<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2017-18-102-106</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2040</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Рациональная фармакотерапия</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Rational pharmacotherapy</subject></subj-group></article-categories><title-group><article-title>КОМПЛЕКСНЫЙ ПОДХОД К ТЕРАПИИ ОСТРЫХ И ХРОНИЧЕСКИХ ЗАБОЛЕВАНИЙ ОРГАНОВ ДЫХАНИЯ</article-title><trans-title-group xml:lang="en"><trans-title>COMPLEX APPROACH TO THERAPY OF ACUTE AND CHRONIC DIEASES OF RESPIRATORY ORGANS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Визель</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Visel</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><bio xml:lang="en"><p>MD, Prof.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Визель</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Visel</surname><given-names>I. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>PhD in medicine</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гизатуллина</surname><given-names>Э. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Gizatullina</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н</p></bio><bio xml:lang="en"><p>PhD in medicine</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Казанский государственный медицинский университет Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kazan State Medical University of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>03</day><month>11</month><year>2017</year></pub-date><volume>0</volume><issue>18</issue><fpage>102</fpage><lpage>106</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Визель А.А., Визель И.Ю., Гизатуллина Э.Д., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Визель А.А., Визель И.Ю., Гизатуллина Э.Д.</copyright-holder><copyright-holder xml:lang="en">Visel A.A., Visel I.Y., Gizatullina E.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2040">https://www.med-sovet.pro/jour/article/view/2040</self-uri><abstract><p>Представлен обзор зарубежной и отечественной литературы, посвященной применению фитопрепарата Миртол, который представляет собой оригинальный растительный комплекс, стандартизированный по содержанию трех компонентов: d-лимонена, 1,8-цинеола, α-пинена. Клиническая эффективность Миртола стандартизированного была доказана в лечении острого и хронического риносинусита, острого и хронического бронхита и хронической обструктивной болезни легких (ХОБЛ). Исследования показали, что препарат обладает широким фармакодинамическим профилем действия (муколитический, секретолитический, секретомоторный, антиоксидантный, противовоспалительный и антибактериальный эффекты) при высоком уровне безопасности.</p><p> </p></abstract><trans-abstract xml:lang="en"><p>A review of the foreign and Russian literature devoted to application of the herbal medicine Myrtol standardized, an original vegetative complex standardized by the content of three components: d-limonen, 1,8-cyneol, α-pinene. The clinical effectiveness of the standardized Myrtol was proved in the therapy of acute and chronic rhinosinusitis, acute and chronic bronchitis and chronic obstructive lung disease (COPD). The studies showed that the drug has a wide pharmacodynamic profile of action (mycolytic, secretolytic, secretomotor, antioxidant, anti-inflammatory and antibacterial effects) with high safety profie.</p><p> </p></trans-abstract><kwd-group xml:lang="ru"><kwd>Миртол стандартизированный</kwd><kwd>ГелоМиртол®</kwd><kwd>ГелоМиртол® форте</kwd><kwd>фитопрепарат</kwd><kwd>синусит</kwd><kwd>риносинусит</kwd><kwd>бронхит</kwd><kwd>хроническая обструктивная болезнь легких</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Myrtol standardized</kwd><kwd>GeloMyrtol®</kwd><kwd>GeloMyrtol® Forte</kwd><kwd>herbal medicine</kwd><kwd>sinusitis</kwd><kwd>rhinosinusitis</kwd><kwd>bronchitis</kwd><kwd>chronic obstructive lung disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Чучалин А.Г., Авдеев С.Н., Айсанов З.Р., Белевский А.С., Лещенко И.В., Мещерякова Н.Н., Овчаренко С.И., Шмелёв Е.И. Российское респираторное общество: Федеральные клинические рекомендации по диагностике и лечению хронической обструктивной болезни легких. Пульмонология, 2014, 3: 16-36.</mixed-citation><mixed-citation xml:lang="en">Чучалин А.Г., Авдеев С.Н., Айсанов З.Р., Белевский А.С., Лещенко И.В., Мещерякова Н.Н., Овчаренко С.И., Шмелёв Е.И. Российское респираторное общество: Федеральные клинические рекомендации по диагностике и лечению хронической обструктивной болезни легких. Пульмонология, 2014, 3: 16-36.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (GOLD): 2017 report 2017: 123 p. www.coldcopd.prg.</mixed-citation><mixed-citation xml:lang="en">Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (GOLD): 2017 report 2017: 123 p. www.coldcopd.prg.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Behrbohm H, Kaschke O, Sydow K. Effect of the phytogenic secretolytic drug Gelomyrtol forte on mucociliary clearance of the maxillary sinus. Laryngorhinootologie, 1995, 74: 733-737.</mixed-citation><mixed-citation xml:lang="en">Behrbohm H, Kaschke O, Sydow K. Effect of the phytogenic secretolytic drug Gelomyrtol forte on mucociliary clearance of the maxillary sinus. Laryngorhinootologie, 1995, 74: 733-737.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmermann T, Seiberling M, Thomann P, Karabelnik D. The relative bioavailability and pharmacokinetics of standardized myrtol. Arzneimittelforschung. 1995; 45: 1198–1201.</mixed-citation><mixed-citation xml:lang="en">Zimmermann T, Seiberling M, Thomann P, Karabelnik D. The relative bioavailability and pharmacokinetics of standardized myrtol. Arzneimittelforschung. 1995; 45: 1198–1201.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Grassmann J, Hipelli S, Dornisch K, Rohnert U, Beuscher N, Elstner EF. Antioxidant Properties Of Essential Oils. Possible explanations for their anti-inflammatory effects. Arzneimittelforschung, 2000, 50(02): 135-139.</mixed-citation><mixed-citation xml:lang="en">Grassmann J, Hipelli S, Dornisch K, Rohnert U, Beuscher N, Elstner EF. Antioxidant Properties Of Essential Oils. Possible explanations for their anti-inflammatory effects. Arzneimittelforschung, 2000, 50(02): 135-139.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Beuscher N, Keitzmann M, Bien E, Champeroux P. Interference of Myrtol standardized with inflammatory and allergic mediators. Arzneimittelforschung, 1998, (48): 985-989.</mixed-citation><mixed-citation xml:lang="en">Beuscher N, Keitzmann M, Bien E, Champeroux P. Interference of Myrtol standardized with inflammatory and allergic mediators. Arzneimittelforschung, 1998, (48): 985-989.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Beeh KM, Beier J, Candler H, Wittig T. Effect of ELOM-080 on exacerbations and symptoms in COPD patients with a chronic bronchitis phenotype – a post-hoc analysis of a randomized, double-blind, placebo-controlled clinical trial. Int. J. Chron. Obstruct. Pulmon. Dis., 2016, 11: 2877-2884.</mixed-citation><mixed-citation xml:lang="en">Beeh KM, Beier J, Candler H, Wittig T. Effect of ELOM-080 on exacerbations and symptoms in COPD patients with a chronic bronchitis phenotype – a post-hoc analysis of a randomized, double-blind, placebo-controlled clinical trial. Int. J. Chron. Obstruct. Pulmon. Dis., 2016, 11: 2877-2884.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Federspil P, Wulkow R, Zimmermann T. Effects of standardized Myrtol in therapy of acute sinusitis – Results of a double-blind, randomized multicenter study compared with placebo. Laryngorhinootologie, 1997, 76: 23–27.</mixed-citation><mixed-citation xml:lang="en">Federspil P, Wulkow R, Zimmermann T. Effects of standardized Myrtol in therapy of acute sinusitis – Results of a double-blind, randomized multicenter study compared with placebo. Laryngorhinootologie, 1997, 76: 23–27.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Виттиг Т. Миртол стандартизированный. Клиническая документация, Россия, 2009, 1-е издание, ISBN 3-8796-071-6: 22-44.</mixed-citation><mixed-citation xml:lang="en">Виттиг Т. Миртол стандартизированный. Клиническая документация, Россия, 2009, 1-е издание, ISBN 3-8796-071-6: 22-44.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lai Y, Dilidaer D, Chen B, Xu G, Shi J, Lee RJ, Cohen NA. In vitro studies of a distillate of rectified essential oils on sinonasal components of mucociliary clearance. American journal of rhinology and allergy, 2014, 28(3): 244-248.</mixed-citation><mixed-citation xml:lang="en">Lai Y, Dilidaer D, Chen B, Xu G, Shi J, Lee RJ, Cohen NA. In vitro studies of a distillate of rectified essential oils on sinonasal components of mucociliary clearance. American journal of rhinology and allergy, 2014, 28(3): 244-248.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Christoph F, Kaulfers P, Stahl-Biskup E. In vitro Evaluation of the Antibacterial Activity of -Triketones Admixed to Melaleuca Oils. Planta Med, 2001, 67(08): 768-771.</mixed-citation><mixed-citation xml:lang="en">Christoph F, Kaulfers P, Stahl-Biskup E. In vitro Evaluation of the Antibacterial Activity of -Triketones Admixed to Melaleuca Oils. Planta Med, 2001, 67(08): 768-771.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">De Mey C, Riechelmann H. A Multi-centre, randomised, placebo-controlled, double-blind, repeateddose, parallel group study to assess the efficacy and tolerability of Myrtol in patients with chronic sinusitis. P9806GF. Köhne-Volland R. Addendum zur Konfirmatorischen Datenanalyse, Myrtol Standardisiert Dokumentation. 2008 German.</mixed-citation><mixed-citation xml:lang="en">De Mey C, Riechelmann H. A Multi-centre, randomised, placebo-controlled, double-blind, repeateddose, parallel group study to assess the efficacy and tolerability of Myrtol in patients with chronic sinusitis. P9806GF. Köhne-Volland R. Addendum zur Konfirmatorischen Datenanalyse, Myrtol Standardisiert Dokumentation. 2008 German.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Matthys H, de Mey C, Carls C, Rys A, Geib A, Wittig T. Efficacy and tolerability of myrtol standardized in acute bronchitis A multi-centre, randomised, double-blind, placebo-controlled parallel group clinical trial vs cefuroxime and ambroxol. Arzneimittelforschung, 2000, 50: 700–711.</mixed-citation><mixed-citation xml:lang="en">Matthys H, de Mey C, Carls C, Rys A, Geib A, Wittig T. Efficacy and tolerability of myrtol standardized in acute bronchitis A multi-centre, randomised, double-blind, placebo-controlled parallel group clinical trial vs cefuroxime and ambroxol. Arzneimittelforschung, 2000, 50: 700–711.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Gillissen A, Wittig T, Ehmen M, Krezdorn HG, de Mey C. A multi-centre, randomised, double-blind, placebo-controlled clinical trial on the efficacy and tolerability of GeloMyrtol® forte in acute bronchitis. Drug Res (Stuttg), 2013, 63: 19–27.</mixed-citation><mixed-citation xml:lang="en">Gillissen A, Wittig T, Ehmen M, Krezdorn HG, de Mey C. A multi-centre, randomised, double-blind, placebo-controlled clinical trial on the efficacy and tolerability of GeloMyrtol® forte in acute bronchitis. Drug Res (Stuttg), 2013, 63: 19–27.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Meister R, Wittig T, Beuscher N, de Mey C. Efficacy and tolerability of myrtol standardized in longterm treatment of chronic bronchitis. A double-blind, placebo-controlled study Study Group Investigators. Arzneimittelforschung, 1999, 49: 351–358.</mixed-citation><mixed-citation xml:lang="en">Meister R, Wittig T, Beuscher N, de Mey C. Efficacy and tolerability of myrtol standardized in longterm treatment of chronic bronchitis. A double-blind, placebo-controlled study Study Group Investigators. Arzneimittelforschung, 1999, 49: 351–358.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Poole P, Chong J, Cates CJ. Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database Syst Rev, 2015, 7: CD001287. doi: 10.1002/14651858.CD001287.pub5.</mixed-citation><mixed-citation xml:lang="en">Poole P, Chong J, Cates CJ. Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database Syst Rev, 2015, 7: CD001287. doi: 10.1002/14651858.CD001287.pub5.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Beeh KM, Beier J, Candler H, Wittig T. Effect of ELOM-080 on exacerbations and symptoms in COPD patients with a chronic bronchitis phenotype – a post-hoc analysis of a randomized, double-blind, placebo-controlled clinical trial. Int. J. Chron. Obstruct. Pulmon. Dis., 2016, 11: 2877-2884.</mixed-citation><mixed-citation xml:lang="en">Beeh KM, Beier J, Candler H, Wittig T. Effect of ELOM-080 on exacerbations and symptoms in COPD patients with a chronic bronchitis phenotype – a post-hoc analysis of a randomized, double-blind, placebo-controlled clinical trial. Int. J. Chron. Obstruct. Pulmon. Dis., 2016, 11: 2877-2884.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Rantzsch U, Vacca G, Dück R, Gillissen A. Anti-inflammatory effects of Myrtol tandardized and other essential oils on alveolar macrophages from patients with chronic obstructive pulmonary disease. Eur J Med Res, 2009, 14(Suppl 4): 205–209.</mixed-citation><mixed-citation xml:lang="en">Rantzsch U, Vacca G, Dück R, Gillissen A. Anti-inflammatory effects of Myrtol tandardized and other essential oils on alveolar macrophages from patients with chronic obstructive pulmonary disease. Eur J Med Res, 2009, 14(Suppl 4): 205–209.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cao L, Chen Y, Zhao Y, Zhang H, Wang S, Wang Z, et al. Effect of Myrtol standardized on mucus hypersecretion and clearance of Pseudomonas aeruginosa in a rat model of chronic obstructive pulmonary disease. Arzneimittelforschung, 2011, 61: 685–692.</mixed-citation><mixed-citation xml:lang="en">Cao L, Chen Y, Zhao Y, Zhang H, Wang S, Wang Z, et al. Effect of Myrtol standardized on mucus hypersecretion and clearance of Pseudomonas aeruginosa in a rat model of chronic obstructive pulmonary disease. Arzneimittelforschung, 2011, 61: 685–692.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ulmer WT, Schött D. Chronic obstructive bronchitis. Effect of Gelomyrtol forte in a placebo-controlled double-blind study. Fortschr Med, 1991, 109: 547–550.</mixed-citation><mixed-citation xml:lang="en">Ulmer WT, Schött D. Chronic obstructive bronchitis. Effect of Gelomyrtol forte in a placebo-controlled double-blind study. Fortschr Med, 1991, 109: 547–550.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Hua ZQ, Chang YJ. Clinical study of decoction of invigorating Qi and clearing lung combined standardized myrtol on acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Zhongguo Zhong Yao Za Zhi, 2013, 38: 440–442.</mixed-citation><mixed-citation xml:lang="en">Hua ZQ, Chang YJ. Clinical study of decoction of invigorating Qi and clearing lung combined standardized myrtol on acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Zhongguo Zhong Yao Za Zhi, 2013, 38: 440–442.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Sengespeik HC, Zimmermann T, Peiske C, de Mey C. Myrtol standardized in the treatment of acute and chronic respiratory infections in children. A multicenter post-marketing surveillance study. Arzneimittelforschung, 1998, 48: 990–994.</mixed-citation><mixed-citation xml:lang="en">Sengespeik HC, Zimmermann T, Peiske C, de Mey C. Myrtol standardized in the treatment of acute and chronic respiratory infections in children. A multicenter post-marketing surveillance study. Arzneimittelforschung, 1998, 48: 990–994.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Карпова Е.П., Тулупов Д.А., Емельянова М.П. Возможности Миртола стандартизированного в терапии острого риносинусита у детей. Вестник оториноларингологии, 2016, 81(1): 47-50.</mixed-citation><mixed-citation xml:lang="en">Карпова Е.П., Тулупов Д.А., Емельянова М.П. Возможности Миртола стандартизированного в терапии острого риносинусита у детей. Вестник оториноларингологии, 2016, 81(1): 47-50.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Кунельская Н.Л. и др. Муколитическая терапия острых и хронических риносинуситов. Медицинский совет, 2015, 3: 8-12.</mixed-citation><mixed-citation xml:lang="en">Кунельская Н.Л. и др. Муколитическая терапия острых и хронических риносинуситов. Медицинский совет, 2015, 3: 8-12.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Овчинников А.Ю., Эдже М.А., Хон Е.Н., Коростелев С.А. Острый риносинусит: основные заблуждения и возможности стандартизированной терапии. Медицинский совет, 2016, 6: 28-31.</mixed-citation><mixed-citation xml:lang="en">Овчинников А.Ю., Эдже М.А., Хон Е.Н., Коростелев С.А. Острый риносинусит: основные заблуждения и возможности стандартизированной терапии. Медицинский совет, 2016, 6: 28-31.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Зырянова К.С., Белошангин А.С., Коркмазов М.Ю. и др. Применение фитотерапевтического лекарственного препарата в лечении и профилактике острых риносинуситов у детей г. Челябинска. Педиатрический вестник Южного Урала, 2016, 1: 49-53.</mixed-citation><mixed-citation xml:lang="en">Зырянова К.С., Белошангин А.С., Коркмазов М.Ю. и др. Применение фитотерапевтического лекарственного препарата в лечении и профилактике острых риносинуситов у детей г. Челябинска. Педиатрический вестник Южного Урала, 2016, 1: 49-53.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
