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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2015-8-36-39</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-224</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОНКОЛОГИЯ И ОНКОГЕМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ONCOLOGY AND ONCOHEMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Септические маски онкологических заболеваний у детей</article-title><trans-title-group xml:lang="en"><trans-title>Cancer presenting as a septic disease in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Делягин</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Delyagin</surname><given-names>V. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Качанов</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kachanov</surname><given-names>D. Y.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Уразбагамбетов</surname><given-names>А. .</given-names></name><name name-style="western" xml:lang="en"><surname>Urazbagambetov</surname><given-names>A. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солопова</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Solopova</surname><given-names>G. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терещенко</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tereschenko</surname><given-names>G. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachyov, Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2015</year></pub-date><volume>0</volume><issue>8</issue><fpage>36</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Делягин В.М., Качанов Д.Ю., Уразбагамбетов А..., Солопова Г.Г., Терещенко Г.В., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Делягин В.М., Качанов Д.Ю., Уразбагамбетов А..., Солопова Г.Г., Терещенко Г.В.</copyright-holder><copyright-holder xml:lang="en">Delyagin V.M., Kachanov D.Y., Urazbagambetov A..., Solopova G.G., Tereschenko G.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/224">https://www.med-sovet.pro/jour/article/view/224</self-uri><abstract><p>Показатель заболеваемости детей злокачественными лейкозами в различных регионах РФ колеблется от 1,9 до 4,1 на 100 000 детей в возрасте от 0 до 14 лет. При среднегодовом показателе заболеваемости детей ниже российского (3,03) и европейского (4,0) стандартов можно говорить о недоучете случаев лейкозов и других онкологических и онкогематологических заболеваний. Клинико-лабораторные и инструментальные проявления злокачественных заболеваний могут быть схожими с другими состояниями. Необходимо учитывать, что самыми частыми заболеваниями детского возраста являются инфекции. Сочетание лихорадки с болями в костях, необъяснимой гепато- и/или спленомегалией, лим-фаденопатией, изменением клеточного состава крови, повышением концентрации ЛДГ должно служить поводом для исключения злокачественного заболевания.</p></abstract><trans-abstract xml:lang="en"><p>The incidence of leukemia in children in various regions of the Russian Federation ranges from 1.9 to 4.1 per 100 000 of children aged 0 to 14 years. If the average annual morbidity of children is below the Russian (3.03) or European (4.0) standard, it is possible that some cases of leukemia and other oncological and oncohematological diseases are not reported. Clinical-laboratory and instrumental manifestations of malignant diseases can be similar to other conditions. It should be borne in mind that the most frequent childhood diseases are infections. Fever combined with bone pain, unexplained hepato- and/or splenomegaly, lymphadenopathy, changes in the cellular composition of blood and increased LDH should be the reasons to exclude malignancy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>злокачественные заболевания</kwd><kwd>ложноотрицательный диагноз</kwd><kwd>инфекции</kwd><kwd>children</kwd><kwd>malignant diseases</kwd><kwd>false-negative diagnosis</kwd><kwd>infections</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Заболеваемость населения по основным классам болезней по субъектам Российской Федерации в 2010 г.</mixed-citation><mixed-citation xml:lang="en">Заболеваемость населения по основным классам болезней по субъектам Российской Федерации в 2010 г.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Будаева Д.Д. Медико-статистический мониторинг лейкозов у детей в республике Бурятия и регионах Российской Федерации. Автореферат дисс. к.м.н., Москва, 1999: 25.</mixed-citation><mixed-citation xml:lang="en">Будаева Д.Д. Медико-статистический мониторинг лейкозов у детей в республике Бурятия и регионах Российской Федерации. Автореферат дисс. к.м.н., Москва, 1999: 25.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Халтурина И.Л. Острые лейкозы у детей Астраханской области: частотные характеристики, качество диагностики и результаты лечения. Автореферат дисс. к.м.н., Москва, 2007: 24.</mixed-citation><mixed-citation xml:lang="en">Халтурина И.Л. Острые лейкозы у детей Астраханской области: частотные характеристики, качество диагностики и результаты лечения. Автореферат дисс. к.м.н., Москва, 2007: 24.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Крылова В.В. Медико-статистические характеристики лейкозов и лимфом у детей Брянской области в период 1994-2007 гг. Автореферат дисс. к.м.н., Москва, 2011: 34.</mixed-citation><mixed-citation xml:lang="en">Крылова В.В. Медико-статистические характеристики лейкозов и лимфом у детей Брянской области в период 1994-2007 гг. Автореферат дисс. к.м.н., Москва, 2011: 34.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Forgie S, Robinson J. Pediatric malignancies presenting as a possible infectious disease. BMC Infectious Diseases,2007, 7(44) doi: 10.1186/1471-2334-7-44.</mixed-citation><mixed-citation xml:lang="en">Forgie S, Robinson J. Pediatric malignancies presenting as a possible infectious disease. BMC Infectious Diseases,2007, 7(44) doi: 10.1186/1471-2334-7-44.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Wetzler M. Acute Leuke mia in Adults. In: Conn's Current Therapy. Hematology, 2015, 12: 817-909.</mixed-citation><mixed-citation xml:lang="en">Wetzler M. Acute Leuke mia in Adults. In: Conn's Current Therapy. Hematology, 2015, 12: 817-909.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bodey G, Buckley M, Sathe Y et al. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann. Intern. Med, 1966, 64: 328-340.</mixed-citation><mixed-citation xml:lang="en">Bodey G, Buckley M, Sathe Y et al. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann. Intern. Med, 1966, 64: 328-340.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Pilar ski L, Andrews E, Mant M et al. Humoral immune deficiency in multiple myeloma patients due to compromised B-cell function. J. Clin. Immunol,1986,6: 491-501.</mixed-citation><mixed-citation xml:lang="en">Pilar ski L, Andrews E, Mant M et al. Humoral immune deficiency in multiple myeloma patients due to compromised B-cell function. J. Clin. Immunol,1986,6: 491-501.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Siegenthaler W, Aeschliman A (Hrsg.) Differentialdiagnose innere Krankheiten. Thieme Verlag, Berl in, 2005: 1133.</mixed-citation><mixed-citation xml:lang="en">Siegenthaler W, Aeschliman A (Hrsg.) Differentialdiagnose innere Krankheiten. Thieme Verlag, Berl in, 2005: 1133.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
