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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2016-19-28-36</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-1624</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕВРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEUROLOGY</subject></subj-group></article-categories><title-group><article-title>АЛКОГОЛЬНАЯ ЗАВИСИМОСТЬ И ДЕПРЕССИЯ: ПОДХОДЫ К ДИАГНОСТИКЕ И ЛЕЧЕНИЮ</article-title><trans-title-group xml:lang="en"><trans-title>ALCOHOL ADDICTION AND DEPRESSION: APPROACHES TO DIAGNOSTICS AND THERAPY</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>АНДРЮЩЕНКО</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>ANDRYUSCHENKO</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><bio xml:lang="en"><p>MD, Prof.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ШУЛЯК</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>SHULYAK</surname><given-names>Y. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>PhD in medicine</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Психиатрическая клиническая больница №1 им. Н.А. Алексеева Департамента здравоохранения г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Alexeev Psychiatric Clinical Hospital No. 1 of the Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>19</issue><fpage>28</fpage><lpage>36</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; АНДРЮЩЕНКО А.В., ШУЛЯК Ю.А., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">АНДРЮЩЕНКО А.В., ШУЛЯК Ю.А.</copyright-holder><copyright-holder xml:lang="en">ANDRYUSCHENKO A.V., SHULYAK Y.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/1624">https://www.med-sovet.pro/jour/article/view/1624</self-uri><abstract><p>Новая стратегия ведения больных с проявлениями алкогольной зависимости, основанная на многоуровневом биопсихосоциальном подходе, предполагает комплексные терапевтические программы с использованием инновационных лекарственных средств и активное участие пациентов в этом процессе. В рамках этой стратегии, направленной на сокращение употребления спиртного у лиц с диагностированной алкогольной зависимостью, тестируется инновационный препарат налмефен – модулятор опиоидной системы двойного действия, т. к. в результате сравнительных рандомизированных исследований и методов метаанализа подтверждена его безопасность и эффективность. Новая тактика адъювантной терапии с применением налмефена получает все большее распространение в России.</p></abstract><trans-abstract xml:lang="en"><p>A new strategy of management of patients with signs of alcoholic dependence based on the multi-level biopsycosocial approach presupposes complex therapeutic programs with use of innovative drugs and active participation of patients in this process. Within this strategy aimed at reduction of alcohol consumption in patients with the diagnosed alcohol addiction an innovative drug Nalmefen – a modulator of the double-action opioid system is tested as as a result of the comparative randomized studies and meta-analysis methods its safety and effectiveness are proved. A new tactics of the adjuvant therapy with use of Nalmefen becomes more widely used in Russia.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>алкогольная зависимость</kwd><kwd>депрессия</kwd><kwd>терапия</kwd><kwd>налмефен</kwd></kwd-group><kwd-group xml:lang="en"><kwd>alcohol addiction</kwd><kwd>depression</kwd><kwd>therapy</kwd><kwd>Nalmefen</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Альтшулер В.Б. Алкоголизм. М., 2010. 260 с.</mixed-citation><mixed-citation xml:lang="en">Альтшулер В.Б. Алкоголизм. М., 2010. 260 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Альтшулер В.Б., Иванец Н.Н., Кравченко С.Л. Женский алкоголизм: клинические аспекты. М., 2006. 216 с.</mixed-citation><mixed-citation xml:lang="en">Альтшулер В.Б., Иванец Н.Н., Кравченко С.Л. 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