medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-10-32-35medsovet-1864Research ArticleГОЛОВНАЯ БОЛЬ И ГОЛОВОКРУЖЕНИЕHEADACHE AND VERTIGOЦЕРЕБРОВАСКУЛЯРНЫЕ РАССТРОЙСТВА, АССОЦИИРОВАННЫЕ С МИГРЕНЬЮMIGRAINE-ASSOCIATED CEREBROVASCULAR DISORDERSТабееваГ. Р.TabeevaG. R.

Доктор медиинских наук,  профессор

MD, Prof.

Первый Московский государственный медицинский университет им. И.М. СеченоваРоссияSechenov First Moscow State Medical UniversityRussian Federation2017240520170103235Copyright © Табеева Г.Р., 20172017Табеева Г.Р.Tabeeva G.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/1864

Мигрень и цереброваскулярные заболевания являются коморбидными  расстройствами, которые широко распространены в популяции. Тесные взаимоотношения между этими состояниями продемонстрированы  данными эпидемиологических, клинических исследований, а также экспериментальными исследованиями  их патофизиологии. У пациентов  с мигренью наблюдается отчетливое повышение риска ишемического  инсульта, особенно при наличии факторов риска, таких как женский пол, присутствие симптомов ауры, курение, использование гормональных контрацептивов и высокая частота приступов мигрени. Несмотря на обилие исследований, посвященных профилактике мигрени, до сих разработанных стратегий модификации ее лечения у пациентов с сопутствующей патологией не разработано. Между тем некоторые исследования достаточно убедительно демонстрируют преимущества некоторых терапевтических подходов, применение которых могло бы оптимизировать ведение пациентов с этими часто сосуществующими расстройствами.

Migraines and cerebrovascular diseases are comorbid disorders that are widespread in the population. The close relationship between these states is demonstrated by epidemiological, clinical studies, as well as by pilot studies of their pathophysiology. Patients with migraines have a clear increase in the risk of ischemic stroke, especially when there are risk factors such as female sex, presence of aura symptoms, smoking, hormonal contraceptive use and high incidence of migraines. Despite the abundance of migraine studies, no strategies have been developed to modify her treatment for patients with attendant pathology so far. In the meantime, some studies have convincingly demonstrated the advantages of some therapeutic approaches, which could be used to optimize management of these patients with these frequently co-existing disorders.

мигреньмигренозный инфарктишемический инсультинсульт молодого возрастапрофилактика инсультапрофилактическое лечение мигрениmigrainemigraineous infarctionischemic strokestroke of a young ageprevention of strokepreventive treatment of migraineReferencesHarriott AM, Barrett KM. Dissecting the association between migraine and stroke. Curr Neurol Neurosci Rep, 2015, 15: 5.Harriott AM, Barrett KM. Dissecting the association between migraine and stroke. Curr Neurol Neurosci Rep, 2015, 15: 5.Mawet J, Kurth T, Ayata C. Migraine and stroke: in search of shared mechanisms. Cephalalgia, 2015, 35: 165-81.Mawet J, Kurth T, Ayata C. Migraine and stroke: in search of shared mechanisms. Cephalalgia, 2015, 35: 165-81.Gryglas A., Smigiel R. Migraine and Stroke: What’s the Link? What to Do? Curr Neurol Neurosci Rep, 2017, 17: 22.Gryglas A., Smigiel R. Migraine and Stroke: What’s the Link? What to Do? Curr Neurol Neurosci Rep, 2017, 17: 22.Stovner LJ, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A, et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia. 2007, 27(3): 193-210.Stovner LJ, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A, et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia. 2007, 27(3): 193-210.Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, et al. Global and regional burden of stroke during 1990- 2010: findings from the Global Burden of Disease Study 2010. Lancet, 2014, 383: 245-54.Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, et al. Global and regional burden of stroke during 1990- 2010: findings from the Global Burden of Disease Study 2010. Lancet, 2014, 383: 245-54.Collaborative Group for the Study of Stroke in Young Women. Oral contraceptives and stroke in young women. JAMA, 1975, 231(7): 718-22.Collaborative Group for the Study of Stroke in Young Women. Oral contraceptives and stroke in young women. JAMA, 1975, 231(7): 718-22.Kruit MC, van Buchem MA, Hofman PA, Bakkers JTN, Terwindt GM, Ferrari MD, et al. Migraine as a risk factor for subclinical brain lesions. JAMA, 2004, 291(4): 427-34.Kruit MC, van Buchem MA, Hofman PA, Bakkers JTN, Terwindt GM, Ferrari MD, et al. Migraine as a risk factor for subclinical brain lesions. JAMA, 2004, 291(4): 427-34.Kruit MC, van Buchem MA, Launer LJ, Terwindt GM, Ferrari MD. Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: the population-based MRI camera study. Cephalalgia, 2010, 30(2): 129-36.Kruit MC, van Buchem MA, Launer LJ, Terwindt GM, Ferrari MD. Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: the population-based MRI camera study. Cephalalgia, 2010, 30(2): 129-36.Etminan M, Takkouche B, Isorna FC, Samii A. Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies. BMJ, 2005, 330: 63-5.Etminan M, Takkouche B, Isorna FC, Samii A. Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies. BMJ, 2005, 330: 63-5.Schurks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ, 2009, 339: b3914.Schurks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ, 2009, 339: b3914.Spector JT, Kahn SR, Jones MR, Jayakumar M, Dalal D, Nazarian S. Migraine headache and ischemic stroke risk: an updated meta-analysis. Am J Med, 2010, 123: 612-24.Spector JT, Kahn SR, Jones MR, Jayakumar M, Dalal D, Nazarian S. Migraine headache and ischemic stroke risk: an updated meta-analysis. Am J Med, 2010, 123: 612-24.Kurth T, Schürks M, Logroscino G, Buring JE. Migraine frequency and risk of cardiovascular disease in women. Neurology, 2009, 73: 581-8.Kurth T, Schürks M, Logroscino G, Buring JE. Migraine frequency and risk of cardiovascular disease in women. Neurology, 2009, 73: 581-8.Olesen J. Headache classification committee of the international headache society (IHS). The international classification of headache disorders, 3rd edition (beta version). Cephalalgia, 2013, 33: 629-808.Olesen J. Headache classification committee of the international headache society (IHS). The international classification of headache disorders, 3rd edition (beta version). Cephalalgia, 2013, 33: 629-808.Porter A, Gladstone JP, Dodick DW. Migraine and white matter hyperintensities. Curr Pain Headache Rep, 2005, 9: 289-93.Porter A, Gladstone JP, Dodick DW. Migraine and white matter hyperintensities. Curr Pain Headache Rep, 2005, 9: 289-93.Bashir A, Lipton RB, Ashina S, Ashina M. Migraine and structural changes in the brain: a systematic review and meta-analysis. Neurology, 2013, 81: 1260-8.Bashir A, Lipton RB, Ashina S, Ashina M. Migraine and structural changes in the brain: a systematic review and meta-analysis. Neurology, 2013, 81: 1260-8.Rist PM, Dufouil C, Glymour MM, Tzourio C, Kurth T. Migraine and cognitive decline in the populationbased EVA study. Cephalalgia, 2011, 31: 1291-300.Rist PM, Dufouil C, Glymour MM, Tzourio C, Kurth T. Migraine and cognitive decline in the populationbased EVA study. Cephalalgia, 2011, 31: 1291-300.Woods RP, Iacoboni M, Mazziotta JC. Brief report: bilateral spreading cerebral hypoperfusion during spontaneous migraine headache. N Engl J Med, 1994, 331: 1689-1692.Woods RP, Iacoboni M, Mazziotta JC. Brief report: bilateral spreading cerebral hypoperfusion during spontaneous migraine headache. N Engl J Med, 1994, 331: 1689-1692.Tietjen GE, Herial NA, White L, Utley C, Kosmyna JM, Khuder SA. Migraine and biomarkers of endothelial activation in young women. Stroke, 2009, 40: 2977-2982.Tietjen GE, Herial NA, White L, Utley C, Kosmyna JM, Khuder SA. Migraine and biomarkers of endothelial activation in young women. Stroke, 2009, 40: 2977-2982.Sarchielli P, Alberti A, Coppola F, Baldi A, Gallai B, Floridi A, et al. Platelet-activating factor (PAF) in internal jugular venous blood of migraine without aura patients assessed during migraine attacks. Cephalalgia, 2004, 24: 623-630.Sarchielli P, Alberti A, Coppola F, Baldi A, Gallai B, Floridi A, et al. Platelet-activating factor (PAF) in internal jugular venous blood of migraine without aura patients assessed during migraine attacks. Cephalalgia, 2004, 24: 623-630.Табеева Г.Р. Мигрень и цереброваскулярная патология. Справочник поликлинического врача. 2014, 3: 45.Табеева Г.Р. Мигрень и цереброваскулярная патология. Справочник поликлинического врача. 2014, 3: 45.Сhabriat H, Joutel A, Dichgans M, TournierLasserve E, Bousser MG. Cadasil. Lancet Neurol, 2009, 8: 643-653.Сhabriat H, Joutel A, Dichgans M, TournierLasserve E, Bousser MG. Cadasil. Lancet Neurol, 2009, 8: 643-653.Tietjen GE, Herial NA, White L, Utley C, Kosmyna JM, Khuder SA. Migraine and biomarkers of endothelial activation in young women. Stroke, 2009, 40: 2977-2982.Tietjen GE, Herial NA, White L, Utley C, Kosmyna JM, Khuder SA. Migraine and biomarkers of endothelial activation in young women. Stroke, 2009, 40: 2977-2982.Азимова Ю.Э., Табеева Г.Р., Климов Е.А. Генетика мигрени (научный обзор). Анналы неврологии, 2008, 2(1): 41-45.Азимова Ю.Э., Табеева Г.Р., Климов Е.А. Генетика мигрени (научный обзор). Анналы неврологии, 2008, 2(1): 41-45.Сhabriat H, Joutel A, Dichgans M, TournierLasserve E, Bousser MG. Cadasil. Lancet Neurol, 2009, 8: 643-653.Сhabriat H, Joutel A, Dichgans M, TournierLasserve E, Bousser MG. Cadasil. Lancet Neurol, 2009, 8: 643-653.Silberstein SD, Holland S, Freitag F, Dodick DW, Argoff C, Ashman E. Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology, 2012, 78: 1337-1345.Silberstein SD, Holland S, Freitag F, Dodick DW, Argoff C, Ashman E. Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology, 2012, 78: 1337-1345.Tronvik E, Stovner LJ, Helde G, Sand T, Bovim G. Prophylactic treatment of migraine with an angiotensin II receptor blocker: a randomized controlled trial. JAMA, 2003, 289: 65-69.Tronvik E, Stovner LJ, Helde G, Sand T, Bovim G. Prophylactic treatment of migraine with an angiotensin II receptor blocker: a randomized controlled trial. JAMA, 2003, 289: 65-69.Schrader H, Stovner LJ, Helde G, Sand T, Bovim G. Prophylactic treatment of migraine with angiotensin converting enzyme inhibitor (lisinopril): randomised, placebo controlled, crossover study. BMJ, 2001, 322: 19-22.Schrader H, Stovner LJ, Helde G, Sand T, Bovim G. Prophylactic treatment of migraine with angiotensin converting enzyme inhibitor (lisinopril): randomised, placebo controlled, crossover study. BMJ, 2001, 322: 19-22.Bucelli RC, Gonsiorek EA, Kim WY, Bruun D, Rabin RA, Higgins D, et al. Statins decrease expression of the proinflammatory neuropeptides calcitonin generelated peptide and substance P in sensory neurons. J Pharmacol Exp Ther, 2008, 324: 1172-1180.Bucelli RC, Gonsiorek EA, Kim WY, Bruun D, Rabin RA, Higgins D, et al. Statins decrease expression of the proinflammatory neuropeptides calcitonin generelated peptide and substance P in sensory neurons. J Pharmacol Exp Ther, 2008, 324: 1172-1180.

The authors declare that there are no conflicts of interest present.