<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2015-5-124-128</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-182</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДИССЕРТАНТ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DISSERTANT</subject></subj-group></article-categories><title-group><article-title>Ассоциированные симптомы у больных СРК</article-title><trans-title-group xml:lang="en"><trans-title>Associated symptoms in patients with IBS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тащян</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Taschyan</surname><given-names>O. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мнацаканян</surname><given-names>М. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Mnatsakanyan</surname><given-names>M. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Погромов</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Pogromov</surname><given-names>A. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дюкова</surname><given-names>Г. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Dyukova</surname><given-names>G. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Халяпина</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Khalyapina</surname><given-names>D. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозова</surname><given-names>Ю. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozova</surname><given-names>Y. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Первый Московский государственный медицинский университет им. И.М. Сеченова<country>Россия</country></aff><aff xml:lang="en">the First Moscow State Medical University named after I.M. Sechenov<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2015</year></pub-date><volume>0</volume><issue>5</issue><fpage>124</fpage><lpage>128</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Тащян О.В., Мнацаканян М.Г., Погромов А.П., Дюкова Г.М., Халяпина Д.В., Морозова Ю.Н., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Тащян О.В., Мнацаканян М.Г., Погромов А.П., Дюкова Г.М., Халяпина Д.В., Морозова Ю.Н.</copyright-holder><copyright-holder xml:lang="en">Taschyan O.V., Mnatsakanyan M.G., Pogromov A.P., Dyukova G.M., Khalyapina D.V., Morozova Y.N.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/182">https://www.med-sovet.pro/jour/article/view/182</self-uri><abstract><p>У 125 больных СРК в возрасте от 19 до 45 лет исследованы частота и клинический спектр внекишечных ассоциированных симптомов с помощью анкеты соматизированных расстройств (SOMS_2). Результаты исследования показали высокую частоту встречаемости ассоциированных симптомов. Более чем у 40% исследованных больных на одного пациента приходилось от 16 до 25 негастроэнтерологических симптомов. Чаще всего ассоциированные симптомы проявлялись в виде болей в разных частях тела. Кроме того, наблюдались разнообразные вегетативные и нейро-эндокринно-мотивационные расстройства. Более половины больных отмечали повышенную утомляемость. У женщин, по сравнению с мужчинами, достоверно чаще встречались такие симптомы, как одышка, обморочные состояния, ощущение приливов холода и тепла, расплывчатость зрения, чувство жжения в промежности, боли при половом акте и равнодушие к сексу. Мужчины достоверно чаще, чем женщины, жаловались на боли в грудной клетке. Анализ в зависимости от типа СРК показал преобладание запорного варианта у женщин и диарейного у мужчин. При диарейном варианте СРК при сравнении с другими подгруппами отмечено статистически значимое преобладание затруднений при глотании, снижение аппетита, а также дрожание и чувство внутренней дрожи. Полученные в исследовании данные позволяют внести дополнительные аргументы в биопсихосоциальную модель СРК, однако для уточнения специфичности выявленных фактов необходимо сопоставление внекишечных симптомов больных СРК с таковыми в контроле и при органических моделях (воспалительные заболевания кишечника).</p></abstract><trans-abstract xml:lang="en"><p>Summary. We examined the frequency and clinical variety of associated extraintestinal symptoms in 125 IBS patients within the age of 19 - 45 years by using SOMS-2. There was a high prevalence of associated symptoms in IBS patients group. More then 40% of examined patients have had from 16 to 25 nongastroenterologic symptoms in one patient. The most frequent associated symptoms were varied types of pains in different parts of body. Furthermore different vegetative and neuro-endocrine-motivational disorders were observed. More than half of patients in the study reported increased fatigability. Women reported “dyspnoe”, “syncope’s”, “rushes”, “visual fuzziness”, “sense of burning in perineum”, “dyspareunia” and “indifference in sexual life” statistically significant more often then men. Men reported “chest pain” statically significant more often then women. Correlation analysis revealed the predominance of constipation type of IBS in women and diarrhea-type of IBS (IBS-D) in men. In patients with IBS-D type there were statistically significant predominance of “swallowing discomfort”, “poor appetite” and “sence of inner trembling”. The results of the study allow to enter additional arguments in biopsychosocial model of IBS. Nevertheless, it is necessary to compare extraintestinal symptoms in IBS patients with those in healthy control group and in IBD patients to specify these factors.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром раздраженного кишечника</kwd><kwd>возраст</kwd><kwd>пол</kwd><kwd>ассоциированные симптомы</kwd><kwd>irritable bowel syndrome</kwd><kwd>associated symptoms</kwd><kwd>age</kwd><kwd>gender</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Barbara G, Cremon C, Carini G et aL. The immune system in irritable boweL syndrome. J Neurogastroenterol Motil, 2011, 17: 349-59.</mixed-citation><mixed-citation xml:lang="en">Barbara G, Cremon C, Carini G et aL. The immune system in irritable boweL syndrome. J Neurogastroenterol Motil, 2011, 17: 349-59.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">ChiaL HJ, CamiLLeri M. Gender differences in irritable boweL syndrome. J Gend Specif Med, 2002, 5: 37-45.</mixed-citation><mixed-citation xml:lang="en">ChiaL HJ, CamiLLeri M. Gender differences in irritable boweL syndrome. J Gend Specif Med, 2002, 5: 37-45.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Drossman D. Abuse, Trauma, and GI ILLness: Is There a Link? Am J Gastroenterol, 2011, 106: 14-25;</mixed-citation><mixed-citation xml:lang="en">Drossman D. Abuse, Trauma, and GI ILLness: Is There a Link? Am J Gastroenterol, 2011, 106: 14-25;</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Drossman DA, Whitehead WE, CamiLLeri M. IrritabLe boweL syndrome: a technicaLreview for practice guideLine deveLopment. Gastroenterology, 1997, 112: 2120-2137.</mixed-citation><mixed-citation xml:lang="en">Drossman DA, Whitehead WE, CamiLLeri M. IrritabLe boweL syndrome: a technicaLreview for practice guideLine deveLopment. Gastroenterology, 1997, 112: 2120-2137.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Drossman DA. The functionaL gastrointestinaL disorders and the Rome process. Gastroenterology, 2006, 130: 1377-1390.</mixed-citation><mixed-citation xml:lang="en">Drossman DA. The functionaL gastrointestinaL disorders and the Rome process. Gastroenterology, 2006, 130: 1377-1390.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Fink P. The use of hospitaLizations by persistent somatizing patients. Psychol Med, 1992, 22: 173-80.</mixed-citation><mixed-citation xml:lang="en">Fink P. The use of hospitaLizations by persistent somatizing patients. Psychol Med, 1992, 22: 173-80.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Herman J, Pokkunuri V, Braham L, PimenteL M. Gender distribution in irritabLe boweL syndrome is proportionaL to the severity of constipation reLative to diarrhea. Gend Med, 2010, 7: 240-246.</mixed-citation><mixed-citation xml:lang="en">Herman J, Pokkunuri V, Braham L, PimenteL M. Gender distribution in irritabLe boweL syndrome is proportionaL to the severity of constipation reLative to diarrhea. Gend Med, 2010, 7: 240-246.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">HershfieLd HYPERLINK "http//www.ncbi.nLm. nih.gov/pubmed?term=%22HershfieLd%20 NB%22%5BAuthor%5D" NB NongastrointestinaL symptoms of irritabLe boweL syndrome: an office-based cLinicaL survey. Can J HYPERLINK "javascript:AL_get(this,%20'jour',%20'Can%20 J%20GastroenteroL.');"GastroenteroLHYPERLINK "javascript:AL_get(this,%20'jour',%20'Can%20 J%20GastroenteroL.');". 2005 Apr;19(4):231-4.</mixed-citation><mixed-citation xml:lang="en">HershfieLd HYPERLINK "http//www.ncbi.nLm. nih.gov/pubmed?term=%22HershfieLd%20 NB%22%5BAuthor%5D" NB NongastrointestinaL symptoms of irritabLe boweL syndrome: an office-based cLinicaL survey. Can J HYPERLINK "javascript:AL_get(this,%20'jour',%20'Can%20 J%20GastroenteroL.');"GastroenteroLHYPERLINK "javascript:AL_get(this,%20'jour',%20'Can%20 J%20GastroenteroL.');". 2005 Apr;19(4):231-4.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kim SE, Chang L. OverLap between functional GI disorders and other functionaL syndromes: what are the underLying mechanisms? NeurogastroenteroL MotiL (2012) doi: 10.1111/ j.1365-2982.2012.01993.</mixed-citation><mixed-citation xml:lang="en">Kim SE, Chang L. OverLap between functional GI disorders and other functionaL syndromes: what are the underLying mechanisms? NeurogastroenteroL MotiL (2012) doi: 10.1111/ j.1365-2982.2012.01993.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">MataLon A, KotLiroff A, BLumberg Gari, Yaphe J. Kitai E. Non-specific symptoms as cLues to changes in emotionaL weLL-being. BMC Family Practice, 2011, 12: 77.</mixed-citation><mixed-citation xml:lang="en">MataLon A, KotLiroff A, BLumberg Gari, Yaphe J. Kitai E. Non-specific symptoms as cLues to changes in emotionaL weLL-being. BMC Family Practice, 2011, 12: 77.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mayer EA, TiLLisch K. The brain-gut axis in abdominaL pain syndromes. Annu Rev Med, 2011, 62: 381-96.</mixed-citation><mixed-citation xml:lang="en">Mayer EA, TiLLisch K. The brain-gut axis in abdominaL pain syndromes. Annu Rev Med, 2011, 62: 381-96.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">MeLeine M, Matricon J. Gender-reLated differences in irritabLe boweL syndrome: PotentiaL mechanisms of sex hormones. World J Gastroenterol, 2014, 20(22): 6725-6743.</mixed-citation><mixed-citation xml:lang="en">MeLeine M, Matricon J. Gender-reLated differences in irritabLe boweL syndrome: PotentiaL mechanisms of sex hormones. World J Gastroenterol, 2014, 20(22): 6725-6743.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">MuLak A, Tache Y, Larauche M. Sex hormones in the moduLation of irritabLe boweL syndrome. World J Gastroenterol, 2014, 20(10): 2433-2448.</mixed-citation><mixed-citation xml:lang="en">MuLak A, Tache Y, Larauche M. Sex hormones in the moduLation of irritabLe boweL syndrome. World J Gastroenterol, 2014, 20(10): 2433-2448.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Multi-Dimensional Clinical Profile (MDCP): For the Functional Gastrointestinal Disorders 1-st edition. Ed. DROSSMAN D.A. et aL. 2015.</mixed-citation><mixed-citation xml:lang="en">Multi-Dimensional Clinical Profile (MDCP): For the Functional Gastrointestinal Disorders 1-st edition. Ed. DROSSMAN D.A. et aL. 2015.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">PimenteL M. The prevaLence of smaLL intestinaL bacteriaL overgrowth in irritabLe boweL syndrome: IBS vs heaLthy controLs (not historicaL definitions). Gut, 2008, 57: 1334-5.</mixed-citation><mixed-citation xml:lang="en">PimenteL M. The prevaLence of smaLL intestinaL bacteriaL overgrowth in irritabLe boweL syndrome: IBS vs heaLthy controLs (not historicaL definitions). Gut, 2008, 57: 1334-5.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
