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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2015-8-44-46</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-226</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОНКОЛОГИЯ И ОНКОГЕМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ONCOLOGY AND ONCOHEMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Роль простатспецифического антигена в прогнозе гормоночувствительного рака предстательной железы</article-title><trans-title-group xml:lang="en"><trans-title>The role of prostate-specific antigen in the prediction of hormone-sensitive prostate cancer</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Грицкевич</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gritskevich</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мишугин</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mishugin</surname><given-names>S. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Теплов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Teplov</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Медведев</surname><given-names>В. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Medvedev</surname><given-names>V. L.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Русаков</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Rusakov</surname><given-names>I. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт хирургии им. А.В. Вишневского, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Senior Researcher, Vishnevsky Institute of Surgery, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Городская клиническая больница №57, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Hospital №57, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Институт хирургии им. А.В. Вишневского, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Vishnevsky Institute of Surgery, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Научно-исследовательский институт - Краевая клиническая больница №1 им. проф. С.В. Очаповского, Краснодар</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute Regional Clinical Hospital №1 named after Prof. S.V. Ochapovskiy, Krasnodar</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Городская клиническая больница №57, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Hospital No. 57, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2015</year></pub-date><volume>0</volume><issue>8</issue><fpage>44</fpage><lpage>46</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Грицкевич А.А., Мишугин С.В., Теплов А.А., Медведев В.Л., Русаков И.Г., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Грицкевич А.А., Мишугин С.В., Теплов А.А., Медведев В.Л., Русаков И.Г.</copyright-holder><copyright-holder xml:lang="en">Gritskevich A.A., Mishugin S.V., Teplov A.A., Medvedev V.L., Rusakov I.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/226">https://www.med-sovet.pro/jour/article/view/226</self-uri><abstract><p>Проведено ретроспективное исследование 429 больных с гистологически подтвержденным диагнозом РПЖ, получавших различные методы лечения в период 1995-2014 гг. Общая продолжительность жизни с исходным уровнем ПСА менее 30 нг/мл составляла в среднем 50,5 мес., при более высоких показателях ПСА продолжительность жизни уменьшалась до 28 мес. вне зависимости от проводимого лечения. Причиной смерти 150 (35%) пациентов с ПСА до 30 нг/мл являлась неонкологическая природа заболевания. Даже при исходном ПСА более 30 нг/мл 39 больных (9,1%) погибло от сопутствующей патологии. ПСА более 30 нг/мл является неблагоприятным прогностическим признаком, что требует более агрессивного подхода к лечению данной группы пациентов. Показатель Глисона более 7 баллов, помимо ухудшения прогноза продолжительности жизни, также весьма весомо ухудшает качество жизни. Определение уровня ПСА по-прежнему играет ключевую роль в раннем выявлении РПЖ.</p></abstract><trans-abstract xml:lang="en"><p>429 patients with histologically confirmed prostate cancer undergoing various treatment from 1995 till 2014 were studied retrospectively. Overall survival with the baseline PSA less than 30 ng/ml averaged 50.5 months; with higher rates of PSA, the lifespan was reduced to 28 months regardless of treatment. The cause of death of 150 (35%) patients with PSA below 30ng/ml was not an oncological disease. Even with the initial PSA more than 30 ng/ml, 39 patients (9.1%) died from comorbidities. PSA above 30 ng/ml is a poor prognostic factor requiring a more aggressive approach to the treatment of these patients. Gleason score above 7 points is associated with a worse life expectancy forecast as well as a considerable decrease in the quality of life. PSA level determination continues to play a key role in the early detection of prostate cancer.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак предстательной железы</kwd><kwd>индекс Глисона</kwd><kwd>простатспецифический антиген</kwd><kwd>prostate cancer</kwd><kwd>Gleason score</kwd><kwd>prostate-specific antigen</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Каприн А.Д., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2013 году. М., 2015: 9-15.</mixed-citation><mixed-citation xml:lang="en">Каприн А.Д., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2013 году. М., 2015: 9-15.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Чехонин, В.П. 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