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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2017-2-38-44</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-1719</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Контрацепция</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Contraception</subject></subj-group></article-categories><title-group><article-title>КОМБИНИРОВАННАЯ ГОРМОНАЛЬНАЯ КОНТРАЦЕПЦИЯ, И НЕ ТОЛЬКО…</article-title><trans-title-group xml:lang="en"><trans-title>COMBINED HORMONAL CONTRACEPTION AND NOT ONLY…</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ерофеева</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Erofeeva</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">региональная общественная организация содействия охране репродуктивного здоровья граждан «Народонаселение и Развитие» (РАНиР)<country>Россия</country></aff><aff xml:lang="en">Regional Public Organization of Assistance in Population Reproductive Health Protection «Population and Development»<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2017</year></pub-date><volume>0</volume><issue>2</issue><fpage>38</fpage><lpage>44</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ерофеева Л.В., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Ерофеева Л.В.</copyright-holder><copyright-holder xml:lang="en">Erofeeva L.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/1719">https://www.med-sovet.pro/jour/article/view/1719</self-uri><abstract><p>Хлормадинона ацетат-содержащий комбинированный контрацептив (хлормадинона ацетат – ХМА) хорошо изучен, обладает высокой степенью надежности при длительном использовании в различных режимах, обладает протективными антиатерогенными свойствами и нивелированным риском для сердечно-сосудистой системы, так как существующие данные свидетельствуют о том, что риск развития тромбоэмболии на фоне хлормадинона сопоставим с аналогичным показателем препарата «первого поколения» прогестинов левоноргестрела, т. е. на сегодняшний день обладает минимальным риском тромбозов среди всех комбинированных оральных контрацептивов (КОК). Неоспоримым преимуществом ХМА-содержащих КОК является нейтральное воздействие на углеводный обмен и свертывающую систему крови при одновременном наличии у них антиатерогенного эффекта, что позволяет считать их препаратами выбора у пациенток со склерополикистозными яичниками, метаболическим синдромом и системными заболеваниями, сопровождающимися гиперкоагуляцией. Российские ученые и западные специалисты, изучавшие действие ХМА-содержащего комбинированного препарата, позволяют рекомендовать КОК Белара® для назначения не только с контрацептивной целью, но и как препарат, обеспечивающий стабильность менструального цикла, как препарат выбора при гиперполименорее, дисменорее, гиперандрогении, выраженной в виде проявлений акне, гирсутизма, жирной себореи, снижения сексуальной активности из-за диспареунии, а также с целью анксиолитического и седативного эффекта при предменструальном синдроме.</p></abstract><trans-abstract xml:lang="en"><p>Chlormadinone acetate-containing combined contraceptives are well researched, they have a high degree of reliability during prolonged use in different modes. They have a protective anti-atherogenic properties and is offset by the risk for cardiovascular system, because the existing data indicate that the risk of thromboembolism against the background of chlormadinone preparation is minimal to date among all COCs and is comparable with the «first-generation» progestins, like levonorgestrel. The undeniable advantage of CMA-containing COC is a neutral impact on carbohydrate metabolism and blood coagulation system. CMA COCs have anti-atherogenic effect, which makes them “the drugs of choice” in patients with sclerocystic ovaries, metabolic syndrome and systemic diseases associated with hypercoagulability.</p><p>Russian scholars and Western specialists who studied the effect of CMA-containing combination drug, allow us to recommend COC Belara® to assign not only with the contraceptive purpose, but also as a product for the stability of the menstrual cycle, as the drug of choice in the hyperpolimenorrhea, al’go – and dysmenorrhea, hyperandrogenism, expressed in the form of acne, hirsutism, oily seborrhea, decrease in sexual activity because of dyspareunia, as well as to anxiolytic and sedative effect in PMS. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>гормональные контрацептивы</kwd><kwd>КОК</kwd><kwd>хлормадинона ацетат</kwd><kwd>неконтрацептивные преимущества</kwd><kwd>СПКЯ</kwd><kwd>дисменорея</kwd><kwd>аменорея</kwd><kwd>акне</kwd><kwd>гиперандрогения</kwd><kwd>гирсутизм</kwd><kwd>жирная себорея</kwd><kwd>диспареуния</kwd><kwd>ПМС</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hormonal contraceptives</kwd><kwd>COC</kwd><kwd>chlormadinone acetate</kwd><kwd>non-contraceptive advantages</kwd><kwd>polycystic ovarian syndrome</kwd><kwd>disminorrhea</kwd><kwd>amenorrhea</kwd><kwd>acne</kwd><kwd>hyperandrogenia</kwd><kwd>hirsutism</kwd><kwd>seborrhea adiposa</kwd><kwd>dyspareunia</kwd><kwd>PMS</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">http://www.escrh.eu/events/esc-events/2016 (дата обращения 27.05.2016 ).</mixed-citation><mixed-citation xml:lang="en">http://www.escrh.eu/events/esc-events/2016 (дата обращения 27.05.2016 ).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Skouby SO. 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