<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2017-10-132-135</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-1880</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДИССЕРТАНТ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DISSERTANT</subject></subj-group></article-categories><title-group><article-title>СиПАП-ТЕРАПИЯ СНИЖАЕТ УРОВЕНЬ ГЛИКИРОВАННОГО ГЕМОГЛОБИНА У БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ ВТОРОГО ТИПА И СИНДРОМОМ АПНОЭ СНА</article-title><trans-title-group xml:lang="en"><trans-title>CPAP-THERAPY DECREASES GLYCATED HEMOGLOBIN IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND SLEEP APNOEA</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурчаков</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Burchakov</surname><given-names>D. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Майоров</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Mayorov</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медиинских наук, профессор</p></bio><bio xml:lang="en"><p>MD, Prof.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова; Эндокринологический научный центр</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University; Endocrinological Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>25</day><month>05</month><year>2017</year></pub-date><volume>0</volume><issue>10</issue><fpage>132</fpage><lpage>135</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бурчаков Д.И., Майоров А.Ю., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Бурчаков Д.И., Майоров А.Ю.</copyright-holder><copyright-holder xml:lang="en">Burchakov D.I., Mayorov A.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/1880">https://www.med-sovet.pro/jour/article/view/1880</self-uri><abstract><p>Среди больных сахарным диабетом второго типа (СД 2-го типа) широко распространен синдром обструктивного апноэ сна (СОАС), который негативно влияет на состояние углеводного обмена и качество сна. Стандартом лечения СОАС является СиПАП-терапия. В данном ретроспективном когортном исследовании оценили влияние СиПАП-терапии на уровень гликированного гемоглобина  (HbA1c) у 34  больных СД 2-го типа, получающих сахароснижающую  терапию. В результате 3 месяцев лечения отмечено снижение HbA1c на 0,7%, исчезновение дневной сонливости, а также в подавляющем большинстве случаев нормализация  качества сна. Таким образом, при сочетании  СД 2-го типа и СОАС средней или тяжелой степени  СиПАП-терапия оказывает самостоятельное благотворное влияние на состояние углеводного обмена.</p></abstract><trans-abstract xml:lang="en"><p>Among the Type 2 Diabetes Mellitus (Type 2 DB) patients obstructive sleep apnoea (OSA) syndrome, which adversely affects the state of carbohydrate exchange and the quality of sleep, is widespread. The standard for the treatment of OSA is CPAP therapy. In this retrospective cohort study, the influence of CPAP-therapy on the level of glycosylated haemoglobin (HbA1c) was assessed in the 34 second-type SR patients receiving sugar-reducing therapy. As a result of 3 months of treatment, there has been a decrease of HbA1c by 0.7%, the disappearance of day sleepiness, and the overwhelming majority of normalization of the quality of sleep. Thus, with the combination of the Type 2 DM and the OSA of medium or heavy degree, CPAP therapy  has an independent beneficial effect on the state of carbohydrate exchange.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром апноэ сна</kwd><kwd>СиПАП-терапия</kwd><kwd>гликированный гемоглобин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Sleep apnea syndrome</kwd><kwd>CPAP therapy</kwd><kwd>glycosylated hemoglobin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Мисникова И.В. Апноэ сна при эндокринной патологии. Альманах Клинической Медицины, 2016, 44: 493–500. doi: 10.18786/2072-0505-2016-44-4-493-500.</mixed-citation><mixed-citation xml:lang="en">Мисникова И.В. Апноэ сна при эндокринной патологии. Альманах Клинической Медицины, 2016, 44: 493–500. doi: 10.18786/2072-0505-2016-44-4-493-500.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Torrella M, Castells I, Gimenez-Perez G, Recasens A, Miquel M, Simó O, et al. Intermittent hypoxia is an independent marker of poorer glycaemic control in patients with uncontrolled type 2 diabetes. Diabetes Metab, 2015, 41: 312–8. doi: 10.1016/j.diabet.2015.01.002.</mixed-citation><mixed-citation xml:lang="en">Torrella M, Castells I, Gimenez-Perez G, Recasens A, Miquel M, Simó O, et al. Intermittent hypoxia is an independent marker of poorer glycaemic control in patients with uncontrolled type 2 diabetes. Diabetes Metab, 2015, 41: 312–8. doi: 10.1016/j.diabet.2015.01.002.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Aronsohn RS, Whitmore H, Van Cauter E, Tasali E. Impact of Untreated Obstructive Sleep Apnea on Glucose Control in Type 2 Diabetes. Am J Respir Crit Care Med, 2010, 181: 507-13. doi: 10.1164/rccm.200909-1423OC.</mixed-citation><mixed-citation xml:lang="en">Aronsohn RS, Whitmore H, Van Cauter E, Tasali E. Impact of Untreated Obstructive Sleep Apnea on Glucose Control in Type 2 Diabetes. Am J Respir Crit Care Med, 2010, 181: 507-13. doi: 10.1164/rccm.200909-1423OC.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kushida CA, Chediak A, Berry RB, Brown LK, Gozal D, Iber C, et al. Clinical guidelines for the manual titration of positive airway pressure in patients with obstructive sleep apnea. J Clin Sleep Med, 2008, 4: 157-71.</mixed-citation><mixed-citation xml:lang="en">Kushida CA, Chediak A, Berry RB, Brown LK, Gozal D, Iber C, et al. Clinical guidelines for the manual titration of positive airway pressure in patients with obstructive sleep apnea. J Clin Sleep Med, 2008, 4: 157-71.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Martínez-Cerón E, Barquiel B, Bezos A-M, Casitas R, Galera R, García-Benito C, et al. Effect of Continuous Positive Airway Pressure on Glycemic Control in Patients with Obstructive Sleep Apnea and Type 2 Diabetes. A Randomized Clinical Trial. Am J Respir Crit Care Med, 2016, 194: 476–85. doi: 10.1164/rccm.201510-1942OC.</mixed-citation><mixed-citation xml:lang="en">Martínez-Cerón E, Barquiel B, Bezos A-M, Casitas R, Galera R, García-Benito C, et al. Effect of Continuous Positive Airway Pressure on Glycemic Control in Patients with Obstructive Sleep Apnea and Type 2 Diabetes. A Randomized Clinical Trial. Am J Respir Crit Care Med, 2016, 194: 476–85. doi: 10.1164/rccm.201510-1942OC.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res, 1989, 28: 193–213.</mixed-citation><mixed-citation xml:lang="en">Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res, 1989, 28: 193–213.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep, 1991, 14: 540–5.</mixed-citation><mixed-citation xml:lang="en">Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep, 1991, 14: 540–5.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Fredheim JM, Røislien J, Hjelmesæth J. Validation of a portable monitor for the diagnosis of obstructive sleep apnea in morbidly obese patients. J Clin Sleep Med, 2014, 10: 751–7, 757A. doi: 10.5664/jcsm.3864.</mixed-citation><mixed-citation xml:lang="en">Fredheim JM, Røislien J, Hjelmesæth J. Validation of a portable monitor for the diagnosis of obstructive sleep apnea in morbidly obese patients. J Clin Sleep Med, 2014, 10: 751–7, 757A. doi: 10.5664/jcsm.3864.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ng SSS, Chan T-O, To K-W, Ngai J, Tung A, Ko FWS, et al. Validation of a portable recording device (ApneaLink) for identifying patients with suspected obstructive sleep apnoea syndrome. Intern Med J, 2009, 39: 757–62. doi: 10.1111/j.1445-5994.2008.01827.x.</mixed-citation><mixed-citation xml:lang="en">Ng SSS, Chan T-O, To K-W, Ngai J, Tung A, Ko FWS, et al. Validation of a portable recording device (ApneaLink) for identifying patients with suspected obstructive sleep apnoea syndrome. Intern Med J, 2009, 39: 757–62. doi: 10.1111/j.1445-5994.2008.01827.x.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Morgenthaler TI, Aurora RN, Brown T, Zak R, Alessi C, Boehlecke B, et al. Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: an update for 2007. An American Academy of Sleep Medicine report. Sleep, 2008, 31: 141–7.</mixed-citation><mixed-citation xml:lang="en">Morgenthaler TI, Aurora RN, Brown T, Zak R, Alessi C, Boehlecke B, et al. Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: an update for 2007. An American Academy of Sleep Medicine report. Sleep, 2008, 31: 141–7.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Schwab RJ, Badr SM, Epstein LJ, Gay PC, Gozal D, Kohler M, et al. An Official American Thoracic Society Statement: Continuous Positive Airway Pressure Adherence Tracking Systems. The Optimal Monitoring Strategies and Outcome Measures in Adults. Am J Respir Crit Care Med, 2013, 188: 613–20. doi: 10.1164/rccm.201307-1282ST.</mixed-citation><mixed-citation xml:lang="en">Schwab RJ, Badr SM, Epstein LJ, Gay PC, Gozal D, Kohler M, et al. An Official American Thoracic Society Statement: Continuous Positive Airway Pressure Adherence Tracking Systems. The Optimal Monitoring Strategies and Outcome Measures in Adults. Am J Respir Crit Care Med, 2013, 188: 613–20. doi: 10.1164/rccm.201307-1282ST.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Шестакова М.В. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. 7-й выпуск. Diabetes Mellit, 2015, 18: 1–112. doi: 10.14341/DM20131S1-121.</mixed-citation><mixed-citation xml:lang="en">Дедов И.И., Шестакова М.В. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. 7-й выпуск. Diabetes Mellit, 2015, 18: 1–112. doi: 10.14341/DM20131S1-121.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hassaballa H, Tulaimat A, Herdegen JJ, Mokhlesi B. The effect of continuous positive airway pressure on glucose control in diabetic patients with severe obstructive sleep apnea. Sleep Breath, 2005, 9: 176–80. doi: 10.1007/s11325-005-0033-y.</mixed-citation><mixed-citation xml:lang="en">Hassaballa H, Tulaimat A, Herdegen JJ, Mokhlesi B. The effect of continuous positive airway pressure on glucose control in diabetic patients with severe obstructive sleep apnea. Sleep Breath, 2005, 9: 176–80. doi: 10.1007/s11325-005-0033-y.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Harsch IA, Schahin SP, Brückner K, RadespielTröger M, Fuchs FS, Hahn EG, et al. The Effect of Continuous Positive Airway Pressure Treatment on Insulin Sensitivity in Patients with Obstructive Sleep Apnoea Syndrome and Type 2 Diabetes. Respiration, 2004, 71: 252–9. doi: 10.1159/000077423.</mixed-citation><mixed-citation xml:lang="en">Harsch IA, Schahin SP, Brückner K, RadespielTröger M, Fuchs FS, Hahn EG, et al. The Effect of Continuous Positive Airway Pressure Treatment on Insulin Sensitivity in Patients with Obstructive Sleep Apnoea Syndrome and Type 2 Diabetes. Respiration, 2004, 71: 252–9. doi: 10.1159/000077423.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Smurra M, Philip P, Taillard J, Guilleminault C, Bioulac B, Gin H. CPAP treatment does not affect glucose-insulin metabolism in sleep apneic patients. Sleep Med, 2001, 2: 207–13.</mixed-citation><mixed-citation xml:lang="en">Smurra M, Philip P, Taillard J, Guilleminault C, Bioulac B, Gin H. CPAP treatment does not affect glucose-insulin metabolism in sleep apneic patients. Sleep Med, 2001, 2: 207–13.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Grimaldi D, Beccuti G, Touma C, Van Cauter E, Mokhlesi B. Association of Obstructive Sleep Apnea in Rapid Eye Movement Sleep With Reduced Glycemic Control in Type 2 Diabetes: Therapeutic Implications. Diabetes Care, 2014, 37.</mixed-citation><mixed-citation xml:lang="en">Grimaldi D, Beccuti G, Touma C, Van Cauter E, Mokhlesi B. Association of Obstructive Sleep Apnea in Rapid Eye Movement Sleep With Reduced Glycemic Control in Type 2 Diabetes: Therapeutic Implications. Diabetes Care, 2014, 37.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Teramoto S, Yamaguchi Y, Yamamoto H, Hanaoka Y, Ishii M, Hibi S, et al. Cardiovascular and metabolic effects of CPAP in obese obstructive sleep apnoea patients. Eur Respir J Off J Eur Soc Clin Respir Physiol, 2008, 31: 222–3. doi: 10.1183/09031936.00085707.</mixed-citation><mixed-citation xml:lang="en">Teramoto S, Yamaguchi Y, Yamamoto H, Hanaoka Y, Ishii M, Hibi S, et al. Cardiovascular and metabolic effects of CPAP in obese obstructive sleep apnoea patients. Eur Respir J Off J Eur Soc Clin Respir Physiol, 2008, 31: 222–3. doi: 10.1183/09031936.00085707.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao YY, Wang R, Gleason KJ, Lewis EF, Quan SF, Toth CM, et al. Effect of continuous positive airway pressure treatment on health-related quality of life and sleepiness in high cardiovascular risk individuals with sleep apnea: Best Apnea Interventions for Research (BestAIR) Trial. Sleep, 2017. doi: 10.1093/sleep/zsx040.</mixed-citation><mixed-citation xml:lang="en">Zhao YY, Wang R, Gleason KJ, Lewis EF, Quan SF, Toth CM, et al. Effect of continuous positive airway pressure treatment on health-related quality of life and sleepiness in high cardiovascular risk individuals with sleep apnea: Best Apnea Interventions for Research (BestAIR) Trial. Sleep, 2017. doi: 10.1093/sleep/zsx040.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
