medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-10-69-72medsovet-1870Research ArticleЗаболевания периферической нервной системыPERIPHERAL NERVOUS SYSTEM DISEASESДИАГНОСТИКА И ПОДХОДЫ К ВЕДЕНИЮ ПАЦИЕНТОВ С НЕВРОПАТИЧЕСКОЙ БОЛЬЮDIAGNOSES AND APPROACHES TO PATIENTS WITH NEUROTIC PAINСтарчинаЮ. А.StarchinaY. A.

Кандидат медицинских наук

PhD  in medicine

Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава РоссииРоссияSechenov First Moscow State University of the Ministry of Health of RussiaRussian Federation2017250520170106972Copyright © Старчина Ю.А., 20172017Старчина Ю.А.Starchina Y.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/1870

В статье представлены общие вопросы эпидемиологии, диагностики, клинической характеристики невропатической боли. Обсуждается возможность применения у пациентов с болевыми формами невропатий биологически активной добавки Келтикан комплекс, содержащей нуклеотид уридинмонофосфат, витамин В12 и фолиевую кислоту.

The article presents general issues of epidemiology, diagnosis, clinical performance of neurotic pain. The possibility of use in patient with painful forms of neuropathiesa of dbiologically active additive Keltikan Complex containing nucleotide uridine monophosphate, vitamin B12 and folic acid to patients with is discussed.

невропатическая больболевые невропатииКелтикан комплексмононуклеотидыуридинмонофосфатвитамин В12фолиевая кислотаneuropathic painpain neuropathiesKeltikan Complexmononucleotidesuridine monophosphatevitamin B12folic acidReferencesBreivik H, Collett B, Ventafridda V et al. Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment. Eur J Pain, 2006, 10: 287-333.Breivik H, Collett B, Ventafridda V et al. Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment. Eur J Pain, 2006, 10: 287-333.Яхно Н.Н., Кукушкин М.Л., Давыдов О.С. и др. Результаты Российского эпидемиологического исследования распространенности невропатической боли, ее причин и характеристик в популяции амбулаторных больных, обратившихся к врачу-неврологу. Боль, 2008, 3: 24-32.Яхно Н.Н., Кукушкин М.Л., Давыдов О.С. и др. Результаты Российского эпидемиологического исследования распространенности невропатической боли, ее причин и характеристик в популяции амбулаторных больных, обратившихся к врачу-неврологу. Боль, 2008, 3: 24-32.Kashikar-Zuck S, Cunningham N, Sil S, et al. Long-term outcomes of adolescents with juvenile-onset fibromyalgia in early adulthood. Pediatrics, 2014 Mar, 133(3): e592-600.Kashikar-Zuck S, Cunningham N, Sil S, et al. Long-term outcomes of adolescents with juvenile-onset fibromyalgia in early adulthood. Pediatrics, 2014 Mar, 133(3): e592-600.Kroenke K, Bair MJ, Damush TM, et al. Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: a randomized controlled trial. JAMA, 2009 May 27, 301(20): 2099-110.Kroenke K, Bair MJ, Damush TM, et al. Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: a randomized controlled trial. JAMA, 2009 May 27, 301(20): 2099-110.Jensen TS, Baron R, Haanpää M, Kalso E, Loeser JD, Rice AS, et al. A new definition of neuropathic pain. Pain, 2011, 152: 2204-5.Jensen TS, Baron R, Haanpää M, Kalso E, Loeser JD, Rice AS, et al. A new definition of neuropathic pain. Pain, 2011, 152: 2204-5.Bouhassira D, Lante’ri-Minet M, Attal N, Laurent B, Touboul C. Prevalence of chronic pain with neuropathic characteristics in the general population. Pain, 2008, 136: 380-7.Bouhassira D, Lante’ri-Minet M, Attal N, Laurent B, Touboul C. Prevalence of chronic pain with neuropathic characteristics in the general population. Pain, 2008, 136: 380-7.Gilron I, Baron R, Jensen T. Neuropathic pain: principles of diagnosis and treatment. Mayo Clin Proc, 2015, 90(4): 532-45.Gilron I, Baron R, Jensen T. Neuropathic pain: principles of diagnosis and treatment. Mayo Clin Proc, 2015, 90(4): 532-45.Di Bonaventura M, Sadosky A, Concialdi K, Hopps M et al. The prevalence of broad neuropathic pain in the United States: results from a multi-channel general population health survey. J Pain, 2016 Apr, 17(4S): S11.Di Bonaventura M, Sadosky A, Concialdi K, Hopps M et al. The prevalence of broad neuropathic pain in the United States: results from a multi-channel general population health survey. J Pain, 2016 Apr, 17(4S): S11.Treede RD, Jensen TS, Campbell JN, et al. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology, 2008 Apr 29, 70(18): 1630-5. Epub 2007 Nov 14.5.Treede RD, Jensen TS, Campbell JN, et al. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology, 2008 Apr 29, 70(18): 1630-5. Epub 2007 Nov 14.5.Cruccua G, Sommera C, Anand P, et al. EFNS guidelines on neuropathic pain assessment: revised 2009. Eur J Neurol, 2010.Cruccua G, Sommera C, Anand P, et al. EFNS guidelines on neuropathic pain assessment: revised 2009. Eur J Neurol, 2010.Анисимова Е.И., Данилов А.Б. Невропатический болевой синдром: клинико-нейрофизиологический анализ. Журнал неврологии и психиатрии им. С.С. Корсакова, 2003, 10: 19-20.Анисимова Е.И., Данилов А.Б. Невропатический болевой синдром: клинико-нейрофизиологический анализ. Журнал неврологии и психиатрии им. С.С. Корсакова, 2003, 10: 19-20.Баринов А.Н. Современные достижения в понимании механизмов формирования и лечения хронической боли. Неврологический журнал, 2003, 56: 57-61.Баринов А.Н. Современные достижения в понимании механизмов формирования и лечения хронической боли. Неврологический журнал, 2003, 56: 57-61.Строков И.А., Баринов А.Н. Клиника, патогенез и лечение болевого синдрома при диабетической полиневропатии. Неврологический журнал, 2001, 6: 47-55.Строков И.А., Баринов А.Н. Клиника, патогенез и лечение болевого синдрома при диабетической полиневропатии. Неврологический журнал, 2001, 6: 47-55.Кукушкин М.Л., Хитров Н.К. Общая патология боли. М.: Медицина, 2004, 144 с.Кукушкин М.Л., Хитров Н.К. Общая патология боли. М.: Медицина, 2004, 144 с.Martyn CN, Hughes RA. Epidemiology of peripheral neuropathy. J. Neurol. Neurosurg. Psychiatr., 1997, 62(4): 310-318.Martyn CN, Hughes RA. Epidemiology of peripheral neuropathy. J. Neurol. Neurosurg. Psychiatr., 1997, 62(4): 310-318.Dyck PJ, Kratz KM, Karnes JL et al. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy and neuropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology, 1993, 43(4): 817-824.Dyck PJ, Kratz KM, Karnes JL et al. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy and neuropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology, 1993, 43(4): 817-824.Attala N, Cruccu G, Baron R, Haanpää M, Hansson P, Jensen TS, Nurmikko T. European Federation of Neurological Societies. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol, 2010, 17(9): 1113-e88.Attala N, Cruccu G, Baron R, Haanpää M, Hansson P, Jensen TS, Nurmikko T. European Federation of Neurological Societies. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol, 2010, 17(9): 1113-e88.Bouhassira D, Lanteґri-Minet M, Attal N, Laurent B, Touboul C. Prevalence of chronic pain with neuropathic characteristics in the general population. Pain, 2008, 136(3): 380-387.Bouhassira D, Lanteґri-Minet M, Attal N, Laurent B, Touboul C. Prevalence of chronic pain with neuropathic characteristics in the general population. Pain, 2008, 136(3): 380-387.Torrance N, Ferguson JA, Afolabi E, Bennett MI et al. Neuropathic pain in the community: more under-treated than refractory? Pain, 2013, 154(5): 690-698.Torrance N, Ferguson JA, Afolabi E, Bennett MI et al. Neuropathic pain in the community: more under-treated than refractory? Pain, 2013, 154(5): 690-698.Baron R, Binder A, Wasner G. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol, 2010, 9(8): 807-819.Baron R, Binder A, Wasner G. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol, 2010, 9(8): 807-819.Корешкина М.И. Невропатическая боль. Проблемы и решения. Нервные болезни, 2016, 4: 34-37.Корешкина М.И. Невропатическая боль. Проблемы и решения. Нервные болезни, 2016, 4: 34-37.Wattig B, Schalow G, Heydenreich F, Warzok R, Cervós-Navarro J. Enhancement of nerve fibre regeneration by nucleotides after peripheral nerve crush damage. Electrophysiologic and morphometric investigations. Arzneimittelforschung, 1992, 42: 1075-1078.Wattig B, Schalow G, Heydenreich F, Warzok R, Cervós-Navarro J. Enhancement of nerve fibre regeneration by nucleotides after peripheral nerve crush damage. Electrophysiologic and morphometric investigations. Arzneimittelforschung, 1992, 42: 1075-1078.Wattig B, Schalow G, Madauss M, Heydenreich F, Warzok R, Cervós-Navarro J. Acceleration of nerve and muscle regeneration by administration of nucleotides – electroneurophysiological and morphometrical investigations. Acta Histochem, 1992, Suppl. 42: 333-339.Wattig B, Schalow G, Madauss M, Heydenreich F, Warzok R, Cervós-Navarro J. Acceleration of nerve and muscle regeneration by administration of nucleotides – electroneurophysiological and morphometrical investigations. Acta Histochem, 1992, Suppl. 42: 333-339.Okada M, Nakagawa T, Minami M, Satoh M. Analgesic effects of intrathecal administration of P2Y nucleotide receptor agonists UTP and UDP in normal and neuropathic pain model in rats. J. Pharmacol. Exp. Ther., 2002, 303(1): 66-73.Okada M, Nakagawa T, Minami M, Satoh M. Analgesic effects of intrathecal administration of P2Y nucleotide receptor agonists UTP and UDP in normal and neuropathic pain model in rats. J. Pharmacol. Exp. Ther., 2002, 303(1): 66-73.Negrão L, Almeida P, Alcino S, Duro H. et al. Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Manag, 2014, 4(3): 191-196.Negrão L, Almeida P, Alcino S, Duro H. et al. Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Manag, 2014, 4(3): 191-196.Negrão L, Nunes P. Uridine monophosphate, folic acid and vitamin B12 in patients with symptomatic peripheral entrapment neuropathies. Pain Manag, 2016, 6(1): 25-9. doi: 10.2217/pmt.15.60. Epub 2015 Dec 17.Negrão L, Nunes P. Uridine monophosphate, folic acid and vitamin B12 in patients with symptomatic peripheral entrapment neuropathies. Pain Manag, 2016, 6(1): 25-9. doi: 10.2217/pmt.15.60. Epub 2015 Dec 17.

The authors declare that there are no conflicts of interest present.