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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2017-5-178-185</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-1811</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Практика</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Practice</subject></subj-group></article-categories><title-group><article-title>ГИДРОЛИЗАТЫ  ПЛАЦЕНТЫ ЧЕЛОВЕКА В РЕКОНСТРУКТИВНОЙ ТЕРАПИИ СОЕДИНИТЕЛЬНОЙ ТКАНИ ХРЯЩА И СУСТАВОВ</article-title><trans-title-group xml:lang="en"><trans-title>HUMAN PLACENTA HYDROLYZATES IN RECONSTRUCTIVE THERAPY OF CONNECTIVE TISSUE OF CARTILAGE AND JOINTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Громова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gromova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Торшин</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Torshin</surname><given-names>I. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат физико-математических наук.</p><p>Долгопрудный</p></bio><bio xml:lang="en"><p>Mathematics Physics PhD</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Диброва</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dibrova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат экономических науке.</p><p>Москва</p></bio><bio xml:lang="en"><p>PhD in Economics.</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гилельс</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gilel’s</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Долгопрудный</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демидов</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Demidov</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ивановская государственная медицинская академия Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ivanovo State Medical Academy of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Московский физико-технический  институт (государственный университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Institute of Physics and Technology (State University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Медицинская корпорация  RHANA</institution><country>Россия</country></aff><aff xml:lang="en"><institution>RHANA</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Ивановская государственная медицинская академия Минздрава России; Московский физико-технический  институт (государственный университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ivanovo State Medical Academy of the Ministry of Healthcare of the Russian Federation; Moscow Institute of Physics and Technology (State University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>11</day><month>05</month><year>2017</year></pub-date><volume>0</volume><issue>5</issue><fpage>178</fpage><lpage>185</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Громова О.А., Торшин И.Ю., Диброва Е.А., Гилельс А.В., Демидов В.И., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Громова О.А., Торшин И.Ю., Диброва Е.А., Гилельс А.В., Демидов В.И.</copyright-holder><copyright-holder xml:lang="en">Gromova O.A., Torshin I.Y., Dibrova E.A., Gilel’s A.V., Demidov V.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/1811">https://www.med-sovet.pro/jour/article/view/1811</self-uri><abstract><p>Одним из перспективных направлений клинического применения препаратов на основе гидролизатов плаценты человека (ГПЧ)   является лечение  ревматоидного   артрита. Показано, что пептидные  компоненты   ГПЧ  могут способствовать существенному ускорению восстановления   соединительной   ткани  за счет противовоспалительного и трофического действия. Представлены   результаты экспериментальных   исследований  препаратов  на основе ГПЧ  для терапии моделей артрита. Рассмотрены перспективы клинического применения препаратов ГПЧ для лечения артрита.</p></abstract><trans-abstract xml:lang="en"><p>Treatment of rheumatoid arthritis is one of the promising directions for the clinical application of human placenta hydrolysates (HPH). HPH peptide components can contribute to a significant acceleration of recovery of connective tissue due to antiinflammatory and trophic effects. The results of experimental studies of HPH-containing medications for the treatment of arthritis models are presented. The prospects  for clinical applications  of HPH-containing preparations for the treatment of arthritis are discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ревматоидный артрит</kwd><kwd>остеоартроз</kwd><kwd>пептиды</kwd><kwd>регенеративная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rheumatoid arthritis</kwd><kwd>osteoarthritis</kwd><kwd>peptides</kwd><kwd>regenerative therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Филатов В.П. Тканевая терапия (учение о биогенных стимуляторах). (изд. третье, дополн.). М.: Знание, 1955. 63 с.</mixed-citation><mixed-citation xml:lang="en">Филатов В.П. Тканевая терапия (учение о биогенных стимуляторах). (изд. третье, дополн.). М.: Знание, 1955. 63 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Beyssac I, Martini MC, Cotte J. Oestrogen identification and dosage in filatov human placenta extracts by high performance liquid chromatography. Int J Cosmet Sci, 1986, 8(4): 175-188.</mixed-citation><mixed-citation xml:lang="en">Beyssac I, Martini MC, Cotte J. Oestrogen identification and dosage in filatov human placenta extracts by high performance liquid chromatography. Int J Cosmet Sci, 1986, 8(4): 175-188.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Han M, Sung YK, Cho SK, Kim D, Won S, Choi CB, Bang SY, Cha HS, Choe JY, Chung WT, Hong SJ, Jun JB, Jung YO, Kim SK, Kim TH, Koh E, Lee HS, Lee J, Lee JH, Lee SS, Nah SS, Shim SC, Yoo DH, Yoo WH, Yoon BY, Jee SH, Bae SC. Factors Associated with the Use of Complementary and Alternative Medicine for Korean Patients with Rheumatoid Arthritis. J Rheumatol, 2015, 42(11): 2075-81.</mixed-citation><mixed-citation xml:lang="en">Han M, Sung YK, Cho SK, Kim D, Won S, Choi CB, Bang SY, Cha HS, Choe JY, Chung WT, Hong SJ, Jun JB, Jung YO, Kim SK, Kim TH, Koh E, Lee HS, Lee J, Lee JH, Lee SS, Nah SS, Shim SC, Yoo DH, Yoo WH, Yoon BY, Jee SH, Bae SC. Factors Associated with the Use of Complementary and Alternative Medicine for Korean Patients with Rheumatoid Arthritis. J Rheumatol, 2015, 42(11): 2075-81.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Gold-Aubert P, Chaumontet M, Capt M. An experimental study of the anti-inflammatory and antiarthritic properties of a standardized placental extract. Int J Tissue React, 1981, 3(3-4): 155-165.</mixed-citation><mixed-citation xml:lang="en">Gold-Aubert P, Chaumontet M, Capt M. An experimental study of the anti-inflammatory and antiarthritic properties of a standardized placental extract. Int J Tissue React, 1981, 3(3-4): 155-165.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Zorn BL Jr. Effect of placental extracts on experimental formaldehyde arthritis in albino rats. Z Gesamte Inn Med, 1955, 10(21): 1009-1012.</mixed-citation><mixed-citation xml:lang="en">Zorn BL Jr. Effect of placental extracts on experimental formaldehyde arthritis in albino rats. Z Gesamte Inn Med, 1955, 10(21): 1009-1012.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Traut EF. Placental extract effective in arthritis. IMJ Ill Med J, 1969, 135(1): 5-8.</mixed-citation><mixed-citation xml:lang="en">Traut EF. Placental extract effective in arthritis. IMJ Ill Med J, 1969, 135(1): 5-8.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Colinet E, Bolcke R. Treatment of chronic evolutive polyarthritis by lyophilized placental extracts. Acta Physiother Rheumatol Belg, 1952, 7(4): 247-250.</mixed-citation><mixed-citation xml:lang="en">Colinet E, Bolcke R. Treatment of chronic evolutive polyarthritis by lyophilized placental extracts. Acta Physiother Rheumatol Belg, 1952, 7(4): 247-250.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rogers BJ, Chang L, Yanagimachi R. Glucose effect on respiration: possible mechanism for capacitation in guinea pig spermatozoa. J Exp Zool, 1979, 207(1): 107-112.</mixed-citation><mixed-citation xml:lang="en">Rogers BJ, Chang L, Yanagimachi R. Glucose effect on respiration: possible mechanism for capacitation in guinea pig spermatozoa. J Exp Zool, 1979, 207(1): 107-112.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kim JK, Kim TH, Park SW, Kim HY, Kim S, Lee S, Lee SM. Protective effects of human placenta extract on cartilage degradation in experimental osteoarthritis. Biol Pharm Bull, 2010, 33(6): 1004-1010.</mixed-citation><mixed-citation xml:lang="en">Kim JK, Kim TH, Park SW, Kim HY, Kim S, Lee S, Lee SM. Protective effects of human placenta extract on cartilage degradation in experimental osteoarthritis. Biol Pharm Bull, 2010, 33(6): 1004-1010.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Biswas TK, Auddy B, Bhattacharya NP, Bhattacharya S, Mukherjee B. Wound healing activity of human placental extracts in rats. Acta Pharmacol Sin, 2001, 22(12): 1113-1116.</mixed-citation><mixed-citation xml:lang="en">Biswas TK, Auddy B, Bhattacharya NP, Bhattacharya S, Mukherjee B. Wound healing activity of human placental extracts in rats. Acta Pharmacol Sin, 2001, 22(12): 1113-1116.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Lee KH, Kim TH, Lee WC, Kim SH, Lee SY, Lee SM. Anti-inflammatory and analgesic effects of human placenta extract. Nat Prod Res, 2011 Jul, 25(11): 1090-1100.</mixed-citation><mixed-citation xml:lang="en">Lee KH, Kim TH, Lee WC, Kim SH, Lee SY, Lee SM. Anti-inflammatory and analgesic effects of human placenta extract. Nat Prod Res, 2011 Jul, 25(11): 1090-1100.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Hong JW, Lee WJ, Hahn SB, Kim BJ, Lew DH. The effect of human placenta extract in a wound healing model. Ann Plast Surg, 2010, 65(1): 96-100.</mixed-citation><mixed-citation xml:lang="en">Hong JW, Lee WJ, Hahn SB, Kim BJ, Lew DH. The effect of human placenta extract in a wound healing model. Ann Plast Surg, 2010, 65(1): 96-100.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta R, Chattopadhyay D. Glutamate is the chemotaxis-inducing factor in placental extracts. Amino Acids, 2009, 37(2): 359-66.</mixed-citation><mixed-citation xml:lang="en">Gupta R, Chattopadhyay D. Glutamate is the chemotaxis-inducing factor in placental extracts. Amino Acids, 2009, 37(2): 359-66.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Chakraborty PD, Bhattacharyya D, Pal S, Ali N. In vitro induction of nitric oxide by mouse peritoneal macrophages treated with human placental extract. Int Immunopharmacol, 2006, 6(1): 100-7.</mixed-citation><mixed-citation xml:lang="en">Chakraborty PD, Bhattacharyya D, Pal S, Ali N. In vitro induction of nitric oxide by mouse peritoneal macrophages treated with human placental extract. Int Immunopharmacol, 2006, 6(1): 100-7.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Wu J, Wang C, Liu Q, Yang T, Zhang Q, Peng J, Gao Y, Sun H, Kaku T, Liu K. Protective effect of JBP485 on concanavalin A-induced hepatocyte toxicity in primary cultured rat hepatocytes. Eur J Pharmacol, 2008 Jul 28, 589(1-3): 299-305.</mixed-citation><mixed-citation xml:lang="en">Wu J, Wang C, Liu Q, Yang T, Zhang Q, Peng J, Gao Y, Sun H, Kaku T, Liu K. Protective effect of JBP485 on concanavalin A-induced hepatocyte toxicity in primary cultured rat hepatocytes. Eur J Pharmacol, 2008 Jul 28, 589(1-3): 299-305.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Громова О.А., Торшин И.Ю., Сухих Г.Т., Згода В.Г., Баранов И.И., Демидов В.И., Федотова Л.Э., Назаренко О.А. Анализ легкой пептидной фракции Лаеннека методами современной протеомики, Фармакокинетика и фармакодинамика, 2016, 4: 13-17.</mixed-citation><mixed-citation xml:lang="en">Громова О.А., Торшин И.Ю., Сухих Г.Т., Згода В.Г., Баранов И.И., Демидов В.И., Федотова Л.Э., Назаренко О.А. Анализ легкой пептидной фракции Лаеннека методами современной протеомики, Фармакокинетика и фармакодинамика, 2016, 4: 13-17.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Li XM, Ferraro L, Tanganelli S, O’Connor WT, Hasselrot U, Ungerstedt U, Fuxe K. Neurotensin peptides antagonistically regulate postsynaptic dopamine D2 receptors in rat nucleus accumbens: a receptor binding and microdialysis study. J Neural Transm Gen Sect, 1995, 102(2): 125-137.</mixed-citation><mixed-citation xml:lang="en">Li XM, Ferraro L, Tanganelli S, O’Connor WT, Hasselrot U, Ungerstedt U, Fuxe K. Neurotensin peptides antagonistically regulate postsynaptic dopamine D2 receptors in rat nucleus accumbens: a receptor binding and microdialysis study. J Neural Transm Gen Sect, 1995, 102(2): 125-137.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Gendron L, Perron A, Payet MD, Gallo-Payet N, Sarret P, Beaudet A. Low-affinity neurotensin receptor (NTS2) signaling: internalizationdependent activation of extracellular signalregulated kinases 1/2. Mol Pharmacol, 2004, 66(6): 1421-30.</mixed-citation><mixed-citation xml:lang="en">Gendron L, Perron A, Payet MD, Gallo-Payet N, Sarret P, Beaudet A. Low-affinity neurotensin receptor (NTS2) signaling: internalizationdependent activation of extracellular signalregulated kinases 1/2. Mol Pharmacol, 2004, 66(6): 1421-30.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Watkins LR, Milligan ED, Maier SF. Glial activation: a driving force for pathological pain. Trends in Neurosciences. 2001, 24(8): 450–455.</mixed-citation><mixed-citation xml:lang="en">Watkins LR, Milligan ED, Maier SF. Glial activation: a driving force for pathological pain. Trends in Neurosciences. 2001, 24(8): 450–455.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Lee KW, Ji HM, Kim DW, Choi SM, Kim S, Yang EJ. Effects of Hominis placenta on LPS-induced cell toxicity in BV2 microglial cells. J Ethnopharmacol, 2013, 147(2): 286-92.</mixed-citation><mixed-citation xml:lang="en">Lee KW, Ji HM, Kim DW, Choi SM, Kim S, Yang EJ. Effects of Hominis placenta on LPS-induced cell toxicity in BV2 microglial cells. J Ethnopharmacol, 2013, 147(2): 286-92.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Song Y, Bi L, Zhang Z, Huang Z, Hou W, Lu X, Sun P, Han Y. Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury. Mol Med Report, 2012, 5(2): 432-8.</mixed-citation><mixed-citation xml:lang="en">Song Y, Bi L, Zhang Z, Huang Z, Hou W, Lu X, Sun P, Han Y. Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury. Mol Med Report, 2012, 5(2): 432-8.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Leventoglu S, Koksal H, Sancak B, Taneri F, Onuk E. The effect of calcitonin gene-related peptide on healing of intestinal anastomosis in rats with experimental obstructive jaundice. J Hepatobiliary Pancreat Surg, 2009, 16(4): 546-51.</mixed-citation><mixed-citation xml:lang="en">Leventoglu S, Koksal H, Sancak B, Taneri F, Onuk E. The effect of calcitonin gene-related peptide on healing of intestinal anastomosis in rats with experimental obstructive jaundice. J Hepatobiliary Pancreat Surg, 2009, 16(4): 546-51.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lee KH, Kim TH, Lee WC, Kim SH, Lee SY, Lee SM. Anti-inflammatory and analgesic effects of human placenta extract. Nat Prod Res, 2011, 25(11): 1090-100.</mixed-citation><mixed-citation xml:lang="en">Lee KH, Kim TH, Lee WC, Kim SH, Lee SY, Lee SM. Anti-inflammatory and analgesic effects of human placenta extract. Nat Prod Res, 2011, 25(11): 1090-100.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kim JK, Kim TH, Park SW, Kim HY, Kim Sh, Lee Sy, Lee SM. Protective effects of human placenta extract on cartilage degradation in experimental osteoarthritis. Biol Pharm Bull, 2010, 33(6): 1004-1010.</mixed-citation><mixed-citation xml:lang="en">Kim JK, Kim TH, Park SW, Kim HY, Kim Sh, Lee Sy, Lee SM. Protective effects of human placenta extract on cartilage degradation in experimental osteoarthritis. Biol Pharm Bull, 2010, 33(6): 1004-1010.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Yeom MJ, Lee HC, Kim GH, Shim I, Lee HJ, Hahm DH. Therapeutic effects of Hominis placenta injection into an acupuncture point on the inflammatory responses in subchondral bone region of adjuvant-induced polyarthritic rat. Biol Pharm Bull, 2003, 26(10): 1472-1477.</mixed-citation><mixed-citation xml:lang="en">Yeom MJ, Lee HC, Kim GH, Shim I, Lee HJ, Hahm DH. Therapeutic effects of Hominis placenta injection into an acupuncture point on the inflammatory responses in subchondral bone region of adjuvant-induced polyarthritic rat. Biol Pharm Bull, 2003, 26(10): 1472-1477.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Bartlett RR, Schleyerbach R. Immunopharmacological profile of a novel isoxazol derivative, HWA 486, with potential antirheumatic activity– I. Disease modifying action on adjuvant arthritis of the rat. Int. J. Immunopharmacol., 1985, 7: 7-18.</mixed-citation><mixed-citation xml:lang="en">Bartlett RR, Schleyerbach R. Immunopharmacological profile of a novel isoxazol derivative, HWA 486, with potential antirheumatic activity– I. Disease modifying action on adjuvant arthritis of the rat. Int. J. Immunopharmacol., 1985, 7: 7-18.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Blackham A, Burns JW, Farmer JB et al. An X-ray analysis of adjuvant arthritis in the rat. The effect of prednisolone and indomethacin. Agents Actions, 1977, 7: 145-151.</mixed-citation><mixed-citation xml:lang="en">Blackham A, Burns JW, Farmer JB et al. An X-ray analysis of adjuvant arthritis in the rat. The effect of prednisolone and indomethacin. Agents Actions, 1977, 7: 145-151.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Fitzpatrick LR, Green C, Frauenhoffer EE et al. Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase. Inflammopharmacology, 2011, 19: 75-87.</mixed-citation><mixed-citation xml:lang="en">Fitzpatrick LR, Green C, Frauenhoffer EE et al. Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase. Inflammopharmacology, 2011, 19: 75-87.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Chang TK, Huang CH, Huang CH et al. The influence of long-term treadmill exercise on bone mass and articular cartilage in ovariectomized rats. BMC Musculoskelet Disord, 2010, 11: 185.</mixed-citation><mixed-citation xml:lang="en">Chang TK, Huang CH, Huang CH et al. The influence of long-term treadmill exercise on bone mass and articular cartilage in ovariectomized rats. BMC Musculoskelet Disord, 2010, 11: 185.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Кашкин В.А., Шекунова Е.В., Мужикян А.А., Макарова М.Н., Макаров В.Г. Комплексная оценка степени развития патологии при моделировании адъювант-индуцированного артрита у крыс. Международный вестник ветеринарии, 2015, 1: 92-103.</mixed-citation><mixed-citation xml:lang="en">Кашкин В.А., Шекунова Е.В., Мужикян А.А., Макарова М.Н., Макаров В.Г. Комплексная оценка степени развития патологии при моделировании адъювант-индуцированного артрита у крыс. Международный вестник ветеринарии, 2015, 1: 92-103.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Verhaeghe A, Lebeurre R, Lesage R, Minne A. 1st rhematological trials of intra-articular injections of placental extracts. Lille Med, 1961, 6: 244-245.</mixed-citation><mixed-citation xml:lang="en">Verhaeghe A, Lebeurre R, Lesage R, Minne A. 1st rhematological trials of intra-articular injections of placental extracts. Lille Med, 1961, 6: 244-245.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Meixner HK. Effects of percutaneously applied placenta extracts in chronic rheumatism and arthrosis. Medizinische, 1955, 31-32: 1091-1093.</mixed-citation><mixed-citation xml:lang="en">Meixner HK. Effects of percutaneously applied placenta extracts in chronic rheumatism and arthrosis. Medizinische, 1955, 31-32: 1091-1093.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Dillon RN, Majnarich JJ. Placental extract in treatment of rheumatoid arthritis. Northwest Med, 1951, 50(9): 677-679.</mixed-citation><mixed-citation xml:lang="en">Dillon RN, Majnarich JJ. Placental extract in treatment of rheumatoid arthritis. Northwest Med, 1951, 50(9): 677-679.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Lintz RM. Implantation of placental tissue in patients with rheumatoid arthritis; preliminary report. Ann Rheum Dis, 1954 Mar, 13(1): 63-6.</mixed-citation><mixed-citation xml:lang="en">Lintz RM. Implantation of placental tissue in patients with rheumatoid arthritis; preliminary report. Ann Rheum Dis, 1954 Mar, 13(1): 63-6.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Cho TH, Park KM. Complex regional pain syndrome type 1 relieved by acupuncture point injections with placental extract. J Acupunct Meridian Stud, 2014, 7(3): 155-8.</mixed-citation><mixed-citation xml:lang="en">Cho TH, Park KM. Complex regional pain syndrome type 1 relieved by acupuncture point injections with placental extract. J Acupunct Meridian Stud, 2014, 7(3): 155-8.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
