medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-2-48-50medsovet-1721Research ArticleБеременность и родыPregnancy and childbirthВИТАМИНЫ ДЛЯ БЕРЕМЕННЫХ. АКТИВНЫЕ ФОЛАТЫ СО СТОПРОЦЕНТНЫМ УСВОЕНИЕМVITAMINS FOR PREGNANT, ACTIVE FOLATES WITH 100% ABSORPTIONХилькевичЕ. Г.KhilkevichE. G.

д.м.н.,

Москва

MD, 

Moscow 

ЯзыковаО. И.YazykovaO. I.

Москва

Moscow

Научный центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава РоссииРоссияAcademician Kulakov Scientific Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of RussiaRussian Federation201730122017024850Copyright © Хилькевич Е.Г., Языкова О.И., 20172017Хилькевич Е.Г., Языкова О.И.Khilkevich E.G., Yazykova O.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/1721Цель исследования

Цель исследования. Изучить эффективность применения препаратов фолиевой кислоты, в частности метафолина, на этапе прегравидарной подготовки и во время беременности с целью профилактики врожденных пороков развития и осложнений гестации.

Материал и методы

Материал и методы. По ключевым словам «фолиевая кислота», «фолаты», «метафолин», «беременность», «метилтетрагидрофолатредуктаза» нами проведен поиск литературных источников в отечественных и зарубежных БД: elibrary, Medline/ PubMed, Embase, CINAHL. Отобрано 23 источника.

Результаты исследования

Результаты исследования. Одной из основных задач, стоящих перед акушером-гинекологом, является профилактика осложнений беременности и врожденных пороков развития плода. В литературе имеется значительное количество данных, свидетельствующих об эффективности применения фолиевой кислоты. Однако естественные фолаты пищи, а также препараты фолиевой кислоты могут недостаточно усваиваться организмом у женщин с дефектами фолат-превращающих ферментов, распространенность которых достигает 50%.

Заключение

Заключение. Всем женщинам на этапе прегравидарной подготовки и во время беременности необходимо принимать фолаты с целью профилактики осложнений беременности и врожденных пороков развития плода. Учитывая высокую распространенность мутаций генов, отвечающих за фолат-превращающие ферменты, в клинической практике рекомендуется использование фолатов, способных усваиваться организмом независимо от генетических вариантов ферментов фолатного цикла. 

Study objective

Study objective. To study the efficacy of folic acid drugs, in particular metafolin, at the stage of pregravid preparation and during pregnancy to prevent congenital malformations and complications of pregnancy.

Material and methods

Material and methods. We conducted a search of the literature sources by the keywords «folic acid», «folates», «metafolin», «pregnancy», «methyltetrahydrofolate» in domestic and foreign databases: elibrary, Medline/PubMed, Embase, CINAHL. 23 sources were selected.

Study results

Study results. One of the main challenges that the obstetrician faces is the prevention of pregnancy complications and congenital malformations of the fetus. In the literature there is considerable amount of evidence about the effectiveness of folic acid. However, the natural food folates and folic acid preparations may not be absorbed to a sufficient degree by the body in women with defects in folate-converting enzymes, the incidence rate of which reaches 50%.

Conclusion

Conclusion. All women at the stage of pregravid preparation and during pregnancy should take folates to prevent complications of pregnancy and congenital malformations in the fetus. Given the high prevalence of mutations in genes responsible for folateconverting enzymes, in clinical practice it is recommended to use folates able to be absorbed by the body regardless of genetic variants of the folate cycle enzymes. 

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The authors declare that there are no conflicts of interest present.