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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2016-17-100-105</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-1591</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Место стимулирующих слабительных средств в терапии запоров</article-title><trans-title-group xml:lang="en"><trans-title>Place of stimulating laxatives in therapy of constipations</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плотникова</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Plotnikova</surname><given-names>E. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><bio xml:lang="en"><p>MD, Prof.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Золотухина</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zolotukhina</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>PhD in medicine</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Грачева</surname><given-names>Т. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Gracheva</surname><given-names>T. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><bio xml:lang="en"><p>MD, Prof.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Кемеровский государственный медицинский университет Минздрава России<country>Россия</country></aff><aff xml:lang="en">Kemerovo State Medical University of the Ministry of Health of Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Городская клиническая больница №2, г. Кемерово<country>Россия</country></aff><aff xml:lang="en">Municipal Clinical Hospital No.2, Kemerovo<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>17</issue><fpage>100</fpage><lpage>105</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Плотникова Е.Ю., Золотухина В.Н., Грачева Т.Ю., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Плотникова Е.Ю., Золотухина В.Н., Грачева Т.Ю.</copyright-holder><copyright-holder xml:lang="en">Plotnikova E.Y., Zolotukhina V.N., Gracheva T.Y.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/1591">https://www.med-sovet.pro/jour/article/view/1591</self-uri><abstract><p>В статье приводятся зарубежные и российские эпидемиологические данные по распространенности запоров, подробно рассматриваются их причины и классификация. Описаны основные нефармакологические принципы, а также группы лекарственных препаратов, которые применяются при данной патологии. Представлен анализ отечественного фармацевтического рынка слабительных средств за последние годы. Стимулирующие слабительные средства чаще других востребованы пациентами. Пикосульфат натрия  – один из основных препаратов из группы стимулирующих слабительных. Авторы приводят результаты нескольких исследований по эффективности пикосульфата натрия и обсуждают, почему это средство остается одним из самых употребляемых при запорах. </p></abstract><trans-abstract xml:lang="en"><p>The article provides foreign and Russian epidemiological data on constipation incidence, their reasons and classifications are considered in detail. The section Constipation Therapy describes non-pharmacological principles as well as groups of drugs that are used for this pathology. An analysis of the Russian pharmaceutical market of laxative drugs in the recent years is presented. Stimulating laxatives are used by patients more often. Sodium picosulphate is one of the major drugs from group of stimulating laxatives. Authors cite results of several studies on effectiveness of sodium picosulphate and discuss why this drug is one of the most frequently used for constipations. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>запоры</kwd><kwd>слабительные средства</kwd><kwd>пикосульфат натрия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>constipations</kwd><kwd>laxative drugs</kwd><kwd>Sodium picosulphate</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Приворотский В.Ф., Луппова Н.Е. Современные подходы к лечению функциональных запоров у детей. РЖГГК, 2009, 19(1): 59-65.</mixed-citation><mixed-citation xml:lang="en">Приворотский В.Ф., Луппова Н.Е. Современные подходы к лечению функциональных запоров у детей. РЖГГК, 2009, 19(1): 59-65.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">WGO/OMGE. Запор. Практическое руководство Всемирной организации гастроэнтерологов. http://www.worldgastroenterology.org/ constipation.html.</mixed-citation><mixed-citation xml:lang="en">WGO/OMGE. Запор. Практическое руководство Всемирной организации гастроэнтерологов. http://www.worldgastroenterology.org/ constipation.html.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Sonnenberg A, KochTR. Physician visits in the United States for constipation: 1958 to 1986. Digestive Diseases and Science, 1989, 34(4): 606-611.</mixed-citation><mixed-citation xml:lang="en">Sonnenberg A, KochTR. Physician visits in the United States for constipation: 1958 to 1986. Digestive Diseases and Science, 1989, 34(4): 606-611.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Плотникова Е.Ю. Современные представления о запоре. Лечащий врач, 2015, 8: 7-18.</mixed-citation><mixed-citation xml:lang="en">Плотникова Е.Ю. Современные представления о запоре. Лечащий врач, 2015, 8: 7-18.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Rome III Criteria for Constipation. http://www. romecriteria.org/assets/pdf/19_RomeIII_ apA_885-898.pdf.</mixed-citation><mixed-citation xml:lang="en">Rome III Criteria for Constipation. http://www. romecriteria.org/assets/pdf/19_RomeIII_ apA_885-898.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">ADIL E. BHARUCHA, JOHN H. PEMBERTON, and G. RICHARD LOCKE, III American Gastroenterological Association Technical Review on Constipation Gastroenterology, Jan 2013, 144(1): 218-238.</mixed-citation><mixed-citation xml:lang="en">ADIL E. BHARUCHA, JOHN H. PEMBERTON, and G. RICHARD LOCKE, III American Gastroenterological Association Technical Review on Constipation Gastroenterology, Jan 2013, 144(1): 218-238.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Degen LP, Phillips SF. How well does stool form reflect colonic transit? Gut, 1996, 39: 109-113.; Saad RJ, Rao SSC, Koch KL et al. Do stool form and frequency correlate with whole-gut and colonic transit? Results from a multicenter study in constipated individuals and healthy controls. Am J Gastroenterol, 2010, 105: 403-411.</mixed-citation><mixed-citation xml:lang="en">Degen LP, Phillips SF. How well does stool form reflect colonic transit? Gut, 1996, 39: 109-113.; Saad RJ, Rao SSC, Koch KL et al. Do stool form and frequency correlate with whole-gut and colonic transit? Results from a multicenter study in constipated individuals and healthy controls. Am J Gastroenterol, 2010, 105: 403-411.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">McKay SL, Fravel M, Scanlon C. Management of constipation. owa City (IA): University of Iowa Gerontological Nursing Interventions Research Center, Research Translation and Dissemination Core, 2009: 51.</mixed-citation><mixed-citation xml:lang="en">McKay SL, Fravel M, Scanlon C. Management of constipation. owa City (IA): University of Iowa Gerontological Nursing Interventions Research Center, Research Translation and Dissemination Core, 2009: 51.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Аптечные продажи слабительных средств. Московские аптеки (фармацевтическая газе- та). 2013. http://mosapteki.ru/material/ aptechnye-prodazhi-slabitelnyx-sredstv-1386</mixed-citation><mixed-citation xml:lang="en">Аптечные продажи слабительных средств. Московские аптеки (фармацевтическая газе- та). 2013. http://mosapteki.ru/material/ aptechnye-prodazhi-slabitelnyx-sredstv-1386</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Зайчикова М.С. Слабительные препараты. Мониторинг аптечных продаж. 2016. Сайт для специалистов аптек: http://farmsfera.ru/practice/ assortiment-i-tseny/slabitelnye-preparaty/</mixed-citation><mixed-citation xml:lang="en">Зайчикова М.С. Слабительные препараты. Мониторинг аптечных продаж. 2016. Сайт для специалистов аптек: http://farmsfera.ru/practice/ assortiment-i-tseny/slabitelnye-preparaty/</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Passmore AP, Wilson-Davies K, Stoker C, Scott ME. Chronic constipation in long-stay elderly patients: a comparison of lactulose and a senna-fibre combination. BMJ, 1993, 307: 769-771.</mixed-citation><mixed-citation xml:lang="en">Passmore AP, Wilson-Davies K, Stoker C, Scott ME. Chronic constipation in long-stay elderly patients: a comparison of lactulose and a senna-fibre combination. BMJ, 1993, 307: 769-771.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Sonnenberg A, Müller AD. Constipation and cathartics as risk factors of colorectal cancer: a meta-analysis. Pharmacology, 1993, 47(Suppl 1): 224-233.</mixed-citation><mixed-citation xml:lang="en">Sonnenberg A, Müller AD. Constipation and cathartics as risk factors of colorectal cancer: a meta-analysis. Pharmacology, 1993, 47(Suppl 1): 224-233.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Dufour P, Gendre P. Ultrastructure of mouse intestinal mucosa and changes observed after long term anthraquinone administration. Gut, 1984, 25: 1358-1363.</mixed-citation><mixed-citation xml:lang="en">Dufour P, Gendre P. Ultrastructure of mouse intestinal mucosa and changes observed after long term anthraquinone administration. Gut, 1984, 25: 1358-1363.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kiernan JA, Heinicke EA. Sennosides do not kill myenteric neurons in the colon of the rat or mouse. Neuroscience, 1989, 30: 837-842.</mixed-citation><mixed-citation xml:lang="en">Kiernan JA, Heinicke EA. Sennosides do not kill myenteric neurons in the colon of the rat or mouse. Neuroscience, 1989, 30: 837-842.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Leon SH, Krishnamurthy S, Schuffler MD. Subtotal colectomy for severe idiopathic constipation. A follow-up study of 13 patients. Dig Dis Sci, 1987, 32: 1249-1254.</mixed-citation><mixed-citation xml:lang="en">Leon SH, Krishnamurthy S, Schuffler MD. Subtotal colectomy for severe idiopathic constipation. A follow-up study of 13 patients. Dig Dis Sci, 1987, 32: 1249-1254.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Müller-Lissner SA, Kamm MA, Scarpignato C, Wald A. Myths and misconceptions about chronic constipation. Amer J Gastroenterol, 2005, 100: 232-242.</mixed-citation><mixed-citation xml:lang="en">Müller-Lissner SA, Kamm MA, Scarpignato C, Wald A. Myths and misconceptions about chronic constipation. Amer J Gastroenterol, 2005, 100: 232-242.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Freeman HJ. «Melanosis» in the small and large intestine. World J Gastroenterol, 2008 Jul 21, 14(27): 4296-9.</mixed-citation><mixed-citation xml:lang="en">Freeman HJ. «Melanosis» in the small and large intestine. World J Gastroenterol, 2008 Jul 21, 14(27): 4296-9.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Freeman HJ, Lotan R, Kim YS. Application of lectins for detection of goblet cell glycoconjugate differences in proximal and distal colon of the rat. Lab Invest, 1980, 42: 405-412.</mixed-citation><mixed-citation xml:lang="en">Freeman HJ, Lotan R, Kim YS. Application of lectins for detection of goblet cell glycoconjugate differences in proximal and distal colon of the rat. Lab Invest, 1980, 42: 405-412.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Passmore AP, Wilson-Davies K, Stoker C, Scott ME. Chronic constipation in long stay elderly patients: a comparison of lactulose and a senna-fibre combination. BMJ, 1993 Sep 25, 307(6907): 769-71.</mixed-citation><mixed-citation xml:lang="en">Passmore AP, Wilson-Davies K, Stoker C, Scott ME. Chronic constipation in long stay elderly patients: a comparison of lactulose and a senna-fibre combination. BMJ, 1993 Sep 25, 307(6907): 769-71.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Gordon M, Naidoo K, Akobeng AK, Thomas AG. Cochrane Review: Osmotic and stimulant laxatives for the management of childhood constipation (Review). Evid Based Child Health, 2013 Jan, 8(1): 57-109.</mixed-citation><mixed-citation xml:lang="en">Gordon M, Naidoo K, Akobeng AK, Thomas AG. Cochrane Review: Osmotic and stimulant laxatives for the management of childhood constipation (Review). Evid Based Child Health, 2013 Jan, 8(1): 57-109.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Louvel D, Delvaux M, Staumont G, et al. Intracolonic injection of glycerol: a model for abdominal pain in irritable bowel syndrome? Gastroenterology, 1996, 110: 351-361.</mixed-citation><mixed-citation xml:lang="en">Louvel D, Delvaux M, Staumont G, et al. Intracolonic injection of glycerol: a model for abdominal pain in irritable bowel syndrome? Gastroenterology, 1996, 110: 351-361.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ewe K, Holker B. The effect of a diphenolic laxative (Bisacodyl) on water- and electrolyte transport in the human colon [author’s translation]. Klin Wochenschr, 1974, 52: 827-833.</mixed-citation><mixed-citation xml:lang="en">Ewe K, Holker B. The effect of a diphenolic laxative (Bisacodyl) on water- and electrolyte transport in the human colon [author’s translation]. Klin Wochenschr, 1974, 52: 827-833.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Manabe N, Cremonini F, Camilleri M et al. Effects of bisacodyl on ascending colon emptying and overall colonic transit in healthy volunteers. Aliment Pharmacol Ther, 2009, 30: 930-936.</mixed-citation><mixed-citation xml:lang="en">Manabe N, Cremonini F, Camilleri M et al. Effects of bisacodyl on ascending colon emptying and overall colonic transit in healthy volunteers. Aliment Pharmacol Ther, 2009, 30: 930-936.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kienzle-Horn S, Vix JM, Schuijt C, Peil H, Jordan CC, Kamm MA. Comparison of bisacodyl and sodium picosulfate in the treatment of chronic constipation. Curr Med Res Opinion, 2007, 23: 891-899.</mixed-citation><mixed-citation xml:lang="en">Kienzle-Horn S, Vix JM, Schuijt C, Peil H, Jordan CC, Kamm MA. Comparison of bisacodyl and sodium picosulfate in the treatment of chronic constipation. Curr Med Res Opinion, 2007, 23: 891-899.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kamm M, Mueller-Lissner S, Wald A, et al. Stimulant laxatives are effective in chronic constipation: multi-center, 4-week, doubleblind, randomized, placebo-controlled trial of bisacodyl. Gastroenterology, 2010, 138(Suppl 1): S228.</mixed-citation><mixed-citation xml:lang="en">Kamm M, Mueller-Lissner S, Wald A, et al. Stimulant laxatives are effective in chronic constipation: multi-center, 4-week, doubleblind, randomized, placebo-controlled trial of bisacodyl. Gastroenterology, 2010, 138(Suppl 1): S228.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Электронная энциклопедия лекарств и товаров аптечного ассортимента. http://www. rlsnet.ru/mnn_index_id_1726.htm.</mixed-citation><mixed-citation xml:lang="en">Электронная энциклопедия лекарств и товаров аптечного ассортимента. http://www. rlsnet.ru/mnn_index_id_1726.htm.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Bengtsson M, Ohlsson B. Retrospective study of long-term treatment with sodium picosulfate. Eur J Gastroenterol Hepatol, 2004, 16: 433-434.</mixed-citation><mixed-citation xml:lang="en">Bengtsson M, Ohlsson B. Retrospective study of long-term treatment with sodium picosulfate. Eur J Gastroenterol Hepatol, 2004, 16: 433-434.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Mueller-Lissner S, Kamm MA, Wald A et al. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation. Am J Gastroenterol, 2010, 105: 897-903.</mixed-citation><mixed-citation xml:lang="en">Mueller-Lissner S, Kamm MA, Wald A et al. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation. Am J Gastroenterol, 2010, 105: 897-903.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Rossol S. Constipation in patients with diabetes mellitus. MMW Fortschr Med, 2007 Nov 1, 149(44): 39-42.</mixed-citation><mixed-citation xml:lang="en">Rossol S. Constipation in patients with diabetes mellitus. MMW Fortschr Med, 2007 Nov 1, 149(44): 39-42.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Bengtsson M, Ohlsson B. Psychological wellbeing and symptoms in women with chronic constipation treated with sodium picosulphate. Gastroenterol Nurs, 2005 Jan-Feb, 28(1): 3-12.</mixed-citation><mixed-citation xml:lang="en">Bengtsson M, Ohlsson B. Psychological wellbeing and symptoms in women with chronic constipation treated with sodium picosulphate. Gastroenterol Nurs, 2005 Jan-Feb, 28(1): 3-12.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Wulkow R, Vix JM, Schuijt C, Peil H, Kamm MA, Jordan C. Randomised, placebo-controlled, double-blind study to investigate the efficacy and safety of the acute use of sodium picosulphate in patients with chronic constipation. Int J Clin Pract, 2007 Jun, 61(6): 944-50.</mixed-citation><mixed-citation xml:lang="en">Wulkow R, Vix JM, Schuijt C, Peil H, Kamm MA, Jordan C. Randomised, placebo-controlled, double-blind study to investigate the efficacy and safety of the acute use of sodium picosulphate in patients with chronic constipation. Int J Clin Pract, 2007 Jun, 61(6): 944-50.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
