<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2017-6-118-122</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-1896</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Онкоурология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Oncourology</subject></subj-group></article-categories><title-group><article-title>ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ РАДИЯ-223 В ЛЕЧЕНИИ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ</article-title><trans-title-group xml:lang="en"><trans-title>POSSIBILITIES OF RADIUM-223 APPLICATION IN THERAPY OF PROSTATE GLAND CANCER</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ГРИЦКЕВИЧ</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>GRITSKEVICH</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>PhD in medicine</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>МИШУГИН</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>MISHUGIN</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>PhD in medicine</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>РУСАКОВ</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>RUSAKOV</surname><given-names>I. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><bio xml:lang="en"><p>MD, Prof.</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт хирургии им. А.В. Вишневского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Vishnevskiy Institute of Surgery</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Городская клиническая больница №57</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Municipal Clinical Hospital No. 57</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Городская клиническая больница №57&#13;
&#13;
Национальный медицинский исследовательский радиологический центр</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Municipal Clinical Hospital No. 57&#13;
&#13;
National Medical Research and Radiological Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>20</day><month>06</month><year>2017</year></pub-date><volume>0</volume><issue>6</issue><fpage>118</fpage><lpage>122</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; ГРИЦКЕВИЧ А.А., МИШУГИН С.В., РУСАКОВ И.Г., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">ГРИЦКЕВИЧ А.А., МИШУГИН С.В., РУСАКОВ И.Г.</copyright-holder><copyright-holder xml:lang="en">GRITSKEVICH A.A., MISHUGIN S.V., RUSAKOV I.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/1896">https://www.med-sovet.pro/jour/article/view/1896</self-uri><abstract><p>В последние годы было разработано несколько терапевтических вариантов, значительно повышающих выживаемость пациентов с метастатическим кастрационно-резистентным РПЖ (мКРРПЖ). Наличие нескольких активных агентов предоставляет онкологам беспрецедентную возможность адаптировать свой выбор к клиническим характеристикам каждого пациента, к каждой линии лечения, но в то же время создает проблему определения оптимальной терапевтической последовательности для отдельного больного. Вследствие эволюции стратегии лечения, сложности процесса оценки динамики лечения и вариабельности клинических аспектов заболевания мультидисциплинарный подход приобретает сегодня первостепенное значение. В настоящей статье представлены мнения и рекомендации экспертной междисциплинарной группы (Милан, Италия) по использованию радия-223 у мужчин с мКРРПЖ.</p></abstract><trans-abstract xml:lang="en"><p>In recent years several therapeutic options have been developed that significantly improve the survival of patients with metastatic treatment-resistant prostate gland cancer (mCRPC). The presence of several active agents gives oncologists an unprecedented opportunity to adapt their choices to the clinical characteristics of each patient, to each treatment line, but at the same time raises the problem of determining the optimal therapeutic sequence for the individual. Due to evolution of the therapeutic strategy, difficulty of the process of the therapy dynamics evaluation and variability of the clinical disease aspects the multi-disciplinary approach currently acquires the primary importance. This article presents the views and recommendations of the expert of the Interdisciplinary Group (Milan, Italy) on the use of Radium-223 in men with mCRPC.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак предстательной железы</kwd><kwd>радий-223</kwd><kwd>метастатический рак предстательной железы</kwd><kwd>кастрационная резистентность.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Prostate cancer</kwd><kwd>radium-223</kwd><kwd>metastatic cancer prostate</kwd><kwd>castration resistance</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Злокачественные новообразования в России в 2015 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М., 2017: 12-36.</mixed-citation><mixed-citation xml:lang="en">Злокачественные новообразования в России в 2015 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М., 2017: 12-36.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bubendorf L, Schopfer A, Wagner U, Sauter G, Moch H, Willi N et al. 2000. Metastatic patterns of prostate cancer: an autopsy studyof 1,589 patients. Hum. Pathol., 31(5): 578-583.</mixed-citation><mixed-citation xml:lang="en">Bubendorf L, Schopfer A, Wagner U, Sauter G, Moch H, Willi N et al. 2000. Metastatic patterns of prostate cancer: an autopsy studyof 1,589 patients. Hum. Pathol., 31(5): 578-583.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Scher HI, Morris MJ, Basch E, Heller G. End points and outcomes incastration-resistant prostate cancer: from clinical trials to clinical practice. J. Clin. Oncol., 2011, 29(27): 3695-3704.</mixed-citation><mixed-citation xml:lang="en">Scher HI, Morris MJ, Basch E, Heller G. End points and outcomes incastration-resistant prostate cancer: from clinical trials to clinical practice. J. Clin. Oncol., 2011, 29(27): 3695-3704.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Tannock IF, de Wit R, Berry WR, Horti J, Pluzanska A, Chi KN et al. 2004. Docetaxel plus prednisone or mitoxantrone plusprednisone for advanced prostate cancer. N. Engl. J. Med., 351(15): 1502-1512.</mixed-citation><mixed-citation xml:lang="en">Tannock IF, de Wit R, Berry WR, Horti J, Pluzanska A, Chi KN et al. 2004. Docetaxel plus prednisone or mitoxantrone plusprednisone for advanced prostate cancer. N. Engl. J. Med., 351(15): 1502-1512.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I et al. Prednisone plus cabazitaxel or mitoxantrone formetastatic castration- resistant prostate cancer progressing after docetaxeltreatment: a randomised openlabel trial. Lancet, 2010, 376(9747): 1147- 1154.</mixed-citation><mixed-citation xml:lang="en">de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I et al. Prednisone plus cabazitaxel or mitoxantrone formetastatic castration- resistant prostate cancer progressing after docetaxeltreatment: a randomised openlabel trial. Lancet, 2010, 376(9747): 1147- 1154.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Beer TM, Armstrong AJ, Rathkopf DE, Loriot Y, Sternberg CN, Higano CS et al. 2014. Enzalutamidein metastatic prostate cancer before chemotherapy. N. Engl. J. Med., 371(5): 424-433.</mixed-citation><mixed-citation xml:lang="en">Beer TM, Armstrong AJ, Rathkopf DE, Loriot Y, Sternberg CN, Higano CS et al. 2014. Enzalutamidein metastatic prostate cancer before chemotherapy. N. Engl. J. Med., 371(5): 424-433.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">de Bono JS, Logothetis CJ, Molina A, Fizazi K, North S, Chu L et al. Abiraterone and increased survival in metastaticprostate cancer. N. Engl. J. Med., 2011, 364(21): 1995-2005.</mixed-citation><mixed-citation xml:lang="en">de Bono JS, Logothetis CJ, Molina A, Fizazi K, North S, Chu L et al. Abiraterone and increased survival in metastaticprostate cancer. N. Engl. J. Med., 2011, 364(21): 1995-2005.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ryan CJ, Smith MR, de Bono JS, Molina A, Logothetis CJ, de Souza, P et al. 2013. Abiraterone in metastatic prostatecancer without previous chemotherapy. N. Engl. J. Med., 368(2): 138-148.</mixed-citation><mixed-citation xml:lang="en">Ryan CJ, Smith MR, de Bono JS, Molina A, Logothetis CJ, de Souza, P et al. 2013. Abiraterone in metastatic prostatecancer without previous chemotherapy. N. Engl. J. Med., 368(2): 138-148.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Scher HI, Fizazi K, Saad F, Taplin ME, Sternberg CN, Miller K et al. Increased survival with enzalutamide inprostate cancer after chemotherapy. N. Engl. J. Med., 2012, 367(13): 1187-1197.</mixed-citation><mixed-citation xml:lang="en">Scher HI, Fizazi K, Saad F, Taplin ME, Sternberg CN, Miller K et al. Increased survival with enzalutamide inprostate cancer after chemotherapy. N. Engl. J. Med., 2012, 367(13): 1187-1197.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Parker C, Nilsson S, Heinrich D, Helle SI, O’Sullivan JM, Fossa SD et al. Alpha emitter radium-223 and survival inmetastatic prostate cancer. N. Engl. J. Med., 2013, 369(3): 213- 223.</mixed-citation><mixed-citation xml:lang="en">Parker C, Nilsson S, Heinrich D, Helle SI, O’Sullivan JM, Fossa SD et al. Alpha emitter radium-223 and survival inmetastatic prostate cancer. N. Engl. J. Med., 2013, 369(3): 213- 223.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Antonarakis ES, Lu C, Luber B, Wang H, Chen Y, Nakazawa M et al. 2015. Androgenreceptor splice variant 7 and efficacy of taxane chemotherapy in patients withmetastatic castrationresistant prostate cancer. JAMA Oncol., 1(5): 582-591.</mixed-citation><mixed-citation xml:lang="en">Antonarakis ES, Lu C, Luber B, Wang H, Chen Y, Nakazawa M et al. 2015. Androgenreceptor splice variant 7 and efficacy of taxane chemotherapy in patients withmetastatic castrationresistant prostate cancer. JAMA Oncol., 1(5): 582-591.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Antonarakis ES, Lu C, Wang H, Luber B, Nakazawa M, Roeser JC et al. AR-V7 and resistance to enzalutamide andabiraterone in prostate cancer. N Engl J Med, 2014, 371(11): 1028- 1038.</mixed-citation><mixed-citation xml:lang="en">Antonarakis ES, Lu C, Wang H, Luber B, Nakazawa M, Roeser JC et al. AR-V7 and resistance to enzalutamide andabiraterone in prostate cancer. N Engl J Med, 2014, 371(11): 1028- 1038.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Thadani-Mulero M, Portella L, Sun S, Sung M, Matov A, Vessella RL et al. 2014. Androgen receptor splicevariants determine taxane sensitivity in prostate cancer. Cancer Res, 74(8): 2270-2282.</mixed-citation><mixed-citation xml:lang="en">Thadani-Mulero M, Portella L, Sun S, Sung M, Matov A, Vessella RL et al. 2014. Androgen receptor splicevariants determine taxane sensitivity in prostate cancer. Cancer Res, 74(8): 2270-2282.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Caffo O, Lunardi A, Trentin C, Maines F, Veccia A, Galligioni E. Optimalsequencing of new drugs in metastatic castration-resistant prostate cancer: Dream or reality? Curr. Drug Targets, 2016, 17(11): 1301-1308.</mixed-citation><mixed-citation xml:lang="en">Caffo O, Lunardi A, Trentin C, Maines F, Veccia A, Galligioni E. Optimalsequencing of new drugs in metastatic castration-resistant prostate cancer: Dream or reality? Curr. Drug Targets, 2016, 17(11): 1301-1308.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Carrasquillo, JA, O’Donoghue, JA, Pandit-Taskar, N, Humm, JL, Rathkopf, DE, Slovin, SF et al. 2013. Phase I pharmacokinetic and biodistribution study withescalating doses of (2)(2) (3) Ra-dichloride in men with castration-resistantmetastatic prostate cancer. Eur. J. Nucl. Med. Mol. Imaging, 40(9): 1384-1393.</mixed-citation><mixed-citation xml:lang="en">Carrasquillo, JA, O’Donoghue, JA, Pandit-Taskar, N, Humm, JL, Rathkopf, DE, Slovin, SF et al. 2013. Phase I pharmacokinetic and biodistribution study withescalating doses of (2)(2) (3) Ra-dichloride in men with castration-resistantmetastatic prostate cancer. Eur. J. Nucl. Med. Mol. Imaging, 40(9): 1384-1393.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Suominen MI, Rissanen JP, Kakonen R, Fagerlund KM, Alhoniemi E, Mumberg D et al. Survival benefit with radium-223 dichloride in a mouse model of breast cancerbone metastasis. J. Natl. Cancer Inst., 2013, 105(12): 908-916.</mixed-citation><mixed-citation xml:lang="en">Suominen MI, Rissanen JP, Kakonen R, Fagerlund KM, Alhoniemi E, Mumberg D et al. Survival benefit with radium-223 dichloride in a mouse model of breast cancerbone metastasis. J. Natl. Cancer Inst., 2013, 105(12): 908-916.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Sartor O, Coleman R, Nilsson S, Heinrich D, Helle SI, O’Sullivan JM et al. Effect of radium- 223 dichlorideon symptomatic skeletal events in patients with castration-resistant prostatecancer and bone metastases: results from a phase 3, double-blind, randomisedtrial. Lancet Oncol., 2014, 15(7): 738-746.</mixed-citation><mixed-citation xml:lang="en">Sartor O, Coleman R, Nilsson S, Heinrich D, Helle SI, O’Sullivan JM et al. Effect of radium- 223 dichlorideon symptomatic skeletal events in patients with castration-resistant prostatecancer and bone metastases: results from a phase 3, double-blind, randomisedtrial. Lancet Oncol., 2014, 15(7): 738-746.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hoskin, P, Sartor, O, O’Sullivan, JM, Johannessen, DC, Helle, SI, Logue, J,Bottomley, D et al. 2014. Efficacy and safety of radium-223 dichloride in patients withcastration-resistant prostate cancer and symptomatic bone metastases, withor without previous docetaxel use: a prespecified subgroup analysis from therandomised, double- blind, phase 3 ALSYMPCA trial. Lancet Oncol., 15(12): 1397-1406.</mixed-citation><mixed-citation xml:lang="en">Hoskin, P, Sartor, O, O’Sullivan, JM, Johannessen, DC, Helle, SI, Logue, J,Bottomley, D et al. 2014. Efficacy and safety of radium-223 dichloride in patients withcastration-resistant prostate cancer and symptomatic bone metastases, withor without previous docetaxel use: a prespecified subgroup analysis from therandomised, double- blind, phase 3 ALSYMPCA trial. Lancet Oncol., 15(12): 1397-1406.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Nilsson S, Tomblyn M, Cislo P. Patient-reported quality of life analysis ofradium-223 dichloride evaluating pain relief from the phase 3 ALSYMPCAstudy. J. Clin. Oncol., 2014, 32: 5069, Abstract.</mixed-citation><mixed-citation xml:lang="en">Nilsson S, Tomblyn M, Cislo P. Patient-reported quality of life analysis ofradium-223 dichloride evaluating pain relief from the phase 3 ALSYMPCAstudy. J. Clin. Oncol., 2014, 32: 5069, Abstract.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Cislo P, Sartor AO, Reuning-Scherer J. Effects of radium-223 dichloride onhealth-related quality of life assessed by the EQ-5D utility scores inALSYMPCA. Eur. Urol., 2015, 14: e673- e773.</mixed-citation><mixed-citation xml:lang="en">Cislo P, Sartor AO, Reuning-Scherer J. Effects of radium-223 dichloride onhealth-related quality of life assessed by the EQ-5D utility scores inALSYMPCA. Eur. Urol., 2015, 14: e673- e773.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Nilsson S, Cislo P, Sartor O, Vogelzang NJ, Coleman RE, O’Sullivan JM et al. Patientreportedquality- of-life analysis of radium-223 dichloride from the phase III ALSYMPCAstudy. Ann. Oncol., 2016, 27(5): 868-874.</mixed-citation><mixed-citation xml:lang="en">Nilsson S, Cislo P, Sartor O, Vogelzang NJ, Coleman RE, O’Sullivan JM et al. Patientreportedquality- of-life analysis of radium-223 dichloride from the phase III ALSYMPCAstudy. Ann. Oncol., 2016, 27(5): 868-874.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Sartor, AO, Fernandez, DC, Morris, MJ, Iagaru, A, Brown, A, Almeida, F, et al. 2015a. Ra- 223 experience in pretreated patients: EAP setting. J. Clin. Oncol. 33 (Suppl): 5063, Abstract.</mixed-citation><mixed-citation xml:lang="en">Sartor, AO, Fernandez, DC, Morris, MJ, Iagaru, A, Brown, A, Almeida, F, et al. 2015a. Ra- 223 experience in pretreated patients: EAP setting. J. Clin. Oncol. 33 (Suppl): 5063, Abstract.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Saad F, Keizman D, O’Sullivan JM, Carles J, Wirth M, Gillessen S et al. Analysis ofoverall survival by number of radium-223 injections received in aninternational expanded access program (iEAP). Clin. Oncol., 2016, 34(15 suppl): 5082, abstract.</mixed-citation><mixed-citation xml:lang="en">Saad F, Keizman D, O’Sullivan JM, Carles J, Wirth M, Gillessen S et al. Analysis ofoverall survival by number of radium-223 injections received in aninternational expanded access program (iEAP). Clin. Oncol., 2016, 34(15 suppl): 5082, abstract.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Graff JN, Beer TM. Pharmacotherapeutic management of metastatic,castration- resistant prostate cancer in the elderly: focus on nonchemotherapyagents. Drugs Aging, 2014, 31(12): 873-882.</mixed-citation><mixed-citation xml:lang="en">Graff JN, Beer TM. Pharmacotherapeutic management of metastatic,castration- resistant prostate cancer in the elderly: focus on nonchemotherapyagents. Drugs Aging, 2014, 31(12): 873-882.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Sartor AO, Heinrich D, Mariados N, Radium-223 (Ra-223) re-treatment(Re-tx): First experience from an international, multicenter, prospective studyin patients (Pts) with castration-resistant prostate cancer and bone metastases(mCRPC). J. Clin. Oncol., 2016, 34(Suppl 2S): 197, Abstract.</mixed-citation><mixed-citation xml:lang="en">Sartor AO, Heinrich D, Mariados N, Radium-223 (Ra-223) re-treatment(Re-tx): First experience from an international, multicenter, prospective studyin patients (Pts) with castration-resistant prostate cancer and bone metastases(mCRPC). J. Clin. Oncol., 2016, 34(Suppl 2S): 197, Abstract.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Fizazi K, Massard C, Smith M, Rader M, Brown J, Milecki P et al. Bone-related parameters are the main prognostic factors for overall survival inmen with bone metastases from castrationresistant prostate cancer. Eur. Urol., 2015, 68(1): 42-50.</mixed-citation><mixed-citation xml:lang="en">Fizazi K, Massard C, Smith M, Rader M, Brown J, Milecki P et al. Bone-related parameters are the main prognostic factors for overall survival inmen with bone metastases from castrationresistant prostate cancer. Eur. Urol., 2015, 68(1): 42-50.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Sartor AO, Amariglio R, Wilhelm S, Garcia-Vargas J, O’Bryan-Tear CG, Shan M et al. Correlation between baseline variables andsurvival in the radium-223 dichloride (Ra-223) phase III ALSYMPCA trial withattention to total ALP changes. J. Clin. Oncol., 2013, 31(15 Suppl): 5080.</mixed-citation><mixed-citation xml:lang="en">Sartor AO, Amariglio R, Wilhelm S, Garcia-Vargas J, O’Bryan-Tear CG, Shan M et al. Correlation between baseline variables andsurvival in the radium-223 dichloride (Ra-223) phase III ALSYMPCA trial withattention to total ALP changes. J. Clin. Oncol., 2013, 31(15 Suppl): 5080.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Nilsson S, Franzen L, Parker C, Tyrrell C, Blom R, Tennvall J et al. Bone-targetedradium- 223 in symptomatic, hormone-refractory prostate cancer: arandomised, multicentre, placebo-controlled phase II study. Lancet Oncol., 2007, 8(7): 587-594.</mixed-citation><mixed-citation xml:lang="en">Nilsson S, Franzen L, Parker C, Tyrrell C, Blom R, Tennvall J et al. Bone-targetedradium- 223 in symptomatic, hormone-refractory prostate cancer: arandomised, multicentre, placebo-controlled phase II study. Lancet Oncol., 2007, 8(7): 587-594.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Nome R, Hernes E, Bogsrud TV, Bjoro T, Fossa SD, Changes inprostate-specific antigen, markers of bone metabolism and bone scans aftertreatment with radium-223. Scand. J. Urol., 2015, 49(3): 211-217.</mixed-citation><mixed-citation xml:lang="en">Nome R, Hernes E, Bogsrud TV, Bjoro T, Fossa SD, Changes inprostate-specific antigen, markers of bone metabolism and bone scans aftertreatment with radium-223. Scand. J. Urol., 2015, 49(3): 211-217.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Etchebehere EC, Milton DR, Araujo JC, Swanston NM, Macapinlac HA, Rohren EM. Factors affecting (223)Ra therapy: clinical experienceafter 532 cycles from a single institution. Eur. J. Nucl. Med. Mol. Imaging, 2016, 43(1): 8-20.</mixed-citation><mixed-citation xml:lang="en">Etchebehere EC, Milton DR, Araujo JC, Swanston NM, Macapinlac HA, Rohren EM. Factors affecting (223)Ra therapy: clinical experienceafter 532 cycles from a single institution. Eur. J. Nucl. Med. Mol. Imaging, 2016, 43(1): 8-20.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kelloff GJ, Coffey DS, Chabner BA, Dicker AP, Guyton KZ, Nisen PD et al. Prostate- specific antigen doubling time as asurrogate marker for evaluation of oncologic drugs to treat prostate cancer. Clin. Cancer Res., 2004, 10(11): 3927-3933.</mixed-citation><mixed-citation xml:lang="en">Kelloff GJ, Coffey DS, Chabner BA, Dicker AP, Guyton KZ, Nisen PD et al. Prostate- specific antigen doubling time as asurrogate marker for evaluation of oncologic drugs to treat prostate cancer. Clin. Cancer Res., 2004, 10(11): 3927-3933.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Parker C, Finkelstein SE, Michalski JM, O’Sullivan JM, Bruland O, Vogelzang NJ et al. Efficacy and safety of radium-223 dichloride in symptomaticcastration-resistant prostate cancer patients with or without baseline opioiduse from the phase 3 ALSYMPCA trial. Eur. Urol., 2016, 70(5): 875–883.</mixed-citation><mixed-citation xml:lang="en">Parker C, Finkelstein SE, Michalski JM, O’Sullivan JM, Bruland O, Vogelzang NJ et al. Efficacy and safety of radium-223 dichloride in symptomaticcastration-resistant prostate cancer patients with or without baseline opioiduse from the phase 3 ALSYMPCA trial. Eur. Urol., 2016, 70(5): 875–883.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Sartor AO, Fernandez DC, Morris MJ, Iagaru A, Brown A, Almeida et al. Radium-223 dichloride experience inpretreated patients: early access program. J. Clin. Oncol., 2015, 31(Suppl): 5068, Abstract.</mixed-citation><mixed-citation xml:lang="en">Sartor AO, Fernandez DC, Morris MJ, Iagaru A, Brown A, Almeida et al. Radium-223 dichloride experience inpretreated patients: early access program. J. Clin. Oncol., 2015, 31(Suppl): 5068, Abstract.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Morris MJ, Higano CS, Scher H, Sweeney C, Antonarakis ES, Shevrin DH et al. Effects of radium-223 dichloride(Ra-223) with docetaxel (D) versus D on prostate-specific antigen (PSA) andbone alkaline phosphatase (bALP) in patients (pts) with castration- resistantprostate cancer (CRPC) and bone metastases (mets): A phase 1/2a clinical trial. J. Clin. Oncol., 2015, 34(Supply 7): 202, Abstract.</mixed-citation><mixed-citation xml:lang="en">Morris MJ, Higano CS, Scher H, Sweeney C, Antonarakis ES, Shevrin DH et al. Effects of radium-223 dichloride(Ra-223) with docetaxel (D) versus D on prostate-specific antigen (PSA) andbone alkaline phosphatase (bALP) in patients (pts) with castration- resistantprostate cancer (CRPC) and bone metastases (mets): A phase 1/2a clinical trial. J. Clin. Oncol., 2015, 34(Supply 7): 202, Abstract.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Sartor O, Hoskin P, Coleman RE, Nilsson S, Vogelzang NJ, Petrenciuc O, et al. Chemotherapy followingradium-223 dichloride treatment in ALSYMPCA. Prostate, 2016, 76(10): 905-916.</mixed-citation><mixed-citation xml:lang="en">Sartor O, Hoskin P, Coleman RE, Nilsson S, Vogelzang NJ, Petrenciuc O, et al. Chemotherapy followingradium-223 dichloride treatment in ALSYMPCA. Prostate, 2016, 76(10): 905-916.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
