medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2018-1-6-12medsovet-2261Research ArticleКОГНИТИВНЫЕ НАРУШЕНИЯ И ДЕМЕНЦИЯCOGNITIVE IMPAIRMENT AND DEMENTIAВедение пациентов с болезнью АльцгеймераMANAGEMENT OF PATIENTS WITH ALZHEIMER’S DISEASEПарфеновВ. А.ParfenovV. A.

д.м.н., профессор

MD, Prof.

КабаеваА. Р.KabaevaA. R.Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский университет)РоссияSechenov First Moscow State Medical University of the Ministry of Health of RussiaRussian Federation20180502201801612Copyright © Парфенов В.А., Кабаева А.Р., 20182018Парфенов В.А., Кабаева А.Р.Parfenov V.A., Kabaeva A.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/2261

Представлен обзор литературных данных по ведению пациентов с болезнью Альцгеймера (БА). Психосоциальные и поведенческие направления составляют основу ведения пациента с БА и должны использоваться как можно раньше и оставаться на протяжении всей оставшейся жизни. Ингибиторы центральной ацетилхолинэстеразы (донепезил, галантамин, ривастигмин) и мемантин способны улучшить когнитивные функции. Профилактика инсульта расценивается как наиболее эффективное средство снижения риска развития БА и прогрессирования ее симптомов. Постепенная нормализация артериального давления у пациентов с артериальной гипертензией уменьшает риск возникновения различных типов деменций, включая БА. Употребление в большом количестве свежих фруктов или овощей, средиземноморская диета, регулярные физические нагрузки и умственная активность сочетаются со снижением частоты развития БА. Обсуждаются особенности ведения пациентов с БА в нашей стране, применение Церебролизина и методы вакцинации.

 

The article presents a literature review on the management of patients with Alzheimer’s disease (AD). Psychosocial and behavioural trends form the core of the management of a patient with AD and should be used as early as possible and remain in use for the rest of her/his life. Inhibitors of central acetylcholinesterase (donepizil, galantamine, rivastigmine) and memantine are able to improve cognitive functions. Stroke prevention has been considered the mainstay in reducing the risk of developing AD and the progression of its symptoms. Gradual normalization of arterial pressure in patients with hypertension reduces the risk of various types of dementia, including asthma. The use of a large number of fresh fruits or vegetables, the Mediterranean diet, regular exercise and mental activity are associated with a decrease in the incidence of AD. The article discusses the management of patients with AD in our country, the use of Cerebrolysin and methods of vaccination.

 

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The authors declare that there are no conflicts of interest present.