medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2017-20-177-181medsovet-2251Research ArticleУРОЛОГИЯUROLOGYАНТИОКСИДАНТНАЯ ТЕРАПИЯ – КЛЮЧ К ЛЕЧЕНИЮ ИДИОПАТИЧЕСКОГО МУЖСКОГО БЕСПЛОДИЯANTIOXIDANT THERAPY IS THE KEY TO THE TREATMENT OF IDIOPATHIC MALE INFERTILITYОвчинниковР. И.OvchinnikovR. I.

кандидат медицинских наук.

Москва. 

PhD in medicine.

Moscow.

ПоповаА. Ю.PopovaA. Yu.

кандидат медицинских наук.

Москва. 

PhD in medicine.

Moscow.

ГамидовС. И.GamidovS. I.

доктор медицинских наук, профессор.

Москва.

MD, Prof.

Moscow.

КвасовА. В.KvasovA. V.

Москва.

Moscow.

Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова Минздрава России.РоссияKulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of Russia.Russian Federation201707012018020177181Copyright © Овчинников Р.И., Попова А.Ю., Гамидов С.И., Квасов А.В., 20182018Овчинников Р.И., Попова А.Ю., Гамидов С.И., Квасов А.В.Ovchinnikov R.I., Popova A.Y., Gamidov S.I., Kvasov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2251

Идиопатическое бесплодие (ИБ) составляет до 30% мужского бесплодия. Антиоксиданты эмпирически использовались при лечении ИБ на основе их способности улучшать репродуктивную функцию, угнетенную оксидативным стрессом (ОС), часто встречающимся у этих пациентов. Основная цель обзорной статьи состояла в том, чтобы сообщить об обоснованности имеющихся данных, подтверждающих использование антиоксидантов. Было показано, что антиоксиданты, такие как глутатион, витамины Е и С, карнитины, коэнзим-Q10, N-ацетилцистеин, селен, цинк, фолиевая кислота и ликопин, уменьшают повреждение спермы, вызванное ОС. Хотя строгие научные данные в форме двойных слепых плацебо-контролируемых клинических исследований ограниченны, последние систематические обзоры и метаанализы сообщили о положительном эффекте антиоксидантов на параметры спермы и показатели рождаемости. Для подтверждения эффективности и безопасности антиоксидантной терапии в лечении ИБ требуются дополнительные рандомизированные контролируемые исследования с целью определения эффективной дозировки, сроков лечения, необходимых для улучшения параметров спермы, наступления беременности и рождения здорового ребенка.

Idiopathic infertility (II) accounts for up to 30% of male infertility. Antioxidants were empirically used in the treatment of II based on their ability to improve reproductive function suppressed by oxidative stress (OS), which was often found in these patients. The review article was aimed to report the validity of available data confirming the use of antioxidants. Antioxidants such as glutathione, vitamins E and C, carnitines, coenzyme Q10, N-acetylcysteine, selenium, zinc, folic acid and lycopene have been shown to reduce sperm damage caused by OS. Although rigorous scientific evidence in the form of double-blind, placebo-controlled clinical trial is limited, recent systematic reviews and meta-analyses showed a positive effect of antioxidants on sperm parameters and fertility rates. There is, however, a need for further investigation with randomised controlled studies to confirm the efficacy and safety of antioxidant therapy in the medical treatment of idiopathic male infertility as well as the need to determine the effective dose of each compound to improve semen parameters, fertilisation rates and healthy pregnancy outcomes.

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The authors declare that there are no conflicts of interest present.