medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-19-174-180medsovet-2210Research ArticleКлинический случай/ПрактикаClinical case/PracticeВЛИЯНИЕ АНТИБАКТЕРИАЛЬНОЙ ТЕРАПИИ НА СОСТОЯНИЕ ЖЕЛУДОЧНО-КИШЕЧНОГО ТРАКТА У ДЕТЕЙTHE EFFECT OF ANTIBIOTIC THERAPY ON THE INTESTINAL MICROBIOTA IN CHILDRENЗахароваИ. Н.ZakharovaI. N.

д.м.н., профессор,

Москва

MD, Prof,

Moscow

СугянН. Г.SugyanN. G.

к.м.н.,

Москва

PhD in medicine,

Moscow

ШаммасК.ShammasK.

PhD,

Лимассол

PhD, 

Limassol

АнтониадесА.AntoniadesA.

PhD, 

Лимассол

PhD, 

Limassol

НиколауЭ.NikolauE.

Limassol

КамилариЕ.CamilariE.ТитаревС. И.TitarevC. I.

Москва

Moscow

СергеевА. А.SergeevA. A.

д.м.н., 

Москва

MD,

Moscow

МнафкиН. А.MnaphkiN. A.

Москва

Moscow

Российская медицинская академия непрерывного профессионального образования Минздрава РоссииРоссияRussian Medical Academy of Continuing Vocational Education of the Ministry of Health of RussiaRussian FederationРоссийская медицинская академия непрерывного профессионального образования Минздрава России; Детская городская поликлиника №133 Департамента здравоохранения г. МосквыРоссияRussian Medical Academy of Continuing Vocational Education of the Ministry of Health of Russia; Children’s City Outpatient Clinic No 133 of the Moscow Health DepartmentRussian FederationAVVA Pharmaceuticals Ltd,КипрAVVA Pharmaceuticals Ltd, LimassolCyprusStremble Ventures LtdКипрStremble Ventures LtdCyprusДетская городская поликлиника №133 Департамента здравоохранения г. МосквыКипрAVVA Pharmaceuticals Ltd, LimassolCyprusОбщество с ограниченной ответственностью «МК Девелопмент»РоссияMK Development LtdRussian Federation201718122017019174180Copyright © Захарова И.Н., Сугян Н.Г., Шаммас К., Антониадес А., Николау Э., Камилари Е., Титарев С.И., Сергеев А.А., Мнафки Н.А., 20172017Захарова И.Н., Сугян Н.Г., Шаммас К., Антониадес А., Николау Э., Камилари Е., Титарев С.И., Сергеев А.А., Мнафки Н.А.Zakharova I.N., Sugyan N.G., Shammas K., Antoniades A., Nikolau E., Camilari E., Titarev C.I., Sergeev A.A., Mnaphki N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2210

В настоящее время уделяется всё больше внимания проблеме изменения микробиоты кишечника, особенно у детей, под влиянием различных факторов окружающей среды. Среди них прием антибактериальных препаратов – наиболее очевидный практический случай. В статье описаны результаты открытого сравнительного исследования у детей с риносинуситами по эффективности и безопасности применения традиционного азитромицина и азитромицина с лактулозой, эквивалентного по противомикробной активности, но превосходящего по профилю безопасности – сохранению баланса микрофлоры кишечника и снижению риска возникновения антибиотик-ассоциированной диареи.

The article shows the main factors that have an effect on the intestinal microbiota. Most of the focus is on the slow recovery of Bifidobacterium population after antibiotic therapy with traditional azithromycin. The authors present the results of an open comparative study in children with rhinosinusitis to evaluate the efficacy and safety of traditional azithromycin and azithromycin with lactulose that is equivalent in antimicrobial activity, but superior in the safety profile, maintaining intestinal microflora balance and reducing the risk of antibiotic-associated diarrhea.

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The authors declare that there are no conflicts of interest present.