLOGY</subject></subj-group></article-categories><title-group><article-title>Антитромбоцитарные средства при остром коронарном синдроме: прямое сравнение геморрагической безопасности блокаторов P2Y12-рецепторов тромбоцитов тикагрелора и клопидогрела (по данным исследования PLATO)</article-title><trans-title-group xml:lang="en"><trans-title>ANTI-THROMBOCYTIC DRUGS FOR ACUTE CORONARY SYNDROME: DIRECT COMPARISON OF HEMORRHAGIC SAFETY THROMBOCYTE P2Y12-RECEPTOR BLOCKERS TICAGRELOR AND CLOPIDROGEL (BASED ON PLATO STUDY RESULTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>АВЕРКОВ</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>AVERKOV</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н.</p><p>Москва</p></bio><bio xml:lang="en"><p>MD</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Городская клиническая больница №15 им. О.М. Филатова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Filatov Municipal Clinical Hospital No.15</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>10</issue><fpage>98</fpage><lpage>102</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; АВЕРКОВ О.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">АВЕРКОВ О.В.</copyright-holder><copyright-holder xml:lang="en">AVERKOV O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/1411">https://www.med-sovet.pro/jour/article/view/1411</self-uri><abstract><p>Двойная антитромбоцитарная терапия (ДАТТ), включающая сочетание ацетилсалициловой кислоты и одного из блокаторов P2Y12-рецепторов тромбоцитов, считается обязательным элементом лечения острого коронарного синдрома (ОКС) [1–5]. Расширение арсенала антитромбоцитарных средств с активным внедрением тикагрелора и празугрела привело к появлению вопросов у кардиологов, оказывающих помощь больным с острым коронарным синдромом. Несмотря на декларированное в рекомендациях приоритетное использование этих средств вместо клопидогрела, врачи практически ежедневно сталкиваются с необходимостью выбора оптимального блокатора P2Y12, оценивая ожидаемые индивидуальные эффективность, геморрагическую безопасность и стоимость достаточно длительного лечения. Для врачей, практикующих на территории РФ, в отличие от врачей в других странах, проблема выбора блокатора P2Y12 менее масштабна, т. к. выбирать приходится только между тикагрелором и клопидогрелом (празугрел в РФ не применяется).</p></abstract><trans-abstract xml:lang="en"><p>Double anti-platelet therapy (DAPT) comprising a combination of acetylsalicylic acid and one of the thrombocyte P2Y12-receptor blockers is considered an obligatory element of the acute coronary syndrome (ACS) therapy [1–5]. Enlargement of the antiplatelet drugs range with active implementation of ticagrelor and prasugrel led to questions in cardiologists who render medical aid to acute coronary syndrome patients. Despite the priority use of these drugs declared in recommendations instead of clopidrogel doctors practically daily face a necessity to choose the optimal P2Y12 blocking agent assessing the expected individual effectiveness, hemorrhagic safety and cost of the rather long-acting therapy. For doctors practicing in the territory of the RF as opposed to doctors in other countries the problem of the P2Y12 blocking agent is less large-scale as they have to choose only between ticagrelor and clopidrogel (prasugrel is not applied in the RF).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый коронарный синдром</kwd><kwd>антитромбоцитарные средства</kwd><kwd>блокаторы P2Y12</kwd><kwd>тикагрелор</kwd><kwd>клопидогрел</kwd><kwd>исследование PLATO</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute coronary syndrome</kwd><kwd>anti-platelet drugs</kwd><kwd>P2Y12 blockers</kwd><kwd>ticagrelor</kwd><kwd>clopidrogel</kwd><kwd>PLATO study</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Amsterdam EA, Wenger NK, Brindis RG, Casey DE Jr et al. 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