medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-14-6-10medsovet-2162Research ArticleТАРГЕТНАЯ ТЕРАПИЯ ОПУХОЛЕЙTarget therapy of tumorsПОВТОРНОЕ ПРИМЕНЕНИЕ ИНГИБИТОРОВ BRAF И MEK У БОЛЬНЫХ МЕТАСТАТИЧЕСКОЙ МЕЛАНОМОЙ ПОСЛЕ ПРОГРЕССИРОВАНИЯ НА ИНГИБИТОРАХ BRAF И МЕК. ОБЗОР ЛИТЕРАТУРЫ И КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕREPEATED USE OF BRAF AND MEK INHIBITORS IN METASTATIC MELANOMA PATIENTS AFTER PROFRESSION ON BRAF AND МЕК INHIBITORS. LITERATURE REVIEW AND CLINICAL OBSERVATIONСамойленкоИ. В.SamoylenkoI. V.

PhD in medicine

ЖуликовЯ. А.ZhulikovY. A.ДемидовЛ. В.DemidovL. V.

Доктор медицинских наук, профессор

MD, Prof.

Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава РоссииРоссияBlokhin National Medical Research Center of Oncology of the Ministry of Health of RussiaRussian FederationПервый Московский государственный медицинский университет им. И.М. СеченоваРоссияSechenov First Moscow State Medical UniversityRussian Federation201714112017014610Copyright © Самойленко И.В., Жуликов Я.А., Демидов Л.В., 20172017Самойленко И.В., Жуликов Я.А., Демидов Л.В.Samoylenko I.V., Zhulikov Y.A., Demidov L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2162

Появление новых эффективных лекарственных препаратов для лечения метастатической меланомы (ингибиторов BRAF/ MEK, блокаторов PD1/CTLA4) требует дополнительных исследований относительно оптимальной последовательности  их применения. Однако в значительной части случаев длительность эффекта этих лекарственных препаратов оказывается ограниченной во времени даже при их последовательном применении. В настоящем обзоре литературы рассматривается  возможность повторного назначения ингибиторов BRAF/MEK после прогрессирования на них в различных клинических ситуациях. Потенциальная польза от такого подхода проиллюстрирована двумя собственными клиническими наблюдениями.

Development of new effective drugs for therapy of metastatic melanoma (BRAF/MEK inhibitors, PD1/CTLA4 blockers) requires additional studies of the optimal sequence of their use. But in many cases the duration of the effect of these medicinal products is limited by time even in their sequential use. This literature review considers a possibility of repeated indication of BRAF/ MEK inhibitors after progression on them in various clinical settings. The potential use of such approach is illustrated by two own clinical observations.

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The authors declare that there are no conflicts of interest present.