<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2016-19-44-47</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-1626</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕВРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEUROLOGY</subject></subj-group></article-categories><title-group><article-title>КОМПЛЕКС ВИТАМИНОВ ГРУППЫ В В ЛЕЧЕНИИ НЕВРОЛОГИЧЕСКОЙ ПАТОЛОГИИ</article-title><trans-title-group xml:lang="en"><trans-title>B VITAMIN COMPLEX IN THE TREATMENT OF NEUROLOGICAL DISORDERS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>БЕЛЬСКАЯ</surname><given-names>Г. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>BEL’SKAYA</surname><given-names>G. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор</p><p>Челябинск</p></bio><bio xml:lang="en"><p>MD, Prof.</p><p>Chelyabinsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ЛУЗАНОВА</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>LUZANOVA</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p><p>Челябинск</p></bio><bio xml:lang="en"><p>PhD in medicine</p><p>Chelyabinsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>СЕРГИЕНКО</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>SERGIENKO</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Челябинск</p></bio><bio xml:lang="en"><p>Chelyabinsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>СТЕПАНОВА</surname><given-names>С. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>STEPANOVA</surname><given-names>S. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p><p>Челябинск</p></bio><bio xml:lang="en"><p>PhD in medicine</p><p>Chelyabinsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>МАКАРОВА</surname><given-names>Л. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>LAZAREVA</surname><given-names>L. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p><p>Челябинск</p></bio><bio xml:lang="en"><p>PhD in medicine</p><p>Chelyabinsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Южно-Уральский государственный медицинский университет Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>South Ural State Medical University, MoH RF</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>19</issue><fpage>44</fpage><lpage>47</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; БЕЛЬСКАЯ Г.Н., ЛУЗАНОВА Е.И., СЕРГИЕНКО Д.А., СТЕПАНОВА С.Б., МАКАРОВА Л.Д., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">БЕЛЬСКАЯ Г.Н., ЛУЗАНОВА Е.И., СЕРГИЕНКО Д.А., СТЕПАНОВА С.Б., МАКАРОВА Л.Д.</copyright-holder><copyright-holder xml:lang="en">BEL’SKAYA G.N., LUZANOVA E.I., SERGIENKO D.A., STEPANOVA S.B., LAZAREVA L.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/1626">https://www.med-sovet.pro/jour/article/view/1626</self-uri><abstract><p>Спектр заболеваний нервной системы, при которых патогенетически обоснованно применение витаминов группы В, прежде всего тиамина, пиридоксина и цианокобаламина, разнообразен. Он включает поражение центральной и периферической нервной системы дисметаболического, токсического, инфекционного генеза, неврологические проявления дегенеративных заболеваний позвоночника, болевые синдромы. Витамины группы В обладают нейропротективными и анальгетическими свойствами, сочетаются с препаратами из различных фармакологических классов, что позволяет добиться положительного терапевтического эффекта, используя более низкие дозы последних и уменьшая риск развития нежелательных побочных явлений.</p></abstract><trans-abstract xml:lang="en"><p>The spectrum of the nervous system diseases in which administration of B vitamins is pathogenetically justified, especially thiamine, pyridoxine and cyanocobalamin, is varied. The diseases include dysmetabolic, toxic, infectious lesions of the central and peripheral nervous system, neurological manifestation of degenerative spine diseases, and pain syndromes. B-group vitamins possess neuroprotective and analgesic properties, can be combined with other pharmacological classes of drugs, thus allowing to achieve a positive therapeutic effect with a lower dose of those and reducing the risk of adverse effects.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>полинейропатия</kwd><kwd>боль</kwd><kwd>нейропатическая боль</kwd><kwd>алкоголизм</kwd><kwd>демиелинизация</kwd><kwd>витамины группы В</kwd><kwd>тиамин</kwd><kwd>пиридоксин</kwd><kwd>цианокобаламин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>polyneuropathy</kwd><kwd>pain</kwd><kwd>neuropathic pain</kwd><kwd>alcoholism</kwd><kwd>demyelination</kwd><kwd>B-group vitamins</kwd><kwd>thiamine</kwd><kwd>pyridoxine</kwd><kwd>cyanocobalamin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Brady S, Siegel GR, Albers W, Price D. Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 7th ed. Academic Press, 2005, 1016 p.</mixed-citation><mixed-citation xml:lang="en">Brady S, Siegel GR, Albers W, Price D. Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 7th ed. Academic Press, 2005, 1016 p.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Valdés-Ramos R, Guadarrama-López AL, Martínez-Carrillo BE, Benítez-Arciniega AD. Vitamins and type 2 diabetes mellitus. Endocr Metab Immune Disord Drug Targets, 2015, 15(1): 54-63.</mixed-citation><mixed-citation xml:lang="en">Valdés-Ramos R, Guadarrama-López AL, Martínez-Carrillo BE, Benítez-Arciniega AD. Vitamins and type 2 diabetes mellitus. Endocr Metab Immune Disord Drug Targets, 2015, 15(1): 54-63.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Старчина Ю.А. Витамины группы В в лечении заболеваний нервной системы. Неврология, нейропсихиатрия, психосоматика, 2009, 2: 84-87.</mixed-citation><mixed-citation xml:lang="en">Старчина Ю.А. Витамины группы В в лечении заболеваний нервной системы. Неврология, нейропсихиатрия, психосоматика, 2009, 2: 84-87.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Гурьева И.В., Левин О.С. Диабетическая полинейропатия. Consilium Medicum, 2014, 16(4): 12-19.</mixed-citation><mixed-citation xml:lang="en">Гурьева И.В., Левин О.С. Диабетическая полинейропатия. Consilium Medicum, 2014, 16(4): 12-19.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan, 2005, 14(2): 48-54.</mixed-citation><mixed-citation xml:lang="en">Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan, 2005, 14(2): 48-54.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Mibielli MA, Geller M, Cohen JC, Goldberg SG, Cohen MT, Nunes CP et al. Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR study. Curr Med Res Opin, 2009 Nov, 25(11): 2589-2599. doi: 10.3111/13696990903246911.</mixed-citation><mixed-citation xml:lang="en">Mibielli MA, Geller M, Cohen JC, Goldberg SG, Cohen MT, Nunes CP et al. Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR study. Curr Med Res Opin, 2009 Nov, 25(11): 2589-2599. doi: 10.3111/13696990903246911.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Magaña-Villa MC, Rocha-González HI, Fernández del Valle-Laisequilla C, Granados-Soto V, Rodríguez-Silverio J, Flores-Murrieta J, Carrasco- Portugal MC et al. B-vitamin mixture improves the analgesic effect of diclofenac in patients with osteoarthritis: a double blind study. Drug Res (Stuttg), 2013 Jun, 63(6): 289-292. doi: 10.1055/s-0033-1334963.</mixed-citation><mixed-citation xml:lang="en">Magaña-Villa MC, Rocha-González HI, Fernández del Valle-Laisequilla C, Granados-Soto V, Rodríguez-Silverio J, Flores-Murrieta J, Carrasco- Portugal MC et al. B-vitamin mixture improves the analgesic effect of diclofenac in patients with osteoarthritis: a double blind study. Drug Res (Stuttg), 2013 Jun, 63(6): 289-292. doi: 10.1055/s-0033-1334963.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ponce-Monter HA, Ortiz MI, Garza-Hernández AF, Monroy-Maya R, Soto-Ríos M, Carrillo- Alarcón L et al. Effect of diclofenac with B vitamins on the treatment of acute pain originated by lowerlimb fracture and surgery. Pain Res reat, 2012, 2012: 104782. doi: 10.1155/2012/104782.</mixed-citation><mixed-citation xml:lang="en">Ponce-Monter HA, Ortiz MI, Garza-Hernández AF, Monroy-Maya R, Soto-Ríos M, Carrillo- Alarcón L et al. Effect of diclofenac with B vitamins on the treatment of acute pain originated by lowerlimb fracture and surgery. Pain Res reat, 2012, 2012: 104782. doi: 10.1155/2012/104782.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьева О.В. Рациональная мультимодальная терапия боли в спине. Нервные болезни. Атмосфера, 2013, 2: 18-22.</mixed-citation><mixed-citation xml:lang="en">Воробьева О.В. Рациональная мультимодальная терапия боли в спине. Нервные болезни. Атмосфера, 2013, 2: 18-22.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kopruszinski CM, Reis RC, Chichorro JG. B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats. Life Sci, 2012 Dec 10, 91(23-24): 1187- 1195. doi: 10.1016/j.lfs.2012.08.025.</mixed-citation><mixed-citation xml:lang="en">Kopruszinski CM, Reis RC, Chichorro JG. B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats. Life Sci, 2012 Dec 10, 91(23-24): 1187- 1195. doi: 10.1016/j.lfs.2012.08.025.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ullegaddi R, Powers HJ, Gariballa SE JPEN J Antioxidant supplementation with or without B-group vitamins after acute ischemic stroke: a randomized controlled trial. Parenter Enteral Nutr, 2006 Mar-Apr, 30(2): 108-114.</mixed-citation><mixed-citation xml:lang="en">Ullegaddi R, Powers HJ, Gariballa SE JPEN J Antioxidant supplementation with or without B-group vitamins after acute ischemic stroke: a randomized controlled trial. Parenter Enteral Nutr, 2006 Mar-Apr, 30(2): 108-114.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Aggunlu L, Oner Y, Kocer B, Akpek S. The value of diffusion-weighted imaging in the diagnosis of Marchiafava-Bignami disease: apropos of a case. J Neuroimaging, 2008 Apr, 18(2): 188-190, doi: 10.1111/j.1552-6569.2007.00202.x.</mixed-citation><mixed-citation xml:lang="en">Aggunlu L, Oner Y, Kocer B, Akpek S. The value of diffusion-weighted imaging in the diagnosis of Marchiafava-Bignami disease: apropos of a case. J Neuroimaging, 2008 Apr, 18(2): 188-190, doi: 10.1111/j.1552-6569.2007.00202.x.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kakkar C, Prakashini K, Polnaya A. Acute Marchiafava-Bignami disease: clinical and serial MRI correlation. BMJ Case Rep, 2014 May 21, 2014, pii: bcr2013203442, doi: 10.1136/bcr- 2013-203442.</mixed-citation><mixed-citation xml:lang="en">Kakkar C, Prakashini K, Polnaya A. Acute Marchiafava-Bignami disease: clinical and serial MRI correlation. BMJ Case Rep, 2014 May 21, 2014, pii: bcr2013203442, doi: 10.1136/bcr- 2013-203442.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Bano S, Mehra S, Yadav SN, Chaudhary V. Marchiafava-Bignami disease: Role of neuroimaging in the diagnosis and management of acute disease. Neurol India, 2009 Sep- Oct, 57(5): 649-652, doi: 10.4103/0028-3886.57811.</mixed-citation><mixed-citation xml:lang="en">Bano S, Mehra S, Yadav SN, Chaudhary V. Marchiafava-Bignami disease: Role of neuroimaging in the diagnosis and management of acute disease. Neurol India, 2009 Sep- Oct, 57(5): 649-652, doi: 10.4103/0028-3886.57811.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Левин О.С. Полиневропатии: Клиническое руководство. М.: Мед. информ. агентство, 2011. 490 с.</mixed-citation><mixed-citation xml:lang="en">Левин О.С. Полиневропатии: Клиническое руководство. М.: Мед. информ. агентство, 2011. 490 с.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Vetter G, Brüggemann G, Lettko M, Schwieger G, Asbach H, Biermann W et al. Shortening diclofenac therapy by B vitamins. Results of a randomized double-blind study, diclofenac 50 mg versus diclofenac 50 mg plus B vitamins, in painful spinal diseases with degenerative changes. [Article in German]. Z Rheumatol, 1988 Sep-Oct, 47(5): 351-362.</mixed-citation><mixed-citation xml:lang="en">Vetter G, Brüggemann G, Lettko M, Schwieger G, Asbach H, Biermann W et al. Shortening diclofenac therapy by B vitamins. Results of a randomized double-blind study, diclofenac 50 mg versus diclofenac 50 mg plus B vitamins, in painful spinal diseases with degenerative changes. [Article in German]. Z Rheumatol, 1988 Sep-Oct, 47(5): 351-362.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Jesse S, Ludolph AC. Thiamine, pyridoxine and cobalamine. From myths to pharmacology and clinical practice. [Article in German]. Nervenarzt, 2012 Apr, 83(4): 521- 532, quiz 533- 4, doi: 10.1007/s00115-011-3425-1.11</mixed-citation><mixed-citation xml:lang="en">Jesse S, Ludolph AC. Thiamine, pyridoxine and cobalamine. From myths to pharmacology and clinical practice. [Article in German]. Nervenarzt, 2012 Apr, 83(4): 521- 532, quiz 533- 4, doi: 10.1007/s00115-011-3425-1.11</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
