medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-6-124-131medsovet-1897Research ArticleОНКОГЕМАТОЛОГИЯONCOHEMATOLOGYДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА ЛИМФОМ СРЕДОСТЕНИЯ: ВЗГЛЯД ОНКОЛОГА И ПАТОЛОГАDIFFERENTIAL DIAGNOSIS OF LYMPHOMAS OF THE MEDIASTINUM: A VIEW OF THE ONCOLOGIST AND PATHOLOGISTХАРЧЕНКОЕ. В.KHARCHENKOE. V.АРТЕМЬЕВАА. С.ARTEMYEVAA. S.

к.м.н.

PhD in medicine

СЕМИГЛАЗОВАТ. Ю.SEMIGLAZOVAT. Y.

д.м.н., профессор

MD, Prof.

КЛИМАШЕВСКИЙВ. Ф.KLIMASHEVSKYV. F.

к.м.н.

PhD in medicine

АЛЕКСЕЕВС. М.ALEXEEVS. M.

к.м.н.

PhD in medicine

ЗЮЗГИНИ. С.ZYUZGINI. S.

к.м.н.

PhD in medicine

ФИЛАТОВАЛ. В.FILATOVAL. V.

д.м.н.

MD

МОТАЛКИНАМ. С.MOTALKINAM. S.

к.м.н.

СЕМИГЛАЗОВВ. В.SEMIGLAZOVV. V.

д.м.н., профессор, чл.-корр. РАН

MD, Prof., Corresponding member of RAS

ЧУДИНОВСКИХЮ. А.CHUDINOVSKYY. A.ЗВЯГИНЦЕВАД. А.ZVYAGINTSEVAD. A.ХАДОНОВУ. Б.KHADONOVU. B.ШИЛОП. С.SHILOP. S.КУШНАРЕВВ. А.KUSHNAREVV. A.КОСИЧКИНАА. Б.KOSICHKINAA. B.Научно-исследовательский институт онкологии им. Н.Н. Петрова Минздрава РоссииРоссияPetrov Research Institute of Oncology, St. PetersburgRussian FederationНаучно-исследовательский институт онкологии им. Н.Н. Петрова Минздрава России Северо-Западный государственный медицинский университет им. И.И. Мечникова Минздрава РоссииРоссияPetrov Research Institute of Oncology, St. Petersburg Mechnikov North-Western State Medical University of the Ministry of Health of RussiaRussian FederationНаучно-исследовательский институт онкологии им. Н.Н. Петрова Минздрава России Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова Минздрава РоссииРоссияPetrov Research Institute of Oncology, St. Petersburg Pavlov First Saint-Petersburg State Medical UniversityRussian Federation20172006201706124131Copyright © ХАРЧЕНКО Е.В., АРТЕМЬЕВА А.С., СЕМИГЛАЗОВА Т.Ю., КЛИМАШЕВСКИЙ В.Ф., АЛЕКСЕЕВ С.М., ЗЮЗГИН И.С., ФИЛАТОВА Л.В., МОТАЛКИНА М.С., СЕМИГЛАЗОВ В.В., ЧУДИНОВСКИХ Ю.А., ЗВЯГИНЦЕВА Д.А., ХАДОНОВ У.Б., ШИЛО П.С., КУШНАРЕВ В.А., КОСИЧКИНА А.Б., 20172017ХАРЧЕНКО Е.В., АРТЕМЬЕВА А.С., СЕМИГЛАЗОВА Т.Ю., КЛИМАШЕВСКИЙ В.Ф., АЛЕКСЕЕВ С.М., ЗЮЗГИН И.С., ФИЛАТОВА Л.В., МОТАЛКИНА М.С., СЕМИГЛАЗОВ В.В., ЧУДИНОВСКИХ Ю.А., ЗВЯГИНЦЕВА Д.А., ХАДОНОВ У.Б., ШИЛО П.С., КУШНАРЕВ В.А., КОСИЧКИНА А.Б.KHARCHENKO E.V., ARTEMYEVA A.S., SEMIGLAZOVA T.Y., KLIMASHEVSKY V.F., ALEXEEV S.M., ZYUZGIN I.S., FILATOVA L.V., MOTALKINA M.S., SEMIGLAZOV V.V., CHUDINOVSKY Y.A., ZVYAGINTSEVA D.A., KHADONOV U.B., SHILO P.S., KUSHNAREV V.A., KOSICHKINA A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/1897

В данной статье рассмотрена дифференциальная диагностика клинических, патоморфологических и иммуногистохимических особенностей различных типов лимфом средостения с точки зрения онколога и патолога. При изолированном поражении органов средостения клинико-рентгенологическая диагностика затруднена, только развернутый гистологический диагноз позволяет определиться с тактикой и подобрать эффективную терапию. Образования средостения часто выявляются у лиц молодого трудоспособного возраста, и большинство из них – лимфопролиферативные заболевания. Спектр лимфом, возникающих в средостении, широк, чаще всего это крупноклеточные В-клеточные лимфомы, к которым помимо лимфомы Ходжкина относятся первичная медиастинальная крупноклеточная В- клеточная лимфома, диффузная крупноклеточная В-клеточная лимфома и медиастинальная лимфома серой зоны. Кроме того, в средостении могут возникать другие В-клеточные индолентные неходжкинские лимфомы и Т-клеточные лимфомы.

The clinic-rentgenological differential diagnosis is difficult especially in case of localized mediastinal disease. Just detailed histological diagnosis allows making a right tactic decision and choosing effective therapy. Furthermore, some indolent B-cell lymphomas and T-cell lymphomas can arise in mediastinum. Mediastinal tumors are frequent in young adults, and most of these neoplasms are lymphoproliferative disorders. The spectrum of mediastinal lymphoma is broad. The most often of them are large B-cell lymphomas: classical Hodgkin lymphoma, primary mediastinal large B-cell lymphoma, diffuse large B-cell lymphoma and mediastinal grey zone lymphoma.

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The authors declare that there are no conflicts of interest present.