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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2017-6-88-92</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-1891</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Поддерживающая терапия в онкологии</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Supportive care in oncology</subject></subj-group></article-categories><title-group><article-title>ПРОФИЛАКТИКА ТРОМБОТИЧЕСКИХ ОСЛОЖНЕНИЙ У ОНКОЛОГИЧЕСКИХ БОЛЬНЫХ В ГРУППАХ ВЫСОКОГО РИСКА</article-title><trans-title-group xml:lang="en"><trans-title>PREVENTION OF THROMBOTHIC COMPLICATIONS IN CANCER PATIENTS IN HIGH-RISK GROUPS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ПТУШКИН</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>PTUSHKIN</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><bio xml:lang="en"><p>MD, Prof.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГКБ им. С.П. Боткина ДЗ г. Москвы</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>19</day><month>06</month><year>2017</year></pub-date><volume>0</volume><issue>6</issue><fpage>88</fpage><lpage>92</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; ПТУШКИН В.В., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">ПТУШКИН В.В.</copyright-holder><copyright-holder xml:lang="en">PTUSHKIN V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/1891">https://www.med-sovet.pro/jour/article/view/1891</self-uri><abstract><p>Венозные тромбозы/тромбоэмболии (ВТЭ) являются частым осложнением и признаются одной из основных причин смертности у пациентов с опухолями. Обычно у онкологических больных имеется несколько факторов риска развития венозного тромбоза, в том числе операция, иммобилизация, наличие центрального катетера, химиотерапия. Эффективная профилактика и лечение ВТЭ снижают уровень заболеваемости и смертности, а также улучшают качество жизни онкологических больных. Низкомолекулярные гепарины (НМГ) являются эффективными и безопасными средствами для профилактики и лечения ВТЭ при раке.</p></abstract><trans-abstract xml:lang="en"><p>Venous thromboembolism (VTE) is a common complication in patients with malignant disease. Cancer-associated thrombosis is a major cause of morbidity and mortality in patients with cancer. Several risk factors for developing venous thrombosis usually coexist in cancer patients including surgery, hospital admissions and immobilization, the presence of an indwelling central catheter, chemotherapy. Effective prophylaxis and treatment of VTE reduced morbidity and mortality, and improved quality of life. Low-molecular-weight heparin (LMWH) is preferred as an effective and safe means for prophylaxis and treatment of VTE.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>онкология</kwd><kwd>тромбозы</kwd><kwd>профилактика</kwd><kwd>низкомолекулярные гепарины</kwd><kwd>бемипарин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>oncology</kwd><kwd>thrombosis</kwd><kwd>prophylaxis</kwd><kwd>low molecular weight heparins</kwd><kwd>bemiparin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Shen VS, Pollak EW. Fatal pulmonary embolism in cancer patients: is heparin prophylaxis justified? South Med J, 1980, 73: 841-843.</mixed-citation><mixed-citation xml:lang="en">Shen VS, Pollak EW. Fatal pulmonary embolism in cancer patients: is heparin prophylaxis justified? South Med J, 1980, 73: 841-843.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Deitcher SR. Cancer-related deep venous thrombosis: clinical importance, treatment challenges, and management strategies. Semin Thromb Hemost, 2003, 29: 247-583.</mixed-citation><mixed-citation xml:lang="en">Deitcher SR. Cancer-related deep venous thrombosis: clinical importance, treatment challenges, and management strategies. Semin Thromb Hemost, 2003, 29: 247-583.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Peuscher FW. Thrombosis and bleeding in cancer patients. Neth J Med, 1981, 24: 23-35.</mixed-citation><mixed-citation xml:lang="en">Peuscher FW. Thrombosis and bleeding in cancer patients. Neth J Med, 1981, 24: 23-35.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Falanga A, Gordon SG. Isolation and characterization of cancer procoagulant: a cysteine proteinase from malignant tissue. Biochemistry, 1985, 24: 5558-5567.</mixed-citation><mixed-citation xml:lang="en">Falanga A, Gordon SG. Isolation and characterization of cancer procoagulant: a cysteine proteinase from malignant tissue. Biochemistry, 1985, 24: 5558-5567.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Agnelli G, Bolis G, Capussotti L, Scarpa RM, Tonelli F, Bonizzoni E, et al. A clinical outcomebased prospective study on venous thromboembolism after cancer surgery: the @RISTOS project. Ann Surg, 2006, 243(1): 89-9545.</mixed-citation><mixed-citation xml:lang="en">Agnelli G, Bolis G, Capussotti L, Scarpa RM, Tonelli F, Bonizzoni E, et al. A clinical outcomebased prospective study on venous thromboembolism after cancer surgery: the @RISTOS project. Ann Surg, 2006, 243(1): 89-9545.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Prandoni P. Antithrombotic strategies in patients with cancer. Thromb Haemost, 1997, 78: 141-4.</mixed-citation><mixed-citation xml:lang="en">Prandoni P. Antithrombotic strategies in patients with cancer. Thromb Haemost, 1997, 78: 141-4.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Levitan N, Dowlati A, Remick S et al. Rates of initial and recurrent thromboembolic disease among patients with malignancy versus those without malignancy. Risk analysis using Medicare claims data. Medicine, 1999, 78: 285-91.</mixed-citation><mixed-citation xml:lang="en">Levitan N, Dowlati A, Remick S et al. Rates of initial and recurrent thromboembolic disease among patients with malignancy versus those without malignancy. Risk analysis using Medicare claims data. Medicine, 1999, 78: 285-91.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Elting LS, Escalante CP, Cooksley C, Avritscher EB, Kurtin D, Hamblin L, et al. Outcomes and cost of deep venous thrombosis among patients with cancer. Arch Intern Med, 2004, 164(15): 1653-61.</mixed-citation><mixed-citation xml:lang="en">Elting LS, Escalante CP, Cooksley C, Avritscher EB, Kurtin D, Hamblin L, et al. Outcomes and cost of deep venous thrombosis among patients with cancer. Arch Intern Med, 2004, 164(15): 1653-61.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Dobesh PP. Economic burden of venous thromboembolism in hospitalized patients. Pharmacotherapy, 2009, 29(8): 943-53.</mixed-citation><mixed-citation xml:lang="en">Dobesh PP. Economic burden of venous thromboembolism in hospitalized patients. Pharmacotherapy, 2009, 29(8): 943-53.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Stein PD, Henry JW. Prevalence of acute pulmonary embolism among patients in a general hospital and at autopsy. Chest, 1995, 108: 978-981.</mixed-citation><mixed-citation xml:lang="en">Stein PD, Henry JW. Prevalence of acute pulmonary embolism among patients in a general hospital and at autopsy. Chest, 1995, 108: 978-981.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mismetti P, Laporte-Simitsidis S, Tardy B, et al. Prevention of venous thromboembolism in internal medicine with unfractionated or lowmolecular- weight heparins: a meta-analysis of randomised clinical trials. Thromb Haemost, 2000, 83: 14-19.</mixed-citation><mixed-citation xml:lang="en">Mismetti P, Laporte-Simitsidis S, Tardy B, et al. Prevention of venous thromboembolism in internal medicine with unfractionated or lowmolecular- weight heparins: a meta-analysis of randomised clinical trials. Thromb Haemost, 2000, 83: 14-19.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Leizorovicz, A, Cohen, AT, Turpie, AGG, et al A randomized placebo controlled trial of dalteparin for the prevention of venous thromboembolism in 3706 acutely ill medical patients: the PREVENT medical thromboprophylaxis study [abstract]. J Thromb Haemost, 2003, 1(suppl): OC396.</mixed-citation><mixed-citation xml:lang="en">Leizorovicz, A, Cohen, AT, Turpie, AGG, et al A randomized placebo controlled trial of dalteparin for the prevention of venous thromboembolism in 3706 acutely ill medical patients: the PREVENT medical thromboprophylaxis study [abstract]. J Thromb Haemost, 2003, 1(suppl): OC396.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen, AT, Davidson, BL, Gallus, AS, et al Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomised placebo controlled trial. BMJ, 2006, 332(7537): 325-9.</mixed-citation><mixed-citation xml:lang="en">Cohen, AT, Davidson, BL, Gallus, AS, et al Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomised placebo controlled trial. BMJ, 2006, 332(7537): 325-9.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Huber O, Bounameux H, Borst F, et al. Postoperative pulmonary embolism after hospital discharge: an underestimated risk. Arch Surg, 1992, 127: 310-313.</mixed-citation><mixed-citation xml:lang="en">Huber O, Bounameux H, Borst F, et al. Postoperative pulmonary embolism after hospital discharge: an underestimated risk. Arch Surg, 1992, 127: 310-313.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Arnesen H, Dahl OE, Aspelin T, Seljeflot I, Kierulf P, Lyberg T: Sustained prothrombotic profile after hip replacement surgery: the influence of prolonged prophylaxis with dalteparin. J Thromb Haemost, 2003 May, 1(5): 971-5.</mixed-citation><mixed-citation xml:lang="en">Arnesen H, Dahl OE, Aspelin T, Seljeflot I, Kierulf P, Lyberg T: Sustained prothrombotic profile after hip replacement surgery: the influence of prolonged prophylaxis with dalteparin. J Thromb Haemost, 2003 May, 1(5): 971-5.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Rasmussen MS. Preventing thromboembolic complications in cancer patients after surgery: a role for prolonged thromboprophylaxis. Cancer Treat Rev, 2002, 28: 141-4.</mixed-citation><mixed-citation xml:lang="en">Rasmussen MS. Preventing thromboembolic complications in cancer patients after surgery: a role for prolonged thromboprophylaxis. Cancer Treat Rev, 2002, 28: 141-4.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Bergqvist D, Agnelli G, Cohen AT et al Duration of prophylaxis against venous thromboembolism with enoxaparin after surgery for cancer. N Engl J Med, 2002, 346: 975- 980.</mixed-citation><mixed-citation xml:lang="en">Bergqvist D, Agnelli G, Cohen AT et al Duration of prophylaxis against venous thromboembolism with enoxaparin after surgery for cancer. N Engl J Med, 2002, 346: 975- 980.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kakkar VV, Balibrea J, Martinez-Gozalez LJ et.al. Extended prophylaxis with bemiparin for the prevention of venous thromboembolism after abdominal or pelvic surgery for cancer: the CANBESURE randomized study. Journal of Thrombosis and Haemostasis, 2010, 8: 1223-1229.</mixed-citation><mixed-citation xml:lang="en">Kakkar VV, Balibrea J, Martinez-Gozalez LJ et.al. Extended prophylaxis with bemiparin for the prevention of venous thromboembolism after abdominal or pelvic surgery for cancer: the CANBESURE randomized study. Journal of Thrombosis and Haemostasis, 2010, 8: 1223-1229.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Levine M, Hirsh J, Gent M, Arnold A, Warr D, Falanga A, et al. Double-blind randomised trial of a very-low-dose warfarin for prevention of thromboembolism in stage IV breast cancer. Lancet, 1994, 343(8902): 886-9.</mixed-citation><mixed-citation xml:lang="en">Levine M, Hirsh J, Gent M, Arnold A, Warr D, Falanga A, et al. Double-blind randomised trial of a very-low-dose warfarin for prevention of thromboembolism in stage IV breast cancer. Lancet, 1994, 343(8902): 886-9.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Agnelli G, Gussoni G, Bianchini C, Verso M, Mandalà M, Cavanna L, et al. Nadroparin for the prevention of thromboembolic events in ambulatory patients with metastatic or locally advanced solid cancer receiving chemotherapy: a randomised, placebo-controlled, double- blind study. Lancet Oncol, 2009, 10(10): 943-9.</mixed-citation><mixed-citation xml:lang="en">Agnelli G, Gussoni G, Bianchini C, Verso M, Mandalà M, Cavanna L, et al. Nadroparin for the prevention of thromboembolic events in ambulatory patients with metastatic or locally advanced solid cancer receiving chemotherapy: a randomised, placebo-controlled, double- blind study. Lancet Oncol, 2009, 10(10): 943-9.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Haas SK, Freund M, Heigener D, Heilmann L, Kemkes-Matthes B, von Tempelhoff GF, et al. Lowmolecular- weight heparin versus placebo for the prevention of venous thromboembolism in metastatic breast cancer or stage III/IV lung cancer. Clin Appl Thromb Hemost, 2012, 18(2): 159-65.</mixed-citation><mixed-citation xml:lang="en">Haas SK, Freund M, Heigener D, Heilmann L, Kemkes-Matthes B, von Tempelhoff GF, et al. Lowmolecular- weight heparin versus placebo for the prevention of venous thromboembolism in metastatic breast cancer or stage III/IV lung cancer. Clin Appl Thromb Hemost, 2012, 18(2): 159-65.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Agnelli G, George DJ, Kakkar AK, Fisher W, Lassen MR, Mismetti P, et al. Semuloparin for thromboprophylaxis in patients receiving chemotherapy for cancer. N Engl J Med, 2012, 366(7): 601-9.</mixed-citation><mixed-citation xml:lang="en">Agnelli G, George DJ, Kakkar AK, Fisher W, Lassen MR, Mismetti P, et al. Semuloparin for thromboprophylaxis in patients receiving chemotherapy for cancer. N Engl J Med, 2012, 366(7): 601-9.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Coughlin RS. Thrombin signaling and proteaseactivated receptors. Nature, 2000, 407: 258-264.</mixed-citation><mixed-citation xml:lang="en">Coughlin RS. Thrombin signaling and proteaseactivated receptors. Nature, 2000, 407: 258-264.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Maragoudakis, ME, Tsopanoglou, NE, Andrio poulou, P Mechanism of thrombin-induced angiogenesis. Biochem Soc Trans, 2002, 30: 173-177.</mixed-citation><mixed-citation xml:lang="en">Maragoudakis, ME, Tsopanoglou, NE, Andrio poulou, P Mechanism of thrombin-induced angiogenesis. Biochem Soc Trans, 2002, 30: 173-177.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Wang A, Templeton DM. Inhibition of mitogenesis and c-fos induction in mesangial cells by heparin and heparan sulfates. Kidney Int, 1996, 49(2): 437-48.</mixed-citation><mixed-citation xml:lang="en">Wang A, Templeton DM. Inhibition of mitogenesis and c-fos induction in mesangial cells by heparin and heparan sulfates. Kidney Int, 1996, 49(2): 437-48.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Collen A, Koolwijk P, Kroon ME, van Hinsbergh VWM. The influence of fibrin structure on the formation and maintenance of capillary-like tubules. Angiogenesis, 1998, 2: 153-165.</mixed-citation><mixed-citation xml:lang="en">Collen A, Koolwijk P, Kroon ME, van Hinsbergh VWM. The influence of fibrin structure on the formation and maintenance of capillary-like tubules. Angiogenesis, 1998, 2: 153-165.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Lee AE, Rogers LA, Jeffery RE and Longcroft J.M. Comparison of metastatic cell lines derived from a murine mammary tumour, and reduction of metastasis by heparin. Clin Exp Metastasis, 1988, 6: 463-471.</mixed-citation><mixed-citation xml:lang="en">Lee AE, Rogers LA, Jeffery RE and Longcroft J.M. Comparison of metastatic cell lines derived from a murine mammary tumour, and reduction of metastasis by heparin. Clin Exp Metastasis, 1988, 6: 463-471.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Massuti B, Lecumberri R, Lopez GM et al. ABEL trial: A phase II randomized trial adding bemiparin (B) to chemo-radiotherapy (CT-RT) in limited- stage small cell lung cancer (SCLC) – Final results. J Clin Oncol, 2012, 30(suppl): abstr 7095.</mixed-citation><mixed-citation xml:lang="en">Massuti B, Lecumberri R, Lopez GM et al. ABEL trial: A phase II randomized trial adding bemiparin (B) to chemo-radiotherapy (CT-RT) in limited- stage small cell lung cancer (SCLC) – Final results. J Clin Oncol, 2012, 30(suppl): abstr 7095.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 2012, 141(2_suppl).</mixed-citation><mixed-citation xml:lang="en">Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 2012, 141(2_suppl).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
