medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-8-112-115medsovet-1837Research ArticleШкола оториноларингологаSchool otorhinolaryngologyМЕДИКАМЕНТОЗНЫЙ РИНИТ ВОПРОСЫ И ОТВЕТЫDRUG-INDUCED RHINITIS: QUESTIONS AND ANSWERSШиленковаВ. В.ShelenkovaV. V.

Доктор медицинских наук,  профессор

MD, Prof.

Ярославский государственный медицинский университетРоссияYaroslavl State Medical UniversityRussian Federation20171205201708112115Copyright © Шиленкова В.В., 20172017Шиленкова В.В.Shelenkova V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/1837

Медикаментозный  ринит (МР) развивается в результате длительного приема топических деконгестантов и различных лекарственных препаратов системного действия. В статье представлен обзор литературных данных, освещающих вопросы патогенеза, клиники, диагностики  и лечения заболевания. Подчеркнуто, что в настоящее время интраназальные глюкокортикостероиды  являются единственными  препаратами, эффективность которых при МР доказана в рандомизированных контролируемых клинических исследованиях. Авторы приводят собственные  наблюдения  применения мометазона фуроата у 16 больных с МР в течение 4 недель при режиме дозирования 400  мкг/сут. 12 пациентов (75%) смогли полностью отказаться от приема деконгестантов к концу второй недели лечения. В одном случае имел место рецидив заболевания. Топические стероиды позволяют облегчить пациенту период отказа от топических сосудосуживающих препаратов. Тем не менее больные должны быть предупреждены о возможности рецидива МР в случаях повторного бесконтрольного использования деконгестантов.

Drug-induced rhinitis (DIR) develops as a result of long-term use of topical decongestants and different drugs of systemic action. The article presents a review of the literature covering the issues of pathogenesis, clinic, diagnostics and treatment of the disease. It is stressed that currently intranasal glucocorticosteroids are the only drugs effectiveness  of which for drug-induced rhinitis is proved in randomized controlled clinical trials. The authors provide observations of the use of mometasone furoate in 16 patients with DIR for 4 weeks at a dosing of 400 mg/day. 12 patients (75%) were able to completely stop taking decongestants to the end of the second week of treatment. In one case there was recurrence of the disease.

Topical steroids help to alleviate the patient’s period of withdrawal from topical vasoconstrictor preparations. However, patients should be warned about the possibility of recurrence of DIR in cases of repeated uncontrolled use of decongestants.

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The authors declare that there are no conflicts of interest present.