medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-2-122-127medsovet-1735Research ArticleУРОЛОГИЯUROLOGYСОВРЕМЕННЫЕ ВОЗМОЖНОСТИ МЕДИКАМЕНТОЗНОГО ЛЕЧЕНИЯ ГИПЕРАКТИВНОГО МОЧЕВОГО ПУЗЫРЯ У ЖЕНЩИНMODERN POSSIBILITIES OF MEDICAL TREATMENT OF OVERACTIVE BLADDER IN WOMENАполихинаИ. А.ApolikhinaI. A.

д.м.н.,

Москва

MD,

Moscow

ЧочуеваА. С.ChochuevaA. S.

Москва

Moscow

СаидоваА. С.SaidovaA. S.

к.м.н.,

Москва

PhD in Medicine, 

Moscow

ГорбуноваЕ. А.GorbunovaE. A.

Москва

Moscow

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова Минздрава России; Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава РоссииРоссияResearch Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare of the Russian Federation; First Moscow State Medical University, Ministry of Healthcare of the Russian FederationRussian FederationНаучный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова Минздрава РоссииРоссияResearch Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare of the Russian FederationRussian Federation20173012201702122127Copyright © Аполихина И.А., Чочуева А.С., Саидова А.С., Горбунова Е.А., 20172017Аполихина И.А., Чочуева А.С., Саидова А.С., Горбунова Е.А.Apolikhina I.A., Chochueva A.S., Saidova A.S., Gorbunova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/1735

Гиперактивный мочевой пузырь (ГМП) – тяжелое расстройство мочеиспускания, которым страдают не менее 17% населения старше 40 лет, из них 56% женщин и 44% мужчин. М-холиноблокаторы являются первой линией препаратов, основным методом лечения ГМП. Однако побочные эффекты, наряду с недостаточной эффективностью, вынуждают женщин отказываться от приема данных препаратов. Известно, что активация бета-3-адренорецепторов способствует снижению тонуса детрузора  – мышцы мочевого пузыря. Это привело к разработке мирабегрона (Mirabegron, Бетмига, Astellas Pharma Europe, Нидерланды) – первого препарата новой фармакологической группы (бета-3-адреномиметики) для лечения ГМП. Являясь селективным бета-3-адреномиметиком, мирабегрон не оказывает таких побочных эффектов, как сухость во рту, повышение внутриглазного давления и запоры. В результате многочисленных клинических исследований было отмечено снижение эпизодов недержания мочи и частого мочеиспускания в группах мирабегрона по сравнению с группой плацебо.

Overactive bladder (OAB) is a serious urination disorder which affects at least 17% of the population above 40 years old, of which 56% are women and 44% are men. M-cholinoblockers are the first line therapy and the main treatment for OAB. However, their side effects, along with low efficacy, force women to stop taking the drugs. Activation of beta-3-adrenergic receptors is known toreduce the tone of detrusor muscle in the bladder. This resulted in the invention of mirabegron (Mirabegron, Betmiga, Astellas Pharma Europe, Netherlands), the first drug of a new pharmacologic group (beta-3 adrenergic agonists) for the treatment of OAB. A selective beta-3 agonist, mirabegron has no side effects such as dry mouth, increased intraocular pressure or constipation. Numerous clinical studies demonstrated a reduction in the number of episodes of urinary incontinence and frequent urination in the mirabegron group compared to the placebo group.

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The authors declare that there are no conflicts of interest present.