References

medsovet

Медицинский Совет

Meditsinskiy sovet = Medical Council

2079-701X2658-5790

REMEDIUM GROUP Ltd.

10.21518/2079-701X-2017-10-102-109

medsovet-1876

Research Article

Практика

Practice

ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ ФИКСИРОВАННОЙ КОМБИНАЦИИ ПИРАЦЕТАМА И ЦИННАРИЗИНА В НЕВРОЛОГИЧЕСКОЙ ПРАКТИКЕ

POSSIBILITIES TO USE A FIXED COMBINATION OF PIRACETAM AND CINNARIZINE IN NEUROLOGICAL PRACTICE

Титова

Н. В.

Titova

N. V.

Кандидат медицинских наук.

Москва

PhD in medicine.

Moscow

Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава РоссииРоссияPirogov Russian National Research Medical University of the Ministry of Health of RussiaRussian Federation

2017

25052017

010102109

2017

Титова Н.В.

Titova N.V.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.med-sovet.pro/jour/article/view/1876

Статья посвящена обсуждению возможностей применения комплексного препарата Фезам, содержащего 400 мг пирацетама и 25 мг циннаризина, в неврологической практике. Преимущество комбинации ноотропного и вазоактивного веществ объясняется сбалансированным разносторонним влиянием на разные звенья патогенеза заболеваний. Пирацетам оказывает влияние на текучесть мембран клеток, нейротрансмиссию, обладает нейропротекторным эффектом, влияет на нейропластичность, энергетический обмен в клетке и сосудистые механизмы (эритроциты, сосудистую стенку и коагуляцию). Второй компонент препарата циннаризин имеет вазодилатирующие свойства, подавляет активность лабиринта и улучшает реологические свойства крови. При обсуждении лекарственного паркинсонизма описываются противоположные эффекты компонентов препарата на дофаминергическую систему. Препарат Фезам показал свою эффективность в профилактическом лечении мигрени (снижение частоты и интенсивности приступов). У пациентов с хронической ишемией головного мозга Фезам улучшал неврологический статус, когнитивные функции, показатели кровотока и качество жизни. Приводятся данные о положительных эффектах Фезама в восстановительном периоде ишемического инсульта с речевыми и умеренными когнитивными расстройствами. Особенностями режима дозирования является возможность использования как низко-, так и высокодозной терапии. Препарат показал хорошую переносимость и экономические преимущества по сравнению с применением активных веществ по отдельности.

The article discusses the possibility of using the complex drug Phezam, containing 400 mg of Piracetam and 25 mg of Cinnarizine in neurological practice. The advantage of a combination of nootropic and vasoactive substances is due to a balanced and diversified influence on the different links of pathogenesis diseases. Piracetam targets the turnover of cell membranes, neurotransmission, has a neuroprotective effect, influences the neuroplasticity, the energy exchange in the cage and the vascular mechanisms (blood cells, cardiovascular wall and coagulation). The second component of the drug Cinnarizine has vasodilatating properties, suppresses the activity of the labyrinth and improves flow blood properties. When discussing the drug-induced parkinsonism, the opposite effects of the drug components on the dopaminergic system are described. The Phezam has shown its efficacy in the preventive treatment of migraines (reducing of frequency and intensity of seizures). In patients with chronic brain ischemia Phezam improved a neurological status, cognitive functions, blood flow indicators, and quality of life. The positive effects of Phezam during the recovery period of ischaemic stroke with speech and moderate cognitive disorders are reported. The characteristics of the metering regime are the possibility to use low-and high-dosage therapy. The drug showed good tolerability and economic advantages over the use of active substances separately.

пирацетамциннаризинноотропная терапиялекарственный паркинсонизммигреньхроническая ишемия головного мозгаастенический синдромФезам

PiracetamCinnarizinenootropic therapydrug-induced parkinsonismmigrainechronic brain ischemiaasthenic syndromePhezam

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The authors declare that there are no conflicts of interest present.