References

medsovet

Медицинский Совет

Meditsinskiy sovet = Medical Council

2079-701X2658-5790

REMEDIUM GROUP Ltd.

10.21518/2079-701X-2017-14-88-92

medsovet-2172

Research Article

ОНКОГЕМАТОЛОГИЯ

ONCOHEMATOLOGY

ТАРГЕТНАЯ ТЕРАПИЯ БРЕНТУКСИМАБОМ ВЕДОТИНОМ ПРИ ЛЕЧЕНИИ РЕЦИДИВОВ И РЕФРАКТЕРНЫХ ФОРМ КЛАССИЧЕСКОЙ ЛИМФОМЫ ХОДЖКИНА

TARGETED THERAPY WITH BRENTUXIMAB VEDOTIN IN RELAPSED AND REFRACTORY FORMS OF CLASSICAL HODGKIN LYMPHOMA

Демина

Е. А.

Demina

E. A.

Доктор медицинских наук, профессор.

Москва

MD, Prof.

Moscow

Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава РоссииРоссияN.N. Blokhin Russian Cancer Research Center of the Ministry of Health of RussiaRussian Federation

2017

14112017

0148892

2017

Демина Е.А.

Demina E.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.med-sovet.pro/jour/article/view/2172

Современные программы терапии первой линии позволяют излечить около 80% больных классической лимфомой Ходжкина при любой стадии заболевания, однако 10–30% больных оказываются рефрактерными и нуждаются в продолжении лечения. Стандартом лечения рецидивов или резистентных форм классической лимфомы Ходжкина является химиотерапия второй линии с высокодозной консолидацией под защитой аутологичных стволовых клеток крови, но эффективность такой терапии не превышает 50% для всей группы рефрактерных больных. Появление препаратов таргетного действия, специфичных для опухолевых клеток Березовского – Рид – Штернберга, открывает новые перспективы в лечении классической лимфомы Ходжкина. В статье приводится обзор исследований по применению нового таргетного препарата брентуксимаба ведотина при лечении рецидивов и рефрактерных форм классической лимфомы Ходжкина.

Modern first-line therapy programs can cure about 80% of patients with classical Hodgkin lymphoma at any stage of the disease, but 10-30% of patients is refractory and need to continue treatment. The treatment standard for relapsed or refractory forms of classical Hodgkin lymphoma is the second-line chemotherapy with high-dose consolidation under the protection of autologous blood stem cells, but the efficacy of such therapy does not exceed 50% for the entire group of refractory patients. The release of target drugs specific for Berezovsky-Reed-Sternberg tumor cells opens up new prospects for the treatment of classical Hodgkin lymphoma. The article reviews the studies of the use of a new target drug Brentuximab Vedotin for the treatment of relapsed and refractory forms of classical Hodgkin lymphoma.

брентуксимаб ведотинклассическая лимфома Ходжкинарецидивлечение

brentuksimab vedotinclassical Hodgkin lymphomarelapsetreatment

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The authors declare that there are no conflicts of interest present.