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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2016-11-92-99</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-1548</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СПАСТИЧЕСКИЕ РАССТРОЙСТВА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SPASTIC DISORDERS</subject></subj-group></article-categories><title-group><article-title>КОМПЛЕКСНАЯ РЕАБИЛИТАЦИЯ ПАЦИЕНТОВ С ПОСТИНСУЛЬТНОЙ СПАСТИЧНОСТЬЮ НИЖНЕЙ КОНЕЧНОСТИ ЭФФЕКТИВНОСТЬ ПРИМЕНЕНИЯ БОТУЛОТОКСИНА (ОНАБОТУЛОТОКСИН А*)</article-title><trans-title-group xml:lang="en"><trans-title>COMPLEX REHABILITATION PATIENTS WITH POST-STROKE SPASTICITY OF THE LOWER LIMB: THE EFFICACY OF BOTULINUM TOXIN (ONABOTULINUMTOXIN A)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>КОСТЕНКО</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>KOSTENKO</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н.</p></bio><bio xml:lang="en"><p>MD</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ПЕТРОВА</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>PETROVA</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>PhD in medicine</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва&#13;
Московский научно-практический центр медицинской реабилитации, восстановительной и спортивной медицины<country>Россия</country></aff><aff xml:lang="en">Pirogov Russian National Research Medical University, Moscow, Pirogow City Clinical Hospital;&#13;
Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine of Moscow Healthcare Department<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Московский научно-практический центр медицинской реабилитации, восстановительной и спортивной медицины<country>Россия</country></aff><aff xml:lang="en">Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine of Moscow Healthcare Department<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>11</issue><fpage>92</fpage><lpage>99</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; КОСТЕНКО Е.В., ПЕТРОВА Л.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">КОСТЕНКО Е.В., ПЕТРОВА Л.В.</copyright-holder><copyright-holder xml:lang="en">KOSTENKO E.V., PETROVA L.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/1548">https://www.med-sovet.pro/jour/article/view/1548</self-uri><abstract><p>Цель исследования – изучение эффективности применения препарата онаботулотоксин А (Ботокс®) в комплексной реабилитации больных со спастичностью ноги в раннем восстановительном периоде инсульта. Материал и методы: группу наблюдения составили 31 пациент в раннем восстановительном периоде инсульта с эквиноварусной деформацией стопы с уровнем спастичности не менее 3 баллов. Все пациенты получали в составе комплексной реабилитационной программы инъекции онаботулотоксина А в общей дозе 300 ЕД. Оценивали динамику неврологического статуса, спастичности, болевого синдрома, функцию ходьбы и повседневную активность. Результаты и заключение: доказана высокая эффективность Ботокса в виде уменьшения выраженности спастичности, дискомфорта в голени и стопе, облегчения возможности самостоятельного передвижения больного, увеличения скорости ходьбы.</p></abstract><trans-abstract xml:lang="en"><p>The purpose of the study was to examine the effectiveness of the drug of onabotulinumtoxin A (Botox) in complex rehabilitation of patients with post-stroke spasticity of the legs in the early rehabilitation period of stroke. Materials and methods. The study group was comprised 31 patients in the early recovery period after stroke with the presence of equino-varus deformity of the foot with the level of spasticity grade of 3 or more (MAS). All patients received as part of a comprehensive rehabilitation program injections onabotulinumtoxin a (Botox) in a total dose 300 ED. In the process of treatment was evaluated dynamics of neurological status, spasticity, pain, function of walking and everyday activity. Results and conclusion. Proven high efficacy of botulinum neurotoxin type A: reduces the severity of spasticity, the severity of the discomfort in the leg and foot; facilitated the possibility of independent movement of the patient, increases walking speed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>реабилитация</kwd><kwd>постинсультная спастичность</kwd><kwd>инсульт</kwd><kwd>эквиноварусная деформация стопы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rehabilitation</kwd><kwd>post-stroke spasticity</kwd><kwd>stroke</kwd><kwd>equino-varus foot deformity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wissel J, Manack A , Brainin M. Toward an epidemiology of poststroke spasticity. Neurology, 2013, 3(2): 13-19.</mixed-citation><mixed-citation xml:lang="en">Wissel J, Manack A , Brainin M. Toward an epidemiology of poststroke spasticity. Neurology, 2013, 3(2): 13-19.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Феррахов А.З., Хабиров Ф.А., Ибрагимов М.Ф., Хай буллин Т.И., Гранатов Е.В. Комплексная реабилитация больных, перенесших инсульт, на этапах «стационар – реабилитационный центр – поликлиника». Неврологический вестник, 2012, 44(4): 3-8. [Ferrakhov A.Z., Khabirov F.A., Ibragimov M.F., Khaibullin T.I., Granatov E.V. Complex rehabilitation of patients who suffered from a str oke, at the stages “inpatient department – rehabilitation center – polyclinic”. Nevrologicheskiy Vestnik, 2012, 44 (4): 3-8].</mixed-citation><mixed-citation xml:lang="en">Феррахов А.З., Хабиров Ф.А., Ибрагимов М.Ф., Хай буллин Т.И., Гранатов Е.В. Комплексная реабилитация больных, перенесших инсульт, на этапах «стационар – реабилитационный центр – поликлиника». Неврологический вестник, 2012, 44(4): 3-8. [Ferrakhov A.Z., Khabirov F.A., Ibragimov M.F., Khaibullin T.I., Granatov E.V. Complex rehabilitation of patients who suffered from a str oke, at the stages “inpatient department – rehabilitation center – polyclinic”. Nevrologicheskiy Vestnik, 2012, 44 (4): 3-8].</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ward AB, Aguilar M, De Beyl Z, Gedin S, Kanovsky P, Molteni F, et al. Use of botulinumtoxin type A in management of adult spasticity-a European consensus st atement. J Rehabil Med, 2003, 35: 98-99.</mixed-citation><mixed-citation xml:lang="en">Ward AB, Aguilar M, De Beyl Z, Gedin S, Kanovsky P, Molteni F, et al. Use of botulinumtoxin type A in management of adult spasticity-a European consensus st atement. J Rehabil Med, 2003, 35: 98-99.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов В .А. Постинсультная спастичность и ее лечение. РМЖ, 2006, 1, 9(261): 689-693.</mixed-citation><mixed-citation xml:lang="en">Парфенов В .А. Постинсультная спастичность и ее лечение. РМЖ, 2006, 1, 9(261): 689-693.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Urban P, Wolf T, Uebele M. Occurence and clinical predictors of spasticity after ischemic stroke. Stroke, 2010, 41(9): 2016-2020.</mixed-citation><mixed-citation xml:lang="en">Urban P, Wolf T, Uebele M. Occurence and clinical predictors of spasticity after ischemic stroke. Stroke, 2010, 41(9): 2016-2020.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Picelli A, Tamburin S, Gajofatto F, Zanette G, Praitano M, Saltuari L et al. Association between Severe Upper Limb Spasticityand Brain Lesion Location in Stroke Patients. Biomed Research International, 2014, 1-6.</mixed-citation><mixed-citation xml:lang="en">Picelli A, Tamburin S, Gajofatto F, Zanette G, Praitano M, Saltuari L et al. Association between Severe Upper Limb Spasticityand Brain Lesion Location in Stroke Patients. Biomed Research International, 2014, 1-6.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Reichel G. Therapielietfa den Spastik. 3. Auflage-Bremen, UNI-MED, 2013: 190.</mixed-citation><mixed-citation xml:lang="en">Reichel G. Therapielietfa den Spastik. 3. Auflage-Bremen, UNI-MED, 2013: 190.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Watkins C, Leathley M, Gregson J, Moore A, Smith T, Sharma A. Prevalence of spasticity post stroke. Clinical Rehabil, 2002, 16: 515-552.</mixed-citation><mixed-citation xml:lang="en">Watkins C, Leathley M, Gregson J, Moore A, Smith T, Sharma A. Prevalence of spasticity post stroke. Clinical Rehabil, 2002, 16: 515-552.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lundström E, Smits A, Borg J, Terént A. C omment in Stroke, 2010, 41(7): e470, author reply e471. Stroke, 2010, 41(2): 201-202.</mixed-citation><mixed-citation xml:lang="en">Lundström E, Smits A, Borg J, Terént A. C omment in Stroke, 2010, 41(7): e470, author reply e471. Stroke, 2010, 41(2): 201-202.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Батышева Т.Т., Бойко А.Н., Костенко Е.В. Методологические основы лечения спастичности. Медико-социальные аспекты лечения спастичн ости в практике врача-невролога. Материалы научно-практической конференции. М., 2010: 6-9. [Batysheva T.T., Boyko A.N., Kostenko E.V. Methodological fundamentals of spacticity therapy. Medical and social aspects of spasticity therapy in the practice of a neurologist. Materials of scientific and practical conference. M., 2010; 6-9].</mixed-citation><mixed-citation xml:lang="en">Батышева Т.Т., Бойко А.Н., Костенко Е.В. Методологические основы лечения спастичности. Медико-социальные аспекты лечения спастичн ости в практике врача-невролога. Материалы научно-практической конференции. М., 2010: 6-9. [Batysheva T.T., Boyko A.N., Kostenko E.V. Methodological fundamentals of spacticity therapy. Medical and social aspects of spasticity therapy in the practice of a neurologist. Materials of scientific and practical conference. M., 2010; 6-9].</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Гусев Е.И., Гехт А.Б., Гаптов В.Б., Тихопой Е.В. Реабилитация в неврологии. М., 2000: 52. [ Gusev E.I., Gekht A.B., Gaptov V.B., Tikhopoy E.V. Rehabilitation in neurology. M., 2000: 52].</mixed-citation><mixed-citation xml:lang="en">Гусев Е.И., Гехт А.Б., Гаптов В.Б., Тихопой Е.В. Реабилитация в неврологии. М., 2000: 52. [ Gusev E.I., Gekht A.B., Gaptov V.B., Tikhopoy E.V. Rehabilitation in neurology. M., 2000: 52].</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьева О.В. Нарушение мышечного тонуса в постинсультном периоде: вопросы терапии. Consilium Medicum, 2004, 6: 12-18. [ Vorobieva O.V. Disturbance of muscular tonus in poststroke period: issues of therapy. Consilium Medicum, 2004, 6: 12-18].</mixed-citation><mixed-citation xml:lang="en">Воробьева О.В. Нарушение мышечного тонуса в постинсультном периоде: вопросы терапии. Consilium Medicum, 2004, 6: 12-18. [ Vorobieva O.V. Disturbance of muscular tonus in poststroke period: issues of therapy. Consilium Medicum, 2004, 6: 12-18].</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Хатькова С.Е. Лечение спастичности после инсульта. Неврология, нейропсихиатрия, психосоматика, 2010, 3: 76-80. [Khatkova S.E. Treatment of spasticity after stroke. Nevrologia, neuropsikhiatria, psikhosomatika, 2010, 3: 76-80].</mixed-citation><mixed-citation xml:lang="en">Хатькова С.Е. Лечение спастичности после инсульта. Неврология, нейропсихиатрия, психосоматика, 2010, 3: 76-80. [Khatkova S.E. Treatment of spasticity after stroke. Nevrologia, neuropsikhiatria, psikhosomatika, 2010, 3: 76-80].</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Pathak M, Nguyen H, Graham H, Moore A. Management of spasticity in adults: practical application of botulinumtoxin. Eur J. Neurol, 2006, 13: 42-50.</mixed-citation><mixed-citation xml:lang="en">Pathak M, Nguyen H, Graham H, Moore A. Management of spasticity in adults: practical application of botulinumtoxin. Eur J. Neurol, 2006, 13: 42-50.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Gracies JM., Singer BJ, Dunne JW. The role of botulinum toxin injections in the management of muscle overactivity of the lower limb. Disabil Rehabil, 2007, 29(23): 1789-1803.</mixed-citation><mixed-citation xml:lang="en">Gracies JM., Singer BJ, Dunne JW. The role of botulinum toxin injections in the management of muscle overactivity of the lower limb. Disabil Rehabil, 2007, 29(23): 1789-1803.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kirazli Y, On A.Y, Kismali B, Aksit R. Comparison of phenol block and botulinum toxin type A in the treatment of spastic foot after stroke: a randomized, double-blind trial. Am J Phys Med Rehabil, 1998, 77: 510-515.</mixed-citation><mixed-citation xml:lang="en">Kirazli Y, On A.Y, Kismali B, Aksit R. Comparison of phenol block and botulinum toxin type A in the treatment of spastic foot after stroke: a randomized, double-blind trial. Am J Phys Med Rehabil, 1998, 77: 510-515.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Suputtitada A, Suwanwela N. The lowest effective dose of botulinum A toxin in adult patients with upper limb spasticit y. Disabil Rehabil, 2005, 27: 176-184.</mixed-citation><mixed-citation xml:lang="en">Suputtitada A, Suwanwela N. The lowest effective dose of botulinum A toxin in adult patients with upper limb spasticit y. Disabil Rehabil, 2005, 27: 176-184.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Малахов В.А. Мышечная спастичность при органических заболеваниях нервной системы и ее коррекция. Международный неврологический журнал, 2010, 5(35): 34-39. [Malakhov V.A. Muscular spasticity in organic diseases of the nervous system and its correction. Mezhdunarodny Nevrologichesky J ournal, 2010, 5 (35): 34-39].</mixed-citation><mixed-citation xml:lang="en">Малахов В.А. Мышечная спастичность при органических заболеваниях нервной системы и ее коррекция. Международный неврологический журнал, 2010, 5(35): 34-39. [Malakhov V.A. Muscular spasticity in organic diseases of the nervous system and its correction. Mezhdunarodny Nevrologichesky J ournal, 2010, 5 (35): 34-39].</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Dressler D, AdibSaberi F. Botulinumtoxin: mechanismsofaction. Eur Neurol, 2005, 53: 3-9.</mixed-citation><mixed-citation xml:lang="en">Dressler D, AdibSaberi F. Botulinumtoxin: mechanismsofaction. Eur Neurol, 2005, 53: 3-9.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Elia AE, Filippini G, Calandrella D, Albanese A. Botulinum neurotoxins for post-stroke spasticity in adults: a systematic review. MovDisord, 2009, 24(6): 801-812.</mixed-citation><mixed-citation xml:lang="en">Elia AE, Filippini G, Calandrella D, Albanese A. Botulinum neurotoxins for post-stroke spasticity in adults: a systematic review. MovDisord, 2009, 24(6): 801-812.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Gallichio JE Pharmacologic management of spasticity following stroke. Phys Ther, 2004, 84(10): 973-981.</mixed-citation><mixed-citation xml:lang="en">Gallichio JE Pharmacologic management of spasticity following stroke. Phys Ther, 2004, 84(10): 973-981.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Guidelines for the use of botulinum toxin (BTX) in the management of spasticity in adults. Clinical Effectiveness &amp; Evaluation, Unit. Royal College of Physicians, 2002, 17.</mixed-citation><mixed-citation xml:lang="en">Guidelines for the use of botulinum toxin (BTX) in the management of spasticity in adults. Clinical Effectiveness &amp; Evaluation, Unit. Royal College of Physicians, 2002, 17.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson C, Burridge J, Strike P, Wood D, Swain I. The effect of combined use of botulinum toxin type A and functional electric stimulation in the treatment of spastic drop foot after stroke: a preliminary investigation. Arch Phys Med Rehabil, 2004, 85: 9 02-909.</mixed-citation><mixed-citation xml:lang="en">Johnson C, Burridge J, Strike P, Wood D, Swain I. The effect of combined use of botulinum toxin type A and functional electric stimulation in the treatment of spastic drop foot after stroke: a preliminary investigation. Arch Phys Med Rehabil, 2004, 85: 9 02-909.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">O’Brien C. Treatment of spasticity with botulinum toxin. Clin J Pain, 2002, 18: 1 82-190.</mixed-citation><mixed-citation xml:lang="en">O’Brien C. Treatment of spasticity with botulinum toxin. Clin J Pain, 2002, 18: 1 82-190.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Cheung J, Rancourt А, Di Poce S, Levine А, Hoang J, Ismail F. Patient-Identified Factors That Influence Spasticity in People with Stroke and Multiple Scler osis Receiving Botulinum Toxin Injection Treatments. Physiother Can, 2015, 67(2): 157-166.</mixed-citation><mixed-citation xml:lang="en">Cheung J, Rancourt А, Di Poce S, Levine А, Hoang J, Ismail F. Patient-Identified Factors That Influence Spasticity in People with Stroke and Multiple Scler osis Receiving Botulinum Toxin Injection Treatments. Physiother Can, 2015, 67(2): 157-166.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Кадыков А.С.,Черникова Л.А., Шахпаронова Н.В. Реабилитация неврологических больных. М: МЕДпресс-информ, 2008: 560. [Kadykov A.S., Chernikova L.A., Shakhparanova N.V. Rehabilitaiton of neurologic patients. M: MEDpress-inform, 2008:560].</mixed-citation><mixed-citation xml:lang="en">Кадыков А.С.,Черникова Л.А., Шахпаронова Н.В. Реабилитация неврологических больных. М: МЕДпресс-информ, 2008: 560. [Kadykov A.S., Chernikova L.A., Shakhparanova N.V. Rehabilitaiton of neurologic patients. M: MEDpress-inform, 2008:560].</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Francis H, Wade D, Turner-Stokes L., Kingswell R, Dott C, Coxon E. Does reducing spasticity translate into functional benefit? An exploratory meta-analysis. J Neurol Neurosurg Psychiatry, 2004, 75: 1547-1551.</mixed-citation><mixed-citation xml:lang="en">Francis H, Wade D, Turner-Stokes L., Kingswell R, Dott C, Coxon E. Does reducing spasticity translate into functional benefit? An exploratory meta-analysis. J Neurol Neurosurg Psychiatry, 2004, 75: 1547-1551.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Turkel C, Bowen B, Liu J, Brin M. Pooled analysis of the safety of botulinum toxin type Ain the treatment of post-stroke spasticity. Arch Phys Med Rehabil, 2006, 87: 786-792.</mixed-citation><mixed-citation xml:lang="en">Turkel C, Bowen B, Liu J, Brin M. Pooled analysis of the safety of botulinum toxin type Ain the treatment of post-stroke spasticity. Arch Phys Med Rehabil, 2006, 87: 786-792.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Bakheit A, Fedorova N, Skoromets A, Timerbaeva S, Bhakta B, Coxon L. The beneficial antispasticity effect of botulinum toxin type A is maintained after repeated treatment cycles. J Neurol Neurosurg Psychiatry, 2004, 75: 1558-1561.</mixed-citation><mixed-citation xml:lang="en">Bakheit A, Fedorova N, Skoromets A, Timerbaeva S, Bhakta B, Coxon L. The beneficial antispasticity effect of botulinum toxin type A is maintained after repeated treatment cycles. J Neurol Neurosurg Psychiatry, 2004, 75: 1558-1561.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Brashear A, Gordon M, Elovic E, Kassicieh V, Marciniak C, Do M., Botox Post-Stroke Spasticity Study Group. Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after a stroke. N Engl J Med, 2002, 347: 395-400.</mixed-citation><mixed-citation xml:lang="en">Brashear A, Gordon M, Elovic E, Kassicieh V, Marciniak C, Do M., Botox Post-Stroke Spasticity Study Group. Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after a stroke. N Engl J Med, 2002, 347: 395-400.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Opheim А, Danielsson А, Alt Murphy М, Persson Н, Sunnerhagen К. Early prediction of longterm upper limb spasticity after stroke: Part of the SALGOT study. Neurology, 2015, 85(10): 873-880.</mixed-citation><mixed-citation xml:lang="en">Opheim А, Danielsson А, Alt Murphy М, Persson Н, Sunnerhagen К. Early prediction of longterm upper limb spasticity after stroke: Part of the SALGOT study. Neurology, 2015, 85(10): 873-880.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Burbaud P, Wiart L, Dubos J, Gaujard E, Debelleix X, Joseph P. A randomized, double blind, placebo controlled trial of botulinum toxin in the treatment of spastic foot in hemiparetic patients. J Neurol Neurosurg Psychiatry, 1996, 61: 265-269.</mixed-citation><mixed-citation xml:lang="en">Burbaud P, Wiart L, Dubos J, Gaujard E, Debelleix X, Joseph P. A randomized, double blind, placebo controlled trial of botulinum toxin in the treatment of spastic foot in hemiparetic patients. J Neurol Neurosurg Psychiatry, 1996, 61: 265-269.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Childers M, Brashear A, Jozefczyk P, Reding M, Alexander D, Good D. Dose-dependent response to intramuscular botulinum toxin type A for upper-limb spasticity in patients after a stroke. ArchPhys Med Rehabil, 2004, 85: 1063-1069.</mixed-citation><mixed-citation xml:lang="en">Childers M, Brashear A, Jozefczyk P, Reding M, Alexander D, Good D. Dose-dependent response to intramuscular botulinum toxin type A for upper-limb spasticity in patients after a stroke. ArchPhys Med Rehabil, 2004, 85: 1063-1069.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Gordon M, Brashear A, Elovic E, Kassicieh D, Marciniak C. Botox Post-Stroke Spasticity Study Group. Repeated dosing of botulinum toxin type A for upper limb spasticity following stroke. Neurology, 2004, 63: 1 971-1973.</mixed-citation><mixed-citation xml:lang="en">Gordon M, Brashear A, Elovic E, Kassicieh D, Marciniak C. Botox Post-Stroke Spasticity Study Group. Repeated dosing of botulinum toxin type A for upper limb spasticity following stroke. Neurology, 2004, 63: 1 971-1973.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Hesse S, Reiter F, Konrad M, Jahnke M. Botulinum toxin type A and short-term electrical stimulation in the treatment of upper limb flexor spasticity after stroke: a randomized, double-b lind, placebo-controlled trial. Clin Rehabil, 1998, 12: 381-388.</mixed-citation><mixed-citation xml:lang="en">Hesse S, Reiter F, Konrad M, Jahnke M. Botulinum toxin type A and short-term electrical stimulation in the treatment of upper limb flexor spasticity after stroke: a randomized, double-b lind, placebo-controlled trial. Clin Rehabil, 1998, 12: 381-388.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Pandyan A, Vuadens P, van Wijck F, Stark S, Johnson G, Barnes M. Are we underestimating the clinical efficacy of botulinum toxin (type A)? Quantifying changes in spasticity, strength and upper limb function after injections of Botox to the elbow flexors in a unilateral stroke population. Clin Rehabil, 2002, 16: 654-660.</mixed-citation><mixed-citation xml:lang="en">Pandyan A, Vuadens P, van Wijck F, Stark S, Johnson G, Barnes M. Are we underestimating the clinical efficacy of botulinum toxin (type A)? Quantifying changes in spasticity, strength and upper limb function after injections of Botox to the elbow flexors in a unilateral stroke population. Clin Rehabil, 2002, 16: 654-660.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Rousseaux M, Kozlowski O, Froger J. Efficacy of botulinum toxin A in upper limb function of hemiplegic patients. J Neurol, 2002, 249: 76-84.</mixed-citation><mixed-citation xml:lang="en">Rousseaux M, Kozlowski O, Froger J. Efficacy of botulinum toxin A in upper limb function of hemiplegic patients. J Neurol, 2002, 249: 76-84.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Ryuji K, Yuka O, Kazuaki S, Toshio M, Yasuyuki U. Botulinum toxin type A in post-stroke lower limb spasticity: a multicenter, double-blind, placebo-controlled trial . J Neurol, 2008, 257: 1330-1337.</mixed-citation><mixed-citation xml:lang="en">Ryuji K, Yuka O, Kazuaki S, Toshio M, Yasuyuki U. Botulinum toxin type A in post-stroke lower limb spasticity: a multicenter, double-blind, placebo-controlled trial . J Neurol, 2008, 257: 1330-1337.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Bayram S, Sivrioglu K, Karli N, Ozcan O. Lowdose botulinum toxin with short-term electrical stimulation in post-stroke spastic drop foot: a preliminary study. Am J Phys Med Rehabil, 2006, 85: 75-81.</mixed-citation><mixed-citation xml:lang="en">Bayram S, Sivrioglu K, Karli N, Ozcan O. Lowdose botulinum toxin with short-term electrical stimulation in post-stroke spastic drop foot: a preliminary study. Am J Phys Med Rehabil, 2006, 85: 75-81.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Dengler R, NeyerU, Wohlfarth K, Bettig U., Janzik H. Local botulinum toxin in the treatment of spastic drop foot. J Neurol, 1992, 239: 375-378.</mixed-citation><mixed-citation xml:lang="en">Dengler R, NeyerU, Wohlfarth K, Bettig U., Janzik H. Local botulinum toxin in the treatment of spastic drop foot. J Neurol, 1992, 239: 375-378.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Ward A. A literature review of the pathophysiology and onset of post-stroke spasticity. Eur J Neurol, 2012, 19: 21-27.</mixed-citation><mixed-citation xml:lang="en">Ward A. A literature review of the pathophysiology and onset of post-stroke spasticity. Eur J Neurol, 2012, 19: 21-27.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Hesse S, Jahnke M, Luecke D, Mauritz K. Shortterm electrical stimulation enhances the effectiveness of Botulinum toxin in the treatment of lower limb spasticity in hemiparetic patients. Neurosci Lett, 1995, 201: 37 -40.</mixed-citation><mixed-citation xml:lang="en">Hesse S, Jahnke M, Luecke D, Mauritz K. Shortterm electrical stimulation enhances the effectiveness of Botulinum toxin in the treatment of lower limb spasticity in hemiparetic patients. Neurosci Lett, 1995, 201: 37 -40.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Pittock S, Moore A, Hardiman O. A double-blindrandomized placebo-controlled evaluation of three doses of botulinum toxin type A (Dysport). J Neurol Neurosurg Psychiatry, 1999, 58: 1345-1349.</mixed-citation><mixed-citation xml:lang="en">Pittock S, Moore A, Hardiman O. A double-blindrandomized placebo-controlled evaluation of three doses of botulinum toxin type A (Dysport). J Neurol Neurosurg Psychiatry, 1999, 58: 1345-1349.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Thibaut A, Chatelle C, Ziegler E, Bruno MA, Laureys S, Gosseries O. Spasticity after stroke: physiology, assessment and treatment. Brain Inj, 2013, 27: 1093-1105.</mixed-citation><mixed-citation xml:lang="en">Thibaut A, Chatelle C, Ziegler E, Bruno MA, Laureys S, Gosseries O. Spasticity after stroke: physiology, assessment and treatment. Brain Inj, 2013, 27: 1093-1105.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Opheim A, Danielsson A, Alt Murphy M, Persson HC, Sunnerhagen K. Upper limb spasticity during the first year after stroke: a longitudinal study at the University of Gothenburg (SALGOT ). Am J Phys Med Rehabil, 2014, 93: 884-896.</mixed-citation><mixed-citation xml:lang="en">Opheim A, Danielsson A, Alt Murphy M, Persson HC, Sunnerhagen K. Upper limb spasticity during the first year after stroke: a longitudinal study at the University of Gothenburg (SALGOT ). Am J Phys Med Rehabil, 2014, 93: 884-896.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Костенко Е.В., Петрова Л.В., Ганжула П.Н., Хозова А.А., Бойко А.Н. Опыт применения ксеомина в коррекции спастичности руки в ранний восстановительный период инсульта. Журнал неврологии и психиатрии им. С.С. Корсакова, 2012, 112, 2: 29-3. [Kostenko E.V., Petrova L.V., Ganzhula P.N., Khozova A.A. , Boyko A.N. Experience of xeomin use for correction of hand spasticity at an early rehabilitation period after stroke. Zhurnal Nevrologii I Psikhiatrii im. S.S. Korsakova, 2012, 112, 2:29-3]</mixed-citation><mixed-citation xml:lang="en">Костенко Е.В., Петрова Л.В., Ганжула П.Н., Хозова А.А., Бойко А.Н. Опыт применения ксеомина в коррекции спастичности руки в ранний восстановительный период инсульта. Журнал неврологии и психиатрии им. С.С. Корсакова, 2012, 112, 2: 29-3. [Kostenko E.V., Petrova L.V., Ganzhula P.N., Khozova A.A. , Boyko A.N. Experience of xeomin use for correction of hand spasticity at an early rehabilitation period after stroke. Zhurnal Nevrologii I Psikhiatrii im. S.S. Korsakova, 2012, 112, 2:29-3]</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
