References

medsovet

Медицинский Совет

Meditsinskiy sovet = Medical Council

2079-701X2658-5790

REMEDIUM GROUP Ltd.

10.21518/2079-701X-2017-1-34-44

medsovet-1676

Research Article

НЕОНАТОЛОГИЯ

NEONATOLOGY

Мастит у женщин: новый взгляд на старую проблему

Mastitis in women: a new look at the old problem

Родригес

Хуан М.

Rodriguez

Juan M.

доктор

Doctor

Департамент по вопросам питания, диетологии и пищевых технологий, Мадридский университет КомплутенсеИспанияDepartment of Nutrition, Bromatology and Food Technology, the Complutense University of MadridSpain

2017

30122017

013444

2017

Родригес Х.

Rodriguez J.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.med-sovet.pro/jour/article/view/1676

Грудное молоко содержит представители микробиоты, влияющие не только на здоровье ребенка, но и на состояние молочных желез кормящей женщины как в краткосрочной, так и в долгосрочной перспективе. По сути, дисбиоз микробиоты грудного молока, вызванный нарушенным состоянием здоровья материнского организма, а также воздействием микробиологических и медицинских факторов, часто способствует развитию острого, подострого или субклинического мастита – патологии, которая нередко приводит к прекращению грудного вскармливания. Устойчивость к антибиотикам, способность к формированию биопленок, связыванию железа, а также влияние на иммунный ответ хозяина являются общими чертами современных бактериальных возбудителей (в основном стафилококков, стрептококков и коринебактерий), вызывающих в т. ч. и мастит. Это объясняет, почему человек становится невосприимчивым к антибактериальной терапии и почему разработка новых направлений лечения мастита на основе пробиотиков становится очень привлекательной. Некоторые штаммы лактобактерий, выделенных из молока, уже показали высокую эффективность для профилактики и лечения мастита у кормящих женщин.

Breast milk contains representatives of the microbiota which affect not only the health of child but also the condition of mammary glands in breastfeeding women both in the short and long term. In fact, dysbiosis of the breast milk microbiota caused by the mother’s body dysfunction as well as exposure to microbial and health factors, often contributes to the development of acute, subacute or subclinical mastitis. The pathology frequently results in the cessation of breastfeeding. Antibiotic resistance, ability to form biofilms, iron binding capacity, as well as the impact on the host’s immune response, are the common features of today’s bacterial pathogens (mainly staphylococci, streptococci and corynebacteria) which may also cause mastitis. This explains why people may become immune to antibiotic therapy, and why the development of new approaches in mastitis treatment using probiotics is becoming very attractive. Some strains of lactobacilli isolated from milk have already demonstrated high efficacy in the prevention and treatment of mastitis in lactating women.

грудное молокомикрофлорамаститдисбиозгрудное вскармливаниестафилококки (Staphylococcus)стрептококки (Streptococcus)коринебактерии (Corynebacterium)пробиотики

breast milkmicrofloramastitisdysbiosisbreastfeedingstaphylococci (Staphylococcus)streptococci (Streptococcus)corynebacteria (Corynebacterium)probiotics

References1

Lawrence RA, Lawrence RM. Breastfeeding. a guide for the medical profession. 7th ed., Saunders, Philadelphia. 2010.

Delgado S, Arroyo R, Jiménez E, Fernández L, Rodríguez JM.. Infectious mastitis during lactation: an underrated condition (I). ActaPediatrica Española, 2009а, 67: 77-84.

Jiménez E, Delgado S, Arroyo R, Fernández L, Rodríguez JM. Infectious mastitis during lactation: an underrated condition (II). ActaPediatrica Española, 2009, 67: 125-132.

Contreras GA, Rodriguez JM. Mastitis: comparative etiology and epidemiology. Journal of the Mammary Gland Biology and Neoplasia, 2011, 16: 339-356.

Fernández L, Arroyo R, Espinosa I, Marín M, Jiménez E, Rodríguez JM. Probiotics for human lactational mastitis. Beneficial Microbes, 2014, 5: 169-183.

Delgado S, Arroyo R, Martín R, Rodríguez JM. PCR-DGGE assessment of the bacterial diversity of breast milk in women with lactational infectious mastitis. BMC Infectious Diseases, 2008, 8: 51.

Arroyo R, Mediano P, Martín V, Jiménez E, Delgado S, Fernández L, Marín M, Rodríguez JM. Etiological diagnosis of infectious mastitis: proposal of a protocol for the culture of human milk samples ActaPediatrica Española, 2011, 69: 276-281.

Marín ML, Arroyo R, Jiménez E, Gómez A, Fernández L, Rodríguez JM. Cold storage of human milk: effect on its bacterial composition. Journal of Pediatric Gastroenterology and Nutrition, 2009, 49: 343-348.

Reddy P, Qi C, Zembower T, Noskin GA, Bolon M. Postpartum mastitis and community-acquired methicillin-resistant Staphylococcus aureus. Emerging Infectious Diseases, 2007, 13: 298-301.

Delgado S, García P, Fernández L, Jiménez E, Rodríguez-Baños M, del Campo R, Rodríguez JM. Characterization of Staphylococcus aureus strains involved in human and bovine mastitis. FEMS Immunological and Medical Microbiology, 2011, 62: 225-235.

Jiménez E, de Andrés J, Manrique M, Pareja-Tobes P, Tobes R, Martínez-Blanch JF, Codoñer FM, Ramón D, Fernández L, Rodríguez JM. Metagenomic analysis of milk of healthy and mastitis-suffering women. Journal of Human Lactation, 2015, 31: 406-415.

Thomsen AC, Mogensen S, Love Jepsen F. Experimental mastitis in mice induced by coagulase-negative staphylococci isolated from cases of mastitis in nursing women. ActaObstetricia et GynecologicaScandinavica, 1985, 64: 163-166.

Jimenez E, Fernandez L, Maldonado A, Martin R, Olivares M, Xaus J, Rodriguez JM. Oral administration of Lactobacillus strains isolated from breast milk as an alternative for the treatment of infectious mastitis during lactation. Applied and Environmental Microbiology, 2008a, 74: 4650-4655.

Delgado S, Arroyo R, Jiménez E, Marin ML, del Campo R, Fernandez L, Rodriguez JM. Staphylococcus epidermidis strains isolated from breast milk of women suffering infectious mastitis: potential virulence traits and resistance to antibiotics. BMC Microbiology, 2009b, 9: 82.

Arroyo R, Martin V, Maldonado A, Jimenez E, Fernandez L, Rodriguez JM. Treatment of infectious mastitis during lactation: antibiotics versus oral administration of lactobacilli isolated from breast milk. Clinical Infectious Diseases, 2010, 50: 1551-1558.

Martín V, Mediano P, Del Campo R, Rodríguez JM, Marín M. Streptococcal diversity of human milk and comparison of different methods for the taxonomic identification of streptococci. Journal of Human Lactation, DOI: 10.1177/0890334415597901.

Renshaw AA, Derhagopian RP, Gould EW. Cystic neutrophilic granulomatous mastitis: an underappreciated pattern strongly associated with gram-positive bacilli. American Journal of Clinical Pathology, 2011, 136: 424-427.

Paviour S, Musaad S, Roberts S, Taylor G, Taylor S, Shore K, Lang S, Holland D. Corynebacterium species isolated from patients with mastitis. Clinical Infectious Diseases, 2002, 35: 1434-1440.

Bercot B, Kannengiesser C, Oudin C, Grandchamp B, Pors MJSL, Mouly S, Elbim C. First description of NOD2 variant associated with defective neutrophil responses in a woman with granulomatous mastitis related to corynebacteria. Journal of Clinical Microbiology, 2009, 47: 3034-3037.

Fernández L, Langa S, Martín V, Maldonado A, Jiménez E, Martín R, Rodríguez JM. The human milk microbiota: origin and potential roles in health and disease. Pharmacological Research, 2013, 69: 1-10.

Soto A, Martín V, Jiménez E, Mader I, Rodríguez JM, Fernández L. Lactobacilli and bifidobacteria in human breast milk: influence of antibiotherapy and other host and clinical factors. J Pediatr Gastroenterol Nutr.

Hammer ND, Skaar EP. A battle for iron: host sequestration and Staphylococcus aureus acquisition. Microbes and Infection, 2012, 14: 217-227.

Jeurink PV, van Bergenhenegouwen J, Jimenez E, Knippels LM, Fernandez L, Garssen J, Knol J, Rodriguez JM, Martin R. Human milk: a source of more life than we imagine. Beneficial Microbes, 2013, 4: 17-30.

Espinosa-Martos I, Jiménez E, de Andrés J, Rodríguez-Alcalá LM, Tavárez S, Manzano S, Fernández L, Alonso E, Fontecha J, Rodríguez JM. Searching for milk and blood biomarkers associated to the clinical efficacy of a probiotic for the treatment of infectious mastitis. Beneficial Microbes, 2015, 7: 305-318.

Vázquez-Fresno R, Llorach R, Marinic J, Tulipani S, Garcia-Aloy M, Espinosa-Martos I, Jiménez E, Rodríguez, JM, Andres-Lacueva C. Urinary metabolomic fingerprinting after consumption of a probiotic strain in women with mastitis. Pharmacology Research, 2014, 87: 160-165.

Fernández L, Cárdenas N, Arroyo R, Manzano S, Jiménez E, Martín V, Rodríguez JM. Prevention of infectious mastitis by oral administration of Lactobacillus salivarius PS2 during late pregnancy. Clinical Infectious Disease, 2016, 62: 568-73.

Martín R, Olivares M, Marín ML, Fernández L, Xaus J, Rodríguez JM. Probiotic potential of 3 lactobacilli strains isolated from breast milk. Journal of Human Lactation, 2005, 21: 8-17.

Prescott SL, Wickens K, Westcott L, Jung W, Currie H, Black PN, Stanley TV, Mitchell EA, Fitzharris P, Siebers R, Wu L, Crane J. Probiotic Study Group. Supplementation with Lacto bacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-gamma and breast milk transforming growth factor-beta and immunoglobin A detection. Clinical and Experimental Allergy, 2008, 38: 1606-1614.

Nikniaz L, Ostadrahimi A, Mahdavi R, Hejazi MA, HosseiniSalekdeh G. Effects of synbiotic supplementation on breast milk levels of IgA, TGF-β1, and TGF-β2. Journal of Human Lactation, 2013, 29: 591-596.

The authors declare that there are no conflicts of interest present.