References

medsovet

Медицинский Совет

Meditsinskiy sovet = Medical Council

2079-701X2658-5790

REMEDIUM GROUP Ltd.

10.21518/2079-701X-2017-6-62-70

medsovet-1888

Research Article

Химиотерапия злокачественных опухолей

Malignant tumor chemotherapy

КОМБИНИРОВАННЫЕ РЕЖИМЫ ХИМИОТЕРАПИИ ПРИ РАКЕ ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ

COMBINATION CHEMOTHERAPY REGIMENS IN PANCREATIC CANCER

ПОПОВА

А. С.

POPOVA

A. S.

ПОКАТАЕВ

И. А.

POKATAEV

I. A.

к.м.н.

PhD in Medicine

ТЮЛЯНДИН

С. А.

TYULYANDIN,

S. A.

д.м.н., профессор

MD, Prof.

Российский онкологический научный центр им. Н.Н. Блохина Минздрава РоссииРоссияN.N. Blokhin Russian Cancer Research Center, MoH RFRussian Federation

2017

17062017

066270

2017

ПОПОВА А.С., ПОКАТАЕВ И.А., ТЮЛЯНДИН С.А.

POPOVA A.S., POKATAEV I.A., TYULYANDIN, S.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.med-sovet.pro/jour/article/view/1888

Рак поджелудочной железы характеризуется агрессивным течением и высоким метастатическим потенциалом, в связи с чем в большинстве случаев заболевание выявляется на неоперабельных стадиях. Основным методом лечения местнораспространенного и метастатического рака поджелудочной железы является химиотерапия. До недавнего времени стандартом химиотерапии данной патологии считалась монотерапия гемцитабином, пока в клиническую практику не вошли более эффективные режимы комбинированной химиотерапии (FOLFIRINOX и комбинация nab-паклитаксела с гемцитабином). Назначение данных схем химиотерапии лимитирует относительно высокая токсичность, что делает невозможным их применение у ослабленных пациентов и у больных с серьезной сопутствующей патологией. В настоящей работе рассматриваются критерии выбора оптимального режима комбинированной химиотерапии на основе оценки состояния пациента, возможности управления побочными эффектами химиотерапии, а также молекулярно-биологические характеристики опухоли.

Pancreatic cancer is characterized by its aggressive behaviour and high metastatic potential, and in most cases the disease is detected in inoperable stages. The main method of treatment of locally advanced and metastatic pancreatic cancer is chemotherapy. Until recently, gemcitabine monotherapy was considered the standard of chemotherapy; until the moment when more effective regimens of combination chemotherapy (FOLFIRINOX and the combination of nab-paclitaxel plus gemcitabine) were included in clinical practice. Application of these chemotherapy regimens is limited by their relatively high toxicity, which makes their use impossible in fragile patients and in patients with serious concomitant pathology. The article highlights criteria for choosing the best regimen of combination chemotherapy based on the assessment of patient’s condition, the possibility to manage side effects of chemotherapy, and the molecular and biological characteristics of the tumor.

рак поджелудочной железыFOLFIRINOXnab-паклитакселэрлотинибтоксичность химиотерапии

pancreatic cancerFOLFIRINOXnab-paclitaxelerlotinibtoxicity of chemotherapy

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The authors declare that there are no conflicts of interest present.