medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-4-25-30medsovet-1847Research ArticleГРИПП, ОРВИГРИПП, ОРВИИНГИБИТОРЫ НЕЙРАМИНИДАЗЫ — ЗОЛОТОЙ СТАНДАРТ ПРОТИВОВИРУСНОЙ ТЕРАПИИ ГРИППА ТИПА АNEURAMINIDASE INHIBITORS — THE GOLD STANDARD OF ANTIVIRAL INFLUENZA A THERAPYЦВЕТКОВВ. В.TSVETKOVV. V.

к.м.н.

PhD in medicine

ГОЛОБОКОВГ. С.GOLOBKOVG. S.Научно-исследовательский институт гриппа Минздрава РоссииРоссияScientific and Research Institute of influenza of the Ministry of Health of RussiaRussian Federation201726052017042530Copyright © ЦВЕТКОВ В.В., ГОЛОБОКОВ Г.С., 20172017ЦВЕТКОВ В.В., ГОЛОБОКОВ Г.С.TSVETKOV V.V., GOLOBKOV G.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/1847

Грипп — острая высококонтагиозная респираторная вирусная инфекция, имеющая склонность к эпидемическому распространению, поражению всех возрастных групп населения в различных географических условиях. Большое количество ежегодно регистрируемых случаев тяжелого/осложненного течения гриппа, а также летальных исходов в первую очередь обусловлено высокой заболеваемостью и вовлечением в эпидемический процесс лиц из групп риска неблагоприятного течения болезни. Главной задачей практикующего врача является предупреждение развития тяжелых и осложненных форм гриппа, что может быть достигнуто как за счет ранней диагностики гриппа и верной оценки состояния пациента с учетом признаков прогрессирующего течения заболевания, так и за счет своевременного назначения этиотропной терапии. Противовирусная терапия должна быть назначена в течение 48 часов от появления первых симптомов заболевания всем пациентам с лабораторно подтвержденным диагнозом «грипп», а также больным с подозрением на наличие гриппозной инфекции, имеющим высокий риск развития осложнений независимо от статуса вакцинации против гриппа и независимо от степени тяжести болезни. Циркулирующие в настоящее время на территории Российской Федерации сезонные вирусы гриппа A(H3N2) и A(H1N1)pdm09 характеризуются наличием высокой чувствительности к ингибиторам нейраминидазы — осельтамивиру и занамивиру, что позволяет рекомендовать эти препараты в качестве препаратов первой линии для проведения этиотропной терапии гриппа.

Influenza is an acute highly contagious respiratory viral infection with a propensity for epidemic spread, affecting all age groups in various geographical conditions. A large number of annually registered cases of severe/complicated course of influenza and deaths are primarily due to the high incidence and involvement in the epidemic process of persons at risk of adverse course of the disease. The main task of the practitioner is to prevent development of severe and complicated forms of influenza that can be achieved at the expense of early diagnosis of influenza and correct evaluation of the condition of the patient given the signs of the progressive course of the disease, and by the timely indication of etiotropic therapy. The antiviral therapy should be indicated within 48 hours from the first symptoms of the disease to all patients with laboratory confirmed diagnosis «flu», as well as to patients with suspected influenza infection with a high risk of complications, regardless of vaccination status against influenza and regardless of the severity of the disease. Seasonal influenza viruses A(H3N2) and A(H1N1)pdm09 currently circulating on the territory of the Russian Federation, are characterized by high sensitivity to neuraminidase inhibitors — oseltamivir and zanamivir, which allows us to recommend these drugs as first-line drugs for the etiotropic therapy of flu.

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The authors declare that there are no conflicts of interest present.