medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-19-139-141medsovet-2203Research ArticleКЛУБ ЭКСПЕРТОВ ESPGHANESPGHAN EXPERT CLUBОЖИРЕНИЕ И КИШЕЧНАЯ МИКРОБИОТАOBESITY AND INTESTINAL MICROBIOTAЗахароваИ. Н.ZakharovaI. N.

д.м.н., профессор, 

Москва

MD, Prof., 

Moscow

БережнаяИ. В.BerezhnayaI. V.

к.м.н.,

Москва

PhD in medicine,

Moscow

ДмитриеваЮ. А.DmitrievaY. A.

к.м.н.,

Москва

PhD in medicine,

Moscow

Российская медицинская академия непрерывного профессионального образования Минздрава РоссииРоссияRussian Medical Academy of Continuous Professional Education of the Ministry of Health of RussiaRussian Federation201715122017019139141Copyright © Захарова И.Н., Бережная И.В., Дмитриева Ю.А., 20172017Захарова И.Н., Бережная И.В., Дмитриева Ю.А.Zakharova I.N., Berezhnaya I.V., Dmitrieva Y.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2203

В настоящее время существуют убедительные данные, свидетельствующие в пользу того, что микробиота желудочно-кишечного тракта обладает иммуномодулирующим и метаболическим воздействием на организм человека, а также определяет экспрессию отдельных генов посредством эпигенетических механизмов [1–3]. Особенности состава кишечной микробиоты могут предопределять особенности метаболизма макроорганизма, предрасполагая тем самым к развитию различных заболеваний, включая воспалительные заболевания кишечника, сахарный диабет 1-го типа, рассеянный склероз, расстройства аутистического спектра, сердечно-сосудистые и онкологические заболевания, метаболический синдром и ожирение [4, 5].

Currently there is conclusive evidence testifying that the microbiota of the gastrointestinal tract has an immune modifying and metabolic effect on the human body and determines expression of separate genes by means of some epigenetic mechanisms [1–3]. The peculiarities of a composition of the intestinal microbiota can predetermine peculiarities of the macroorganism metabolism hereby predisposing to the development of various disease, including inflammatory intestinal diseases, type 1 diabetes mellitus, disseminated sclerosis, disturbances of the autistic spectrum, cardiovascular and oncologic diseases, metabolic syndrome and obesity [4, 5].

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The authors declare that there are no conflicts of interest present.