The article is devoted to the study and analysis of the pharmacotherapeutic competence of the graduates of the medical university on the threshold of the independent medical activity in the primary link of public health. 169 students of the 6th year of the Medical Department of Yevdokimov MGMSU responded in writing to 8 tasks which proposed to name the optimal medicinal products (MP) in a number of standard situations of outpatient practice. The mean median of the selection evaluation was 11 points out of 16 impliable meanings. Each respondent indicated his average academic performance and assessed his/her own confidence in reasonable command of pharmacotherapy – the mean median for these indicators was 3 out of 5 and 6 out of 10 points, respectively. All 3 studied parameters showed a very weak positive relationship between themselves in ρ range from 0.19 to 0.24 for p <0.05. In the separate analysis of these indicators in the subgroups of students with high and average academic performance, no relationship between performance, assessment of drug choice and self-assessment of pharmacotherapeutic competence has been identified. The average assessment of the choice of drugs between these subgroups did not differ either. The data given indicate that the best average academic performance does not guarantee higher competence of respondents in the choice of medicines. The authors recommend purposeful pharmacotherapeutic preparation of students on the graduate course, taking into account the specificity of the forthcoming medical activity.