medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-4-19-23medsovet-1846Research ArticleИнфекции в педиатрииPediatric iectionsРОТАВИРУСНАЯ ИНФЕКЦИЯ У ДЕТЕЙ В РФ: ПРОБЛЕМЫ ДИАГНОСТИКИ И ТАКТИКИ ТЕРАПИИ В СОВРЕМЕННЫХ УСЛОВИЯХROTAVIRUS INFECTION IN CHILDREN IN THE RF: DIAGNOSTIC AND TREATMENT CHALLENGES TODAYБЕХТЕРЕВАМ. К.BECHTEREVAM. K.

к.м.н.

PhD in medicine

КОМАРОВАА. М.KOMAROVAA. M.УСКОВА. Н.USKOVA. N.

д.м.н.

MD

Детский научно-клинический центр инфекционных болезней Федерального медико-биологического агентства РоссииРоссияFederal State-Financed Institution Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency (PRCCID)Russian Federation201726052017041923Copyright © БЕХТЕРЕВА М.К., КОМАРОВА А.М., УСКОВ А.Н., 20172017БЕХТЕРЕВА М.К., КОМАРОВА А.М., УСКОВ А.Н.BECHTEREVA M.K., KOMAROVA A.M., USKOV A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/1846

Острые инфекционные диареи у детей во всем мире являются актуальной проблемой здравоохранения [1]. В 2015 г. показатель заболеваемости острыми кишечными инфекциями (ОКИ) в Российской Федерации составил 545,89 на 100 тыс. населения, что практически не отличается от показателя 2014 г. При этом на долю ОКИ неустановленной этиологии приходится 63,44% случаев. Сохраняются выраженные различия в эффективности этиологической диагностики ОКИ на различных территориях Российской Федерации. Наряду со снижением заболеваемости по отдельным нозологиям, отмечался рост заболеваемости кампилобактериозом — на 30,3%, ротавирусной — на 14% и норовирусной — на 26,4% инфекциями [2].

Acute infectious diarrhea in children is a global healthcare challenge [1]. In 2015, the incidence of acute intestinal infections (AII) in the Russian Federation amounted to 545.89 per 100 thousand people; that is almost exactly the same as in 2014. AII of unknown etiology account for 63.44% of cases. There are still significant differences in the effectiveness of the etiological diagnosis of AII in different areas of the Russian Federation. Along with a reduction in the incidence of separate nosologies, the incidence of campylobacteriosis increased by 30.3%, rotavirus by 14% and norovirus by 26.4% [2].

детиострые кишечные инфекцииэтиологиятерапияchildrenacute intestinal infectionsetiologytherapyReferencesGuarino A, Albano F, Ashkenazi S, Gendrel D, Hoekstra JH, Shamir R, Szajewska H. European Society for Paediatric Gastroenterology, Hepatology, and Nutrition / European Society for Paediatric Infectious Diseases Evidence-based Guidelines for the Management of Acute Gastroenteritis in Children in Europe. J Pediat Gastroenterol Nutr, 2008 May, 46(Suppl. 2): 81-122.Guarino A, Albano F, Ashkenazi S, Gendrel D, Hoekstra JH, Shamir R, Szajewska H. European Society for Paediatric Gastroenterology, Hepatology, and Nutrition / European Society for Paediatric Infectious Diseases Evidence-based Guidelines for the Management of Acute Gastroenteritis in Children in Europe. J Pediat Gastroenterol Nutr, 2008 May, 46(Suppl. 2): 81-122.Государственный доклад. М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека, 2016. 99 с.Государственный доклад. М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека, 2016. 99 с.Lobzin YV, Kharit SM, Goveia MG, O’Brian MA, Podkolzin AT, Blokhin BM, Bekhtereva MK, Rudakova AV, Tikunova NV. Burden of Childhood Rotavirus Disease in the Outpatient Setting of the Russian Federation. Pediatr Infect Dis J, 2016 Dec 15. doi: 10.1097/INF.000000000000147.Lobzin YV, Kharit SM, Goveia MG, O’Brian MA, Podkolzin AT, Blokhin BM, Bekhtereva MK, Rudakova AV, Tikunova NV. Burden of Childhood Rotavirus Disease in the Outpatient Setting of the Russian Federation. Pediatr Infect Dis J, 2016 Dec 15. doi: 10.1097/INF.000000000000147.Плоскирева А.А. Острые кишечные инфекции вирусной этиологии у детей: клиника, диагностика и терапия. Автореферат дисс. д.м.н. Москва. 2016. 49 с.Плоскирева А.А. Острые кишечные инфекции вирусной этиологии у детей: клиника, диагностика и терапия. Автореферат дисс. д.м.н. Москва. 2016. 49 с.Ruuska T, Vesikari T. Rotavirus disease in Finnish children: use of numerical scores for clinical severity of diarrhoeal episodes. Scand J Infect Dis, 1990, 22: 259-67.Ruuska T, Vesikari T. Rotavirus disease in Finnish children: use of numerical scores for clinical severity of diarrhoeal episodes. Scand J Infect Dis, 1990, 22: 259-67.СП 3.1.1.3108-13 «Профилактика острых кишечных инфекций».СП 3.1.1.3108-13 «Профилактика острых кишечных инфекций».Acute diarrhea in adults and children: a global perspective. World Gastroenterology Organisation Global Guidelines. February 2012. 24 р.Acute diarrhea in adults and children: a global perspective. World Gastroenterology Organisation Global Guidelines. February 2012. 24 р.Guarino A, Ashkenazi Sh, Gendrel D et al. European Society for Paediatric Gastroenterology, Hepatology, and Nutrition / European Society for Paediatric Infectious Diseases Evidence-based Guidelines for the Management of Acute Gastroenteritis in Children in Europe: Update 2014. JPGN, 2014 July, 59(1): 132-152.Guarino A, Ashkenazi Sh, Gendrel D et al. European Society for Paediatric Gastroenterology, Hepatology, and Nutrition / European Society for Paediatric Infectious Diseases Evidence-based Guidelines for the Management of Acute Gastroenteritis in Children in Europe: Update 2014. JPGN, 2014 July, 59(1): 132-152.Острые кишечные инфекции у детей. Учебно-методическое пособие. Под ред. Учайкина В.Ф. Москва. ГОУ ВПО РГМУ. 2005. 116 с.Острые кишечные инфекции у детей. Учебно-методическое пособие. Под ред. Учайкина В.Ф. Москва. ГОУ ВПО РГМУ. 2005. 116 с.Bellemare S, Hartling L, Wiebe N et al. Oral rehydration versus intravenous therapy for treating dehydration due to gastroenteritis in children: a meta-analysis of randomised controlled trials. BMC Medicine, 2004, 2: 11.Bellemare S, Hartling L, Wiebe N et al. Oral rehydration versus intravenous therapy for treating dehydration due to gastroenteritis in children: a meta-analysis of randomised controlled trials. BMC Medicine, 2004, 2: 11.Fonseca BK, Holdgate A, Craig JC. Enteral vs intravenous rehydration therapy for children with gastroenteritis: a meta-analysis of randomized controlled trials. Arch Pediatr Adolesc Med, 2004, 158(5): 483-90.Fonseca BK, Holdgate A, Craig JC. Enteral vs intravenous rehydration therapy for children with gastroenteritis: a meta-analysis of randomized controlled trials. Arch Pediatr Adolesc Med, 2004, 158(5): 483-90.Szajewska H, Guarino A, Hojsak I, Indrio F, Kolacek S, Shamir R, Vandenplas Y, Weizman Z. Working Group for Probiotics and Prebiotics /on Behalf of the ESPGHAN Working Group for Probiotics and Prebiotics Use of Probiotics for Management of Acute Gastroenteritis: A Position Paper by the ESPGHAN. JPGN, 2014 April, 58(4): 531-9. doi: 10.1097/MPG.0000000000000320.Szajewska H, Guarino A, Hojsak I, Indrio F, Kolacek S, Shamir R, Vandenplas Y, Weizman Z. Working Group for Probiotics and Prebiotics /on Behalf of the ESPGHAN Working Group for Probiotics and Prebiotics Use of Probiotics for Management of Acute Gastroenteritis: A Position Paper by the ESPGHAN. JPGN, 2014 April, 58(4): 531-9. doi: 10.1097/MPG.0000000000000320.Allen S, Martinez E, Gregorio G et al. Probiotics for treating acute infectious diarrhoea (Review), 2010 The Cochrane Collaboration. Published by JohnWiley & Sons, Ltd. http://www.thecochranelibrary.com.Allen S, Martinez E, Gregorio G et al. Probiotics for treating acute infectious diarrhoea (Review), 2010 The Cochrane Collaboration. Published by JohnWiley & Sons, Ltd. http://www.thecochranelibrary.com.West NP, Pyne DB, Peake JM, Cripps AW. Probiotics, immunity and exercise: a review. Exerc Immunol Rev, 2009; 15: 107-26.West NP, Pyne DB, Peake JM, Cripps AW. Probiotics, immunity and exercise: a review. Exerc Immunol Rev, 2009; 15: 107-26.Szajewska H. Advances and limitations of evidence-based medicine — impact for probiotics. Ann Nutr Metab, 2010, 57(Suppl.): 6-9.Szajewska H. Advances and limitations of evidence-based medicine — impact for probiotics. Ann Nutr Metab, 2010, 57(Suppl.): 6-9.Weizman Z. Probiotics Use in Childhood Acute Diarrhea: A Web-based Survey. Journal of Clinical Gastroenterology, 2011 May-June, 45(5): 426-428.Weizman Z. Probiotics Use in Childhood Acute Diarrhea: A Web-based Survey. Journal of Clinical Gastroenterology, 2011 May-June, 45(5): 426-428.Best evidence statement (BESt). Use of Lactobacillus rhamnosus GG in children with acute gastroenteritis.http://www.guidelines.gov/content.aspx?id=33576&search=acute+diarrhea.Best evidence statement (BESt). Use of Lactobacillus rhamnosus GG in children with acute gastroenteritis.http://www.guidelines.gov/content.aspx?id=33576&search=acute+diarrhea.Tao Y, Drabik KA, Waypa TS, Musch MW, Alverdy JC, Schneewind O, Chang EB, Petrof EO. Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells. Am J Physiol Cell Physiol, 2006, 290(4): 1018-30.Tao Y, Drabik KA, Waypa TS, Musch MW, Alverdy JC, Schneewind O, Chang EB, Petrof EO. Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells. Am J Physiol Cell Physiol, 2006, 290(4): 1018-30.Licciardi PV, Tang ML. Vaccine adjuvant properties of probiotic bacteria. Discov Med, 2011, 12(67): 525-33.Licciardi PV, Tang ML. Vaccine adjuvant properties of probiotic bacteria. Discov Med, 2011, 12(67): 525-33.Hojsak I, Snovak N, Abdovi_ S et al. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial. Clin Nutr, 2010, 29(3): 312-6.Hojsak I, Snovak N, Abdovi_ S et al. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial. Clin Nutr, 2010, 29(3): 312-6.Guandalini S, Pensabene L, Zikri M et al. Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial. J Pediatr Gastroenterol Nutr, 2000, 30: 54-60.Guandalini S, Pensabene L, Zikri M et al. Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial. J Pediatr Gastroenterol Nutr, 2000, 30: 54-60.Szajawska HJ. Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. Pediatr, 2001, 138: 361-365.Szajawska HJ. Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. Pediatr, 2001, 138: 361-365.

The authors declare that there are no conflicts of interest present.