medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-13-150-156medsovet-1999Research ArticleРепродуктивное здоровье и ВРТReproductive health and ARTОКИСЛИТЕЛЬНЫЙ СТРЕСС АНТИОКСИДАНТНАЯ ТЕРАПИЯ ПРИ ПРЕГРАВИДАРНОЙ ПОДГОТОВКЕ И/ИЛИ ПРИ БOXIDIZING STRESS ANTIOXIDANT THERAPY IN PREGRAVIDAR TRAINING AND/OR INFERTILITYСыркашеваА. Г.SyrkashevaA. G.

к.м.н.,

Москва

PhD in medicine,

Moscow

КоротченкоО. Е.KorotchenkoO. E.

Москва

Moscow

Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В. И. Кулакова Минздрава РоссииРоссияKulakov Scientific Center for Obstetrics, Gynaecology and Perinatology of the Ministry of Health of RussiaRussian Federation201709102017013150156Copyright © Сыркашева А.Г., Коротченко О.Е., 20172017Сыркашева А.Г., Коротченко О.Е.Syrkasheva A.G., Korotchenko O.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/1999

В течение последних нескольких десятилетий распространенность бесплодия и субфертильности значительно увеличилась, в первую очередь в развитых странах. Факторы внешней среды, такие как загрязнение воздуха и почвы, контакт с различными химикатами, рассматриваются в качестве причины снижения как женской, так и мужской фертильности. Различные факторы образа жизни, такие как питание, наличие хронических заболеваний, стрессы, аллергия, курение и употребление алкоголя, – также рассматриваются как потенциальные причины снижения фертильности.

Токсическое воздействие различных вредных веществ на репродуктивную систему человека может приводить к нарушению синтеза стероидных гормонов, а также к прямому повреждению тканей репродуктивных органов. Известно, что основным патофизиологическим механизмом негативного влияния токсических веществ на репродукцию является развитие окислительного стресса – важного компонента различных серьезных заболеваний человека.

Антиоксиданты — группа лекарственных препаратов, которые нейтрализуют свободные радикалы. К антиоксидантам относятся различные витамины, минералы, а также полиненасыщенные жирные кислоты. Различные антиоксиданты (в виде биологически активных добавок) и поливитамины часто назначаются в качестве прегравидарной подготовки женщинам и мужчинам, планирующим естественную беременность и испытывающим трудности с зачатием, или пациентам на этапе подготовки к программе вспомогательных репродуктивных технологий (ВРТ). Целью назначения препаратов является увеличение фертильности и повышение эффективности программы ВРТ, однако эффективность подобной терапии окончательно не определена. В данном обзоре литературы представлены современные данные литературы относительно влияния витаминов А, С, Е, омега-3 полиненасыщенных жирных кислот, мелатонина и кофермента Q10 на различные аспекты репродуктивной функции человека. 

Over the past few decades the incidence of infertility and sub-fertility has increased significantly, particularly in developed countries. External environmental factors, such as air and soil pollution, contact with different chemicals, are consdiered as the cause of both female and male fertility decline. Various lifestyle factors, such as nutrition, chronic diseases, stress, allergies, smoking and alcohol consumption, are also seen as potential causes of fertility decline.

The toxic effects of various harmful substances on a reproductive human system can lead to a disruption of the synthesis of steroid hormones, as well as to the direct damage to the tissue of reproductive organs. It is known that the main pathological mechanism for the negative effects of toxic substances on reproduction is the development of oxidized stress, an important component of various serious human diseases.

Antioxidants are a group of medications that neutralize the free radicals. Antioxidants include various vitamins, minerals, as well as polyunsaturated fatty acids. Various antioxidants (in the form of biologically active additives) and multivitamins are often indicated as preconception training for women and men who are planning a natural pregnancy and are experiencing a fertility problem or patients in the preparation for the program of auxiliary reproductive technologies (ART). The purpose of the drugs is to increase fertility and increase the effectiveness of the ART program, but the efficacy of such therapy has not been definitively defined.

This literature review provides the up-to-date literature data on the effects of vitamin A, C, E, omega-3-polyunsaturated fatty acids, melatonin and the Q10 coenzyme on various aspects of the human reproduction function. 

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The authors declare that there are no conflicts of interest present.