medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2015-5-106-111medsovet-180Research ArticleРЕВМАТОЛОГИЯRHEUMATOLOGYМесто ингибиторов фактора некроза альфа в лечении больных ревматоидным артритом Тактика при различных вариантах течения заболеванияThe place of tumor necrosis factor alpha inhibitors in the treatment of rheumatoid arthritis patients: tactics in different variants of the diseaseЧичасоваН. В.ChichasovaN. V.noemail@neicon.ruИнститут профессионального образования Первого Московского государственного медицинского университета им. И.М. СеченоваРоссияthe First Moscow State Medical University named after I.M. SechenovRussian Federation20153012201505106111Copyright © Чичасова Н.В., 20152015Чичасова Н.В.Chichasova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/180

С увеличением продолжительности использования генно-инженерных биологических препаратов (ГИБП) в реальной клинической практике перед клиницистами возникают новые вопросы: как переходить с одного ГИБП на другой при первичной или вторичной неэффективности, непереносимости предшествующей терапии ГИБП, какова тактика при достижении низкой активности заболевания или ремиссии. В настоящей статье освещаются накопленные за последние годы данные, имеющие значение для практикующих врачей.

As the period of use of genetically engineered biologic drugs (GEBD) in clinical practice is growing, clinicians are faced with new questions: how to switch from one GEBD to another in case of primary or secondary inefficacy, intolerance to previous GEBD therapy; what should be done after low disease activity or remission is achieved. The article highlights the recent findings that are relevant for healthcare practitioners.

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The authors declare that there are no conflicts of interest present.