medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-16-38-42medsovet-2127Research ArticleИНФЕКЦИИ В ОТОРИНОЛАРИНГОЛОГИИINFECTIONS IN OTORHINOLARYNGOLOGYМЕСТО ЦЕФАЛОСПОРИНОВ III ПОКОЛЕНИЯ В ЛЕЧЕНИИ ОСТРЫХ БАКТЕРИАЛЬНЫХ ЗАБОЛЕВАНИЙ ВЕРХНИХ ДЫХАТЕЛЬНЫХ ПУТЕЙ И УХАNICHE OF THIRD GENERATION CEPHALOSPORINS IN TREATMENT OF ACUTE BACTERIAL UPPER RESPIRATORY TRACT AND EAR INFECTIONSМальцеваГ. С.MaltsevaG. S.

Доктор медицинских наук, профессор

РязанцевС. В.RyazantsevS. B.

Доктор медицинских наук, профессор

MD, Prof.

Санкт-Петербургский научно-исследовательский институт уха, горла, носа и речи Минздрава РоссииРоссияSaint-Petersburg Research Institute of Ear, Throat, Nose and Speech of the Ministry of Health of RussiaRussian Federation2017081120170163842Copyright © Мальцева Г.С., Рязанцев С.В., 20172017Мальцева Г.С., Рязанцев С.В.Maltseva G.S., Ryazantsev S.B.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2127

Подавляющее большинство  острых респираторных  инфекций имеет вирусную природу. Основными  бактериальными патогенами, обусловливающими развитие острого синусита и острого среднего отита, являются Streptococcus  pneumoniae, Hemophilus influenza и Moraxella catarrhalis. В статье даны клинические признаки бактериальной инфекции околоносовых пазух и уха, показания к системной антибактериальной терапии. Рассмотрены вопросы выбора антибактериального препарата для лечения острого бактериального синусита и острого среднего отита, показано место цефалоспоринов III поколения в лечении указанной патологии. В статье приводится обзор данных клинических исследований эффективности и безопасности цефиксима при заболеваниях  ВДП и уха.

The vast majority of acute respiratory infections have a viral etiology. Streptococcus pneumoniae, Hemophilus influenza and Moraxella catarrhalis are the major bacterial pathogens responsible for the development of acute sinusitis and acute otitis media. The article presents clinical signs of bacterial paranasal sinuses and ear infections and indications for systemic antibacterial therapy. The issues of choice of antibacterial drugs for the treatment of acute bacterial sinusitis and acute otitis media are reviewed. The niche of third generation cephalosporins in the treatment of this pathology is also examined in this article. The article provides an overview of clinical trials of the efficacy and safety of cefixime in patients with URT and ear diseases.

острый средний отитострый бактериальный синуситStreptococcus pneumoniaeHemophilus influenzaMoraxella catarrhalisантибиотикотерапияacute otitis mediaacute bacterial sinusitisStreptococcus pneumoniaeHemophilus influenzaMoraxella catarrhalisantibiotic therapyReferencesScheid DC, Hamm RM. Acute bacterial rhinosinusitis in adults: part II. Treatment. Am Fam Physician, 2004, 70: 1697-704, 1711-2.Scheid DC, Hamm RM. Acute bacterial rhinosinusitis in adults: part II. Treatment. Am Fam Physician, 2004, 70: 1697-704, 1711-2.Gwaltney JMJr. Acute community-acquired sinusitis. Clin Infect Dis, 1996, 23: 1209-23.Gwaltney JMJr. Acute community-acquired sinusitis. Clin Infect Dis, 1996, 23: 1209-23.Dosh SA, Hickner JM, Mainous A G3d, Ebell MH. Predictors ofantibiotic prescribing for nonspecific upper respirator у infections, acute bronchitis, and acute sinusitis. An UPRNet study. Upper Peninsula Research Network. J Fam Pract, 2000, 49: 407-14.Dosh SA, Hickner JM, Mainous A G3d, Ebell MH. Predictors ofantibiotic prescribing for nonspecific upper respirator у infections, acute bronchitis, and acute sinusitis. An UPRNet study. Upper Peninsula Research Network. J Fam Pract, 2000, 49: 407-14.Ueda D, Yoto Y. The ten-day mark as a practical diagnostic approach for acute paranasal sinusitis in children. Pediat Infect Dis J, 1996, 15: 576-9.Ueda D, Yoto Y. The ten-day mark as a practical diagnostic approach for acute paranasal sinusitis in children. Pediat Infect Dis J, 1996, 15: 576-9.Diagnosis and treatment of acute bacterial rhinosinusitis. Evid Rep Technol Assess (Summ), 1999, 9: 1-5.Diagnosis and treatment of acute bacterial rhinosinusitis. Evid Rep Technol Assess (Summ), 1999, 9: 1-5.Hickner JM, Bartlett JG, Besser RE, Gonzales R, Hoffman JR, Sande MA. Principles of appropriate antibiotic use for acute rhinosinusitis in adults: background. Ann Intern Med, 2001, 134: 498-505.Hickner JM, Bartlett JG, Besser RE, Gonzales R, Hoffman JR, Sande MA. Principles of appropriate antibiotic use for acute rhinosinusitis in adults: background. Ann Intern Med, 2001, 134: 498-505.Jacobs MR, Felmingham D, Appelbaum PC, Gruneberg RN, Alexander Project Group. The Alexander Project 1998–2000: susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agents. J. Antimicrob. Chemother., 2003, 52(2): 229-246.Jacobs MR, Felmingham D, Appelbaum PC, Gruneberg RN, Alexander Project Group. The Alexander Project 1998–2000: susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agents. J. Antimicrob. Chemother., 2003, 52(2): 229-246.Brunton S. Current face of acute otitis media: Microbiology and prevalence resulting from widespread use of heptavalent pneumococcal conjugate vaccine. Clin. Ther., 2006, 28(1): 118-123.Brunton S. Current face of acute otitis media: Microbiology and prevalence resulting from widespread use of heptavalent pneumococcal conjugate vaccine. Clin. Ther., 2006, 28(1): 118-123.Block SL, Hedrick J, Harrison CJ, et al. Community-wide vaccination with the heptavalent pneumococcal conjugate significantly alters the microbiology of acute otitis media. Pediatr. Infect. Dis., 2004, 23(9): 829-833.Block SL, Hedrick J, Harrison CJ, et al. Community-wide vaccination with the heptavalent pneumococcal conjugate significantly alters the microbiology of acute otitis media. Pediatr. Infect. Dis., 2004, 23(9): 829-833.Low DE, Desrosiers M, McSherry J, Garber G, Williams JWJr, Remy H, et al. A practical guide for the diagnosis and treatment of acute sinusitis. CMAJ, 1997, 156(Suppl 6): 1-14.Low DE, Desrosiers M, McSherry J, Garber G, Williams JWJr, Remy H, et al. A practical guide for the diagnosis and treatment of acute sinusitis. CMAJ, 1997, 156(Suppl 6): 1-14.Farrell DJ, Klugman KP, Pichichero M. Increased antimicrobial resistance among nonvaccine serotypes of Streptococcus pneumoniae in the pediatric population after the introduction of 7-valent pneumococcal vaccine in the United States. Pediatr. Infect. Dis., 2007, 26(2): 123-128.Farrell DJ, Klugman KP, Pichichero M. Increased antimicrobial resistance among nonvaccine serotypes of Streptococcus pneumoniae in the pediatric population after the introduction of 7-valent pneumococcal vaccine in the United States. Pediatr. Infect. Dis., 2007, 26(2): 123-128.Jansen WTM, Verel A, Beitsma M, Verhoef J, Milatovic D. Longitudinal European surveillance study of antibiotic resistance of Haemophilus influenza. J Antimicro. Chemother., 2006, 58: 873-877.Jansen WTM, Verel A, Beitsma M, Verhoef J, Milatovic D. Longitudinal European surveillance study of antibiotic resistance of Haemophilus influenza. J Antimicro. Chemother., 2006, 58: 873-877.Hausen Th, Weidlich G, Schmitt J. Safety and efficacy of cefixime in the treatment of respiratory tract infections in Germany. Infection, 1995, 23(suppl 2): 65–69.Hausen Th, Weidlich G, Schmitt J. Safety and efficacy of cefixime in the treatment of respiratory tract infections in Germany. Infection, 1995, 23(suppl 2): 65–69.McLinn SE. Randomized, open label, multicenter trial of cefixime compared with amoxicillin for treatment of acute otitis media with effusion. Pediatr Infect Dis J, 1987, 6: 997–1001.McLinn SE. Randomized, open label, multicenter trial of cefixime compared with amoxicillin for treatment of acute otitis media with effusion. Pediatr Infect Dis J, 1987, 6: 997–1001.Owen MJ, Anwar R, Nguyen HK, Swank PR, Bannister ER, Howie VM: Efficacy of efixime in the treatment of acute otitis media in children. Am J Dis Child, 1993, 147: 81–86.Owen MJ, Anwar R, Nguyen HK, Swank PR, Bannister ER, Howie VM: Efficacy of efixime in the treatment of acute otitis media in children. Am J Dis Child, 1993, 147: 81–86.Johnson CE, Carlin SA, Super DM, Rehmus JM, Roberts DG, Christopher NC, Whitwell JK, Shurin PA. Cefixime compared with amoxicillin for treatment of acute otitis media. J Pediatr, 1991, 119: 117–122.Johnson CE, Carlin SA, Super DM, Rehmus JM, Roberts DG, Christopher NC, Whitwell JK, Shurin PA. Cefixime compared with amoxicillin for treatment of acute otitis media. J Pediatr, 1991, 119: 117–122.Rodriguez WJ, Khan W, Sait T,Chhabra OP, Bell TA, Akram S, Kohlbrenner VM: Cefixime vs. cefaclor in the treatment of acute otitis media in children: A randomized, comparative study. Pediatr Infect Dis J, 1993, 12: 70–74.Rodriguez WJ, Khan W, Sait T,Chhabra OP, Bell TA, Akram S, Kohlbrenner VM: Cefixime vs. cefaclor in the treatment of acute otitis media in children: A randomized, comparative study. Pediatr Infect Dis J, 1993, 12: 70–74.Gooch WM III, Philips A, Rhoades R, Rosenberg R, Schaten R, Starobin S: Comparison of the efficacy,safety and acceptability of cefixime and amoxicillin/clavulanate in acute otitis media. Pediatr Infect Dis J, 1997, 16(suppl 2): 21–24.Gooch WM III, Philips A, Rhoades R, Rosenberg R, Schaten R, Starobin S: Comparison of the efficacy,safety and acceptability of cefixime and amoxicillin/clavulanate in acute otitis media. Pediatr Infect Dis J, 1997, 16(suppl 2): 21–24.Яковлев С.В. Стратегия и тактика рационального применения антибиотиков. Consilium medicum, Экстравыпуск, 2013: 3-4Яковлев С.В. Стратегия и тактика рационального применения антибиотиков. Consilium medicum, Экстравыпуск, 2013: 3-4Фомина И.П., Смирнова Л.Б. Современное значение орального цефалоспорина III поколения цефиксима в терапии бактериальных инфекций. Инфекции и антимикробная терапия, 2012, 4(3): 38–40.Фомина И.П., Смирнова Л.Б. Современное значение орального цефалоспорина III поколения цефиксима в терапии бактериальных инфекций. Инфекции и антимикробная терапия, 2012, 4(3): 38–40.Brogden RN, Campoli Richards DM. Cefixime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential. Drugs, 1989, 38: 524–50.Brogden RN, Campoli Richards DM. Cefixime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential. Drugs, 1989, 38: 524–50.

The authors declare that there are no conflicts of interest present.