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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2016-12-95-97</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-1439</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Контрацепция</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Contraception</subject></subj-group></article-categories><title-group><article-title>КОНТРАЦЕПЦИЯ С ДРОСПИРЕНОНОМ: ВЛИЯНИЕ НА МАССУ ТЕЛА И НЕКОТОРЫЕ ПОКАЗАТЕЛИ МЕТАБОЛИЗМА ЛИПИДОВ</article-title><trans-title-group xml:lang="en"><trans-title>CONTRACEPTION WITH DROSPIRENONE:  EFFECT ON THE BODY WEIGHT AND SOME LIPID METABOLISM INDICATORS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сметник</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Smetnik</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук</p></bio><bio xml:lang="en"><p>PhD in medicine</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Научный центр акушерства, гинекологии и перинатологии имени академика  В.И. Кулакова, Москва<country>Россия</country></aff><aff xml:lang="en">Kulakov Scientific Center of Obstetrics, Gynecology and Perinatology, Moscow<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>12</issue><fpage>95</fpage><lpage>97</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сметник А.А., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Сметник А.А.</copyright-holder><copyright-holder xml:lang="en">Smetnik A.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/1439">https://www.med-sovet.pro/jour/article/view/1439</self-uri><abstract><p>Комбинированный оральный контрацептив, содержащий 20 мкг этинилэстрадиола  и 3 мг дроспиренона, является эффективным методом  контрацепции,  обладающим оптимальным  укороченным безгормональным интервалом и хорошей переносимостью, обусловленной положительным влиянием на массу тела, метаболизм липидов, общее состояние и симптомы, связанные с задержкой жидкости и гиперандрогенизмом. Полученные в исследованиях in vitro и in vivo данные о роли дроспиренона в блокировании дифференцировки адипоцитов и аккумуляции триглицеридов,  а также регуляции ремоделирования белого жира обосновывают возможные эффекты данного препарата на предотвращение негативных метаболических последствий дисфункции адипоцитов. Результаты клинических исследований указывают на снижение массы тела и положительный эффект на липидный профиль без значимого влияния на чувствительность к инсулину, что приводит к высокой степени удовлетворенности женщин данным видом контрацепции.</p></abstract><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>комбинированный оральный контрацептив</kwd><kwd>дроспиренон</kwd><kwd>минералокортикоидный рецептор</kwd><kwd>масса тела</kwd><kwd>адипоциты</kwd><kwd>липиды</kwd></kwd-group><kwd-group xml:lang="en"><kwd>combined oral contraceptive</kwd><kwd>drospirenone</kwd><kwd>mineral-corticoid receptor</kwd><kwd>body weight</kwd><kwd>adipocytes</kwd><kwd>lipids</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Petitti DB. Clinical practice. Combination estrogen-progestin oral contraceptives. 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