References

medsovet

Медицинский Совет

Meditsinskiy sovet = Medical Council

2079-701X2658-5790

REMEDIUM GROUP Ltd.

10.21518/2079-701X-2017-20-26-31

medsovet-2224

Research Article

КАРДИОЛОГИЯ

CARDIOLOGY

ЛЕЧЕНИЕ ХРОНИЧЕСКОЙ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТИ С СОХРАНЕННОЙ ФРАКЦИЕЙ ВЫБРОСА ЛЕВОГО ЖЕЛУДОЧКА У ПАЦИЕНТОВ С ГИПЕРТОНИЧЕСКОЙ БОЛЕЗНЬЮ: ПОТЕНЦИАЛЬНАЯ РОЛЬ СТАТИНОВ

TREATMENT OF CHRONIC HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION IN PATIENTS WITH HYPERTENSION DISEASE: POTENTIAL THERAPEUTIC ROLE OF STATINES

Канорский

С. Г.

Kanorsky

S. G.

доктор медицинских наук; профессор.

Краснодар.

MD, Prof.

Krasnodar.

Середа

А. Ф.

Sereda

A. F.

Краснодар.

Krasnodar.

Кубанский государственный медицинский университет Минздрава России.РоссияKuban State Medical University of the Ministry of Health of Russia.Russian Federation

2017

06012018

0202631

2018

Канорский С.Г., Середа А.Ф.

Kanorsky S.G., Sereda A.F.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.med-sovet.pro/jour/article/view/2224

В проспективном рандомизированном исследовании участвовали 167 больных с хронической сердечной недостаточностью (ХСН) II/III функционального класса и сохраненной фракцией выброса левого желудочка (ФВ ЛЖ) на фоне гипертонической болезни III стадии. В дополнение к антигипертензивной терапии периндоприлом и верапамилом SR (n = 85) или амлодипином (n = 82) назначался аторвастатин, который регулярно принимали 50,6 и 48,8% пациентов соответственно. Через 12 мес. при каждом варианте лечения происходило улучшение клинического состояния и качества жизни больных, увеличивалось расстояние, пройденное в тесте с 6-минутной ходьбой. У пациентов, получавших аторвастатин, существенно снижался уровень N-концевого предшественника мозгового натрийуретического пептида, отмечалась тенденция к улучшению показателей диастолической функции ЛЖ. Добавление аторвастатина к лечению ХСН с сохраненной ФВ ЛЖ целесообразно в связи с потенциальной возможностью улучшения прогноза больных.

The prospective randomized trial included 167 patients with functional class II-III of chronic heart failure (CHF) and a preserved left ventricular ejection fraction (LVEF) affected by hypertensive disease of stage III. In addition to antihypertensive therapy with perindopril and verapamil SR (n = 85) or amlodipine (n = 82), atorvastatin was prescribed, which was regularly taken by 50.6% and 48.8% of patients, respectively. After 12 months, patients in each treatment arm showed improvement in the clinical condition and quality of life, an increase in 6MWD (6-minute walk distance). The patients receiving atorvastatin demonstrated a significant reduction in the N-terminal prohormone of brain natriuretic peptide (NT-proBNP or BNPT) level, and a tendency to improve a diastolic LV function. Adding atorvastatin to the therapy of CHF with preserved LVEF may reasonably improve the prognosis of patients.

сердечная недостаточностьсохраненная фракция выбросааторвастатинверапамиламлодипинлевый желудочекдиастолическая функция

heart failurepreserved ejection fractionatorvastatinverapamilamlodipineleft ventriclediastolic function

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The authors declare that there are no conflicts of interest present.