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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2016-18-64-68</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-1487</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНО</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACTUAL</subject></subj-group></article-categories><title-group><article-title>Современные подходы к лечению аллергического риносинусита</article-title><trans-title-group xml:lang="en"><trans-title>Modern approaches to therapy of allergic rhinosinusitis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кочетков</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kochetkov</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>PhD in medicine</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Свистушкин</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Svistushkin</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><bio xml:lang="en"><p>MD, Prof.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мейтель</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Meytel</surname><given-names>I. Y.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>18</issue><fpage>64</fpage><lpage>68</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кочетков П.А., Свистушкин В.М., Мейтель И.Ю., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Кочетков П.А., Свистушкин В.М., Мейтель И.Ю.</copyright-holder><copyright-holder xml:lang="en">Kochetkov P.A., Svistushkin V.M., Meytel I.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/1487">https://www.med-sovet.pro/jour/article/view/1487</self-uri><abstract><p>Проблема лечения аллергического риносинусита чрезвычайно актуальна на сегодняшний день. Это связано, с одной стороны, с интенсивным ростом заболеваемости, с другой – с утяжелением течения аллергического процесса, присоединением инфекционных осложнений, развитием полисенсибилизации. Подход к диагностике данного заболевания должен быть последовательным и комплексным. Тщательный анализ клинических проявлений и рациональное применение диагностических тестов чрезвычайно важны для правильной постановки диагноза. Аллергический ринит является IgE-опосредованным первично хроническим воспалительным заболеванием слизистой оболочки полости носа. Основой назначения рациональной терапии данного заболевания является точное понимание патогенетических механизмов его развития. Хирургическое лечение показано таким пациентам в большом проценте случаев, однако оно не играет патогенетической роли. </p></abstract><trans-abstract xml:lang="en"><p>The issue of allergic rhinosinusitis therapy is extremely urgent as of today. This is related, on the one hand, to the intense growth of the disease incidence, on the other hand, with aggravation of the allergic process course, addition of infectious complications, development of polysensitization. The approach to diagnostics of this disease must be consistent and complex. The accurate analysis of clinical manifestations and rational use of diagnostics tests are extremely important for the correct diagnosing. Allergic rhinitis is IgE-mediated primary chronic inflammatory disease of the mucous tunic of the nasal cavity. The basis of prescription of the rational therapy of this disease is clear understanding of pathogenic mechanisms of its development. Surgical therapy is indicated for these patients in the majority of cases, but it doesn’t have any pathogenic role. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>аллергический риносинусит</kwd><kwd>IgE-опосредованная гиперэргическая иммунная реакция</kwd><kwd>гиперсенсибилизация</kwd><kwd>антигистаминные препараты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>allergic rhinosinusitis</kwd><kwd>IgE-mediated hyperergic immune reaction</kwd><kwd>hypersensitization</kwd><kwd>antihistamine drugs</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bousquet J. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy, 2008 Apr, 63(Suppl 86): 8-160.</mixed-citation><mixed-citation xml:lang="en">Bousquet J. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy, 2008 Apr, 63(Suppl 86): 8-160.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Крюков А.И., Гурбанов Ф.А. Патогенетическая терапия аллергического риносинусита на современном этапе. Российская оториноларингология, 2010, 5(48): 25-29.</mixed-citation><mixed-citation xml:lang="en">Крюков А.И., Гурбанов Ф.А. Патогенетическая терапия аллергического риносинусита на современном этапе. Российская оториноларингология, 2010, 5(48): 25-29.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Лопатин А.С., Гамов В.П. Острый и хронический риносинусит: этиология, патогенез, клиника, диагностика и принципы лечения: Учебное пособие для системы послевузовского проф. образования врачей. М.: МИА, 2011. 72 с.</mixed-citation><mixed-citation xml:lang="en">Лопатин А.С., Гамов В.П. Острый и хронический риносинусит: этиология, патогенез, клиника, диагностика и принципы лечения: Учебное пособие для системы послевузовского проф. образования врачей. М.: МИА, 2011. 72 с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Никифорова Г.Н., Волкова К.Б., Свистушкин В.М. Место и значение современных антигистаминных препаратов в лечении аллергического ринита. РМЖ, 2015, 23: 1395-1398.</mixed-citation><mixed-citation xml:lang="en">Никифорова Г.Н., Волкова К.Б., Свистушкин В.М. Место и значение современных антигистаминных препаратов в лечении аллергического ринита. РМЖ, 2015, 23: 1395-1398.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Лопатин А.С. Ринит: руководство для врачей. М.: ГЭОТАР-Медиа, 2010. 417 с.</mixed-citation><mixed-citation xml:lang="en">Лопатин А.С. Ринит: руководство для врачей. М.: ГЭОТАР-Медиа, 2010. 417 с.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Arbes SJ Jr, Gergen PJ, Elliott L, Zeldin DC. Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. J Allergy Clin Immunol, 2005, 116: 377-383.</mixed-citation><mixed-citation xml:lang="en">Arbes SJ Jr, Gergen PJ, Elliott L, Zeldin DC. Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. J Allergy Clin Immunol, 2005, 116: 377-383.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Jones NS, Smith PA, Carney AS, Davis A. The prevalence of allergic rhinitis and nasal symptoms in Not- tingham. Clin Otolaryngol, 1998, 23: 547-554.</mixed-citation><mixed-citation xml:lang="en">Jones NS, Smith PA, Carney AS, Davis A. The prevalence of allergic rhinitis and nasal symptoms in Not- tingham. Clin Otolaryngol, 1998, 23: 547-554.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Magnan A, Romanet S, Vervloet D. Rhinitis, nasosinusalpoliposis and asthma: clinical aspects. The Nose and Lung Diseases. Ed. by B Wallaert, P Chanez, P Godard. Eur. Resp. Monograph. 2001: 101-115.</mixed-citation><mixed-citation xml:lang="en">Magnan A, Romanet S, Vervloet D. Rhinitis, nasosinusalpoliposis and asthma: clinical aspects. The Nose and Lung Diseases. Ed. by B Wallaert, P Chanez, P Godard. Eur. Resp. Monograph. 2001: 101-115.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">ARIA. Аллергический ринит и его влияние на бронхиальную астму. Аллергология. Приложение, 2001, 3: 43-56.</mixed-citation><mixed-citation xml:lang="en">ARIA. Аллергический ринит и его влияние на бронхиальную астму. Аллергология. Приложение, 2001, 3: 43-56.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Izquierdo-Domínguez A, Valero AL, Mullol J. Comparative analysis of allergic rhinitis in children and adults. Curr. Allergy Asthma Rep, 2013 Apr, 13(2): 142-141.</mixed-citation><mixed-citation xml:lang="en">Izquierdo-Domínguez A, Valero AL, Mullol J. Comparative analysis of allergic rhinitis in children and adults. Curr. Allergy Asthma Rep, 2013 Apr, 13(2): 142-141.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kimihiro Okubo et al. Japanese Guideline for Allergic Rhinitis. Allergology International, 2011, 60: 171-189.</mixed-citation><mixed-citation xml:lang="en">Kimihiro Okubo et al. Japanese Guideline for Allergic Rhinitis. Allergology International, 2011, 60: 171-189.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Татаурщикова Н.С. Дезлоратадин – современное эффективное средство лечения аллергического ринита. Фарматека, 2013, 10: 66-68.</mixed-citation><mixed-citation xml:lang="en">Татаурщикова Н.С. Дезлоратадин – современное эффективное средство лечения аллергического ринита. Фарматека, 2013, 10: 66-68.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Molimard M, Diquet B, Benedetti MS. Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in hu mans. Fundam Clin Pharmacol, 2004, 18(4): 399-411.</mixed-citation><mixed-citation xml:lang="en">Molimard M, Diquet B, Benedetti MS. Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in hu mans. Fundam Clin Pharmacol, 2004, 18(4): 399-411.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Limon L, Kockler DR. Desloratadine: a nonsedating antihistamine. Ann Pharmacother, 2003, 37(2): 237-246.</mixed-citation><mixed-citation xml:lang="en">Limon L, Kockler DR. Desloratadine: a nonsedating antihistamine. Ann Pharmacother, 2003, 37(2): 237-246.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Wu RL et al. Desloratadine inhibits constitutive and histamine-stimulated nuclear factor-kappaB activity consistent with inverse agonism at the histamine H1 Receptor. Int Arch Allergy Immunol, 2004, 135(4): 313-318.</mixed-citation><mixed-citation xml:lang="en">Wu RL et al. Desloratadine inhibits constitutive and histamine-stimulated nuclear factor-kappaB activity consistent with inverse agonism at the histamine H1 Receptor. Int Arch Allergy Immunol, 2004, 135(4): 313-318.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Genovese A et al. Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human Fc epsilon RI+ cells. Clin Exp Allergy, 1997, 27(5): 559-567.</mixed-citation><mixed-citation xml:lang="en">Genovese A et al. Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human Fc epsilon RI+ cells. Clin Exp Allergy, 1997, 27(5): 559-567.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ring J. et al. Once-daily desloratadine improves the signs and symptoms of chronic idiopathic urticaria: a randomized, double-blind, placebocontrolled study. Int J Dermatol, 2001, 40(1): 72-76.</mixed-citation><mixed-citation xml:lang="en">Ring J. et al. Once-daily desloratadine improves the signs and symptoms of chronic idiopathic urticaria: a randomized, double-blind, placebocontrolled study. Int J Dermatol, 2001, 40(1): 72-76.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Bachert C, Maurer M. Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria results of four postmarketing surveillance studies. Clin Drug Investig, 2010, 30(2): 109-122.</mixed-citation><mixed-citation xml:lang="en">Bachert C, Maurer M. Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria results of four postmarketing surveillance studies. Clin Drug Investig, 2010, 30(2): 109-122.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
