medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-3-32-37medsovet-1746Research ArticleСАХАРНЫЙ ДИАБЕТDIABETES MELLITUSКАРДИОВАСКУЛЯРНАЯ БЕЗОПАСНОСТЬ ГЛИПТИНОВ АКЦЕНТ НА АЛОГЛИПТИНCARDIOVASCULAR SAFETY OF GLIPTINS. FOCUS ON ALOGLIPTINПетунинаН. А.PetuninaN. A.

д.м.н., профессор,

MD, Prof.

ГончароваЕ. В.GoncharovaE. V.ПотаповаС. А.PotapovaS. A.Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава РоссииРоссияFirst Moscow State Medical University named after I.M. Sechenov, Russia’s Ministry of HealthRussian Federation201730122017033237Copyright © Петунина Н.А., Гончарова Е.В., Потапова С.А., 20172017Петунина Н.А., Гончарова Е.В., Потапова С.А.Petunina N.A., Goncharova E.V., Potapova S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/1746

Сахарный диабет 2-го типа представляет собой хроническое прогрессирующее заболевание с возрастающей распространенностью. Не прекращается разработка новых стратегий лечения диабета, среди которых стоит отметить и препараты, влияющие на «инкретиновый эффект». Ингибиторы дипептидилпептидазы 4-го типа (иДПП-4, глиптины) представляют собой группу пероральных сахароснижающих препаратов инкретинового ряда, вызывающих усиление глюкозозависимой активности β-клеток и подавление избыточной секреции глюкагона α-клетками поджелудочной железы. Эта группа сахаро снижающих препаратов получила широкое распространение благодаря ряду таких важных преимуществ, как нейтральное влияние на массу тела, низкий риск гипогликемии, удобный режим приема и хорошая приверженность к лечению. Показанная в ходе многоцентровых международных исследований эффективность и безопасность лечения дает возможность широкого применения глиптинов в клинической практике.

Type 2 diabetes is a chronic progressive disease the prevalence of which is increasing. The development of new strategies for the treatment of diabetes, among which drugs that modulate the “incretin effect” are worth noting, continues. Dipeptidyl peptidase-4 inhibitors (DPP-4, gliptins) are a group of oral antidiabetic incretin drugs that enhance the glucose-induced activity of β-cells and suppress excessive glucagon secretion by pancreatic α-cells. This group of antidiabetic drugs is widespread due to a number of relevant benefits, such as neutral effect on body weight, low risk of hypoglycaemia, convenient administration scheme and good adherence to treatment. Efficacy and safety of treatment demonstrated by global multicenter trials allow for a wide use of gliptins in clinical practice.

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The authors declare that there are no conflicts of interest present.