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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2017-20-166-170</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-2249</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДЕРМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DERMATOLOGY</subject></subj-group></article-categories><title-group><article-title>ТЕРАПИЯ АЛЛЕРГОДЕРМАТОЗОВ С ПРИМЕНЕНИЕМ КОМБИНИРОВАННОГО НАРУЖНОГО СРЕДСТВА</article-title><trans-title-group xml:lang="en"><trans-title>TOPICAL MEDICINES IN THE TREATMENT OF ALLERGODERMATHOSIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хамаганова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Khamaganova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор.</p><p>Москва.</p></bio><bio xml:lang="en"><p> MD, Prof.</p><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет им. Н.И. Пирогова.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University.</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>07</day><month>01</month><year>2018</year></pub-date><volume>0</volume><issue>20</issue><fpage>166</fpage><lpage>170</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хамаганова И.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Хамаганова И.В.</copyright-holder><copyright-holder xml:lang="en">Khamaganova I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/2249">https://www.med-sovet.pro/jour/article/view/2249</self-uri><abstract><p>При аллергодерматозах нарушение кожного барьера, увеличение трансэпидермальной потери воды, изменение рН ведут к снижению защитных механизмов кожи, вследствие чего отмечается повышенная восприимчивость кожи к инфекциям. Развитие осложнений предопределило интерес к совершенствованию наружной терапии. В статье представлен краткий обзор литературных данных о высокой терапевтической активности и хорошей переносимости топического средства Тридерм. При сравнении с оригинальным препаратом у дженериков выявлены отличия в структурно-механических свойствах, что влияет на показатели биодоступности. Собственное сравнение терапевтической эффективности и переносимости показало, что Тридерм более эффективен, а по переносимости сопоставим с Акридермом ГК.</p></abstract><trans-abstract xml:lang="en"><p>Skin lesions, increased transepidermal water loss, changes in pH in patients with allergodermathosis lead to a decrease in the protective mechanisms of the skin that makes individuals more susceptible to infections. The development of complications predefined the interest in improving topical therapy. The article presents a brief review of the literature data on high therapeutic activity and good tolerability of the topical drug Triderm. When compared with the original drug, the generics revealed differences in the structural and mechanical properties, which affects bioavailability. A comparison of therapeutic efficacy and tolerability has shown that Triderm is more effective, and comparable to Akriderm GK in terms of tolerability.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>Тридерм</kwd><kwd>лекарственные формы</kwd><kwd>Акридерм ГК</kwd><kwd>эффективность и переносимость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Triderm</kwd><kwd>pharmaceutical forms</kwd><kwd>Akriderm GK</kwd><kwd>efficacy and tolerability</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nutten S. Atopic dermatitis: global epidemiology and risk factors. 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